Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. &amp; Schltdl.) Wawra

Carvalho, Almir Ribeiro de; Ferreira, Rafaela Oliveira; Passos, Michel de Souza; Boeno, Samyra Imad da Silva; Virgens, Lorena de Lima Glória das; Ventura, Thatiana Lopes Biá; Calixto, Sanderson Dias; Lassounskaia, Elena; Carvalho, Mário Geraldo de; Braz-Filho, Raimundo; Vieira, Ivo José Curcino

doi:10.3390/molecules24061026

Cited by 18 publications

(11 citation statements)

References 47 publications

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“…Strictosidine - type indole alkaloid glycosides : The condensation of tryptophan and iridoid glycoside secologanin yields strictosidine, the precursor of 5α-carboxystrictosidine (Log D-3.1 at pH 7.4; molecular mass = 574.5 g/mol), which inhibited the growth of M. tuberculosis (H37Rv) with the MIC value of 26.3 µg/mL [ 72 ].…”

Section: Indole Alkaloidsmentioning

confidence: 99%

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

et al. 2022

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The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 Å2, and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2′-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC ≤ 1 µg/mL and are candidates for the development of lead molecules.

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Section: Indole Alkaloidsmentioning

confidence: 99%

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

et al. 2022

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“…and Schltdl.) Wawra, 13 exhibited in vitro antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv with a reported MIC value of 26.3 µg/mL [54].…”

Section: β-Carboline Alkaloidsmentioning

confidence: 99%

“…Hydroxycinnamic acids (54)(55)(56)(57)(58) are described in Table 2. It should be noted that chlorogenic acid ( 58) is structurally related to caffeic acid (55).…”

Section: Hydroxycinnamic Acidsmentioning

confidence: 99%

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Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Blanck¹,

Huebner²,

Rolls³

et al. 2022

AppliedChem

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Cat’s claw (Uncaria tomentosa (Willd. ex Schults) DC.), a plant that is exceptionally rich in phytochemicals, has been used for centuries by the indigenous people of South and Central America as a therapeutic and is currently widely exported for medicinal purposes. Extracts and individual components have shown considerable potential as antibacterials in the literature. The purpose of this review is twofold: first, to provide a substantiated, comprehensive collection of the known chemical constituents of U. tomentosa, including their detailed structures; second, to identify those components that offer some promise as antibacterials based on the research to date. Bacterial resistance to currently available antibiotics continues to increase and is widely recognized as an impending, potentially catastrophic, problem. There is research to suggest that U. tomentosa components may have antibacterial potential individually or synergistically with established antibiotics against microbes, including Borrelia burgdorferi, the causative agent of Lyme disease. It is our intention that this review will provide a valuable resource to investigators in search of new antimicrobials to meet the daunting challenge of antibiotic resistance.

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“…Espécies de Annona são conhecidas pela biossíntese de alcaloides (Quílez et al, 2018). Várias atividades farmacológicas são atribuídas aos alcaloides, como antimicrobiana e anti-inflamatória (Carvalho Junior et al, 2019).…”

Section: Classes De Metabólitosunclassified

Prospecção fitoquímica, teor de fenóis totais e atividade antiradicalar de extrato e frações de folhas de Annona sylvatica (Annonaceae)

Trindade

Carvalho

Ferreira

2021

RSD

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O consumo de plantas medicinais tem apresentado um crescimento considerável em diversos países. Annona sylvatica, conhecida vulgarmente como araticum-do-mato, é uma frutífera empregada na medicina popular para baixar a pressão arterial. O objetivo deste trabalho foi investigar o perfil fitoquímico e avaliar a atividade antioxidante de extrato e frações de folhas de A. sylvatica. O extrato em etanol foi obtido por maceração e submetido à partição líquido-líquido para obtenção das frações em hexano, clorofórmio e acetato de etila. As principais classes de metabólitos secundários foram detectadas por prospecção fitoquímica, o teor de fenóis totais (FT) e a atividade antioxidante foram quantificados pelos testes de Folin-Dennis e ensaio da atividade sequestradora do radical DPPH, respectivamente. Através do coeficiente de Pearson, os teores de fenóis totais foram correlacionados com os valores de CE50 observados no ensaio do DPPH. A prospecção fitoquímica detectou a presença de flavonoides, saponinas, alcaloides e triterpenos/esteroides. A fração AcOET apresentou o maior teor de fenóis totais e maior atividade no ensaio do DPPH, com os valores de 84,0±4,4 mg EAG. g-1 e CE50 9,28 µg. mL-1, respectivamente. Observou-se uma forte correlação negativa entre o teor de FT e os valores de CE50, sugerindo que parte da atividade antioxidante observada está relacionada ao teor de FT. Os resultados sugerem que a araticum-do-mato é uma importante fonte de antioxidantes naturais.

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Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

Cited by 18 publications

References 47 publications

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Prospecção fitoquímica, teor de fenóis totais e atividade antiradicalar de extrato e frações de folhas de Annona sylvatica (Annonaceae)

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