Antimycobacterial Efficacy of <i>Andrographis paniculata</i> Leaf Extracts Under Intracellular and Hypoxic Conditions

Bhatter, Purva; Gupta, P.; Daswani, Poonam; Tetali, P.; Birdi, Tannaz

doi:10.1177/2156587214553303

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…Plant-derived antimicrobial compounds belong to an exceptionally wide diversity of classes, including terpenoids (Bhalodia et al, 2011), lignans (Teponno et al, 2016), alkaloids and peptides (Bhatter et al, 2016), phenolic compounds (Heleno et al, 2015) and coumarins (Bhatter et al, 2015, 2016). All of the aforementioned compounds are regarded as secondary metabolism products in plants, not strictly required for their survival, but usually conferring a positive effect for its use as medicinal purposes (Harborne, 1997; Kroymann, 2011).…”

Section: Introductionmentioning

confidence: 99%

Commiphora leptophloeos Phytochemical and Antimicrobial Characterization

Pereira

Jandú

et al. 2017

Front. Microbiol.

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Commiphora leptophloeos is a plant specie usually known for its medicinal purposes in local communities in Northeast Brazil. In order to evaluate its therapeutic potential, we aimed to determine the phytochemical and antimicrobial properties of C. leptophloeos extracts. Thin Layer Chromatography (TLC) was able to detect the presence of phenolic compounds, flavonoids and reducing sugars. Three phenolic compounds were identified by HPLC and described as Gallic, Chlorogenic and Protocatechuic acids. On the other hand, H1NMR analysis revealed the presence of hinokinin, a bioactive lignan further characterized in the present work. The minimum inhibitory concentration (MIC) values for hinokinin ranged from 0.0485 to 3.125 mg/mL in different S. aureus clinical isolates and showed a bactericidal activity against MRSA isolated from blood (MMC 0.40 mg/mL) and postoperative secretion (MMC = 3.125 mg/mL). C. leptophloeos extracts also showed antimicrobial activity against Mycobacterium species such as M. smegmatis (MIC = 12.5 mg/mL) and M. tuberculosis (MIC = 52 mg/mL). Additionally, we determined the toxicity of C. leptophloeos by in vitro HC50 tests with hemolytic activity detected of 313 ± 0.5 μg/mL. Our results showed that C. leptophloeos possesses inhibitory properties against MRSA as well as several other clinically important microorganisms. Furthermore, the present work is the first report of the presence of hinokinin in Commiphora genus.

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Section: Introductionmentioning

confidence: 99%

Commiphora leptophloeos Phytochemical and Antimicrobial Characterization

Pereira

Jandú

et al. 2017

Front. Microbiol.

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“…The inhibition increase with double stimuli or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts (Bhatter et al, 2015). The methanolic leaves extract of Andrographis paniculata showed a potential destructive effect on Staphiloccocus aureus where total cell killing was attained in 24 h based on the time-kill assay.…”

Section: Thin Layer Chromatogphic Analysis (Tlc)mentioning

confidence: 99%

Identification of Medicinal Organic Components of Andrographis paniculata Leaf Extracts

Onojake

Ngochindo

Okocha

2020

Pak. j. sci. ind. res. Ser. A: phys. sci.

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Active metabolites of methanol, ethanol, ethyl acetate and aqueous extracts of the leaves of Andrographis paniculata were identified using thin layer chromatography and gas chromatography-mass spectrometry (GC-MS). Results from this study identified some of active metabolites as andrographolide, 14-deoxyandrographolide, neoandrographolide, 14-deoxy-11,12-di-dehydroandrographolide, andrographanin, isoandrographolide, 14-acetylandrographolide, 19-0-andrographolide, beta-sitosterol and 14-deoxy-14,15- dihydroandrographolide. Ethanol was a more effective solvent for the extraction as most of the phytochemicals were identified in this extract. Research had shown that extracts from the leaves of the plant possess a lot of therapeutic properties such as anti-microbial, anti-inflammatory, anti-diabetic, immune modulatory and antimalarial activities which are of immense benefit to man.

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“…Among the extraction methods, ethanol, hexane, and methanol were found to be the top three frequently used [7,190] Angiopteris evecta Marattiaceae Leaf 80% methanol extract against M. tuberculosis H37Rv ATCC 25618 with an MIC of 400 μg/ml [191] Apodytes dimidiata Icacinaceae Leaf Hexane extractions against the field strain of MDR-TB and against the M. tuberculosis H37Rv with MIC of 0.47 and 0.31 mg/ml, respectively [192] Artemisia ludoviciana Asteraceae Bark, leaf Hexane extracts against MDR-TB clinical isolates with MIC of 25-100 μg/ml [58,193] Artemisia nilagirica Asteraceae Leaf Ethanol extracts against M. smegmatis with IC50 c of 300 μg/ml [194] Beilschmiedia obscura Lauraceae Root Ethyl acetate extracts against M. tuberculosis H37Rv with MIC of 31.25 μg/ml by MABA b [195] Bidens odorata Asteraceae Aerial parts Hexane, dichloromethane, ethyl acetate, and ethanolic extracts against M. tuberculosis H37Rv (ATCC 27294) with MIC of 100, 12.5, 12.5, and 12.5 μg/ml [196] Bridelia micrantha Euphorbiaceae Bark Acetone extracts against M. tuberculosis H37Ra with MIC of 25 μg/ml [197] Calluna vulgaris Ericaceae Aerial parts…”

Section: Plants Showing Anti-tb Effect In Form Of Crude Extractsmentioning

confidence: 99%

Traditional Medicinal Plants as a Source of Antituberculosis Drugs: A System Review

Liang

Kong

et al. 2021

BioMed Research International

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Medicinal plants are the chief components in the different oriental formulations in different traditional medical systems worldwide. As a thriving source of medicine, the medicinal plants with antituberculosis (TB) properties inspire the pharmacists to develop new drugs based on their active components or semimetabolites. In the present review, the anti-TB medicinal plants were screened from the scientific literatures, based on the botanical classification and the anti-TB activity. The obtained anti-TB medicinal plants were categorized into three different categories, viz., 159 plants critically examined with a total 335 isolated compounds, 131 plants with their crude extracts showing anti-TB activity, and 27 plants in literature with the prescribed formula by the traditional healers. Our systemic analysis on the medicinal plants can assist the discovery of novel and more efficacious anti-TB drugs.

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Antimycobacterial Efficacy of Andrographis paniculata Leaf Extracts Under Intracellular and Hypoxic Conditions

Cited by 6 publications

References 16 publications

Commiphora leptophloeos Phytochemical and Antimicrobial Characterization

Commiphora leptophloeos Phytochemical and Antimicrobial Characterization

Identification of Medicinal Organic Components of Andrographis paniculata Leaf Extracts

Traditional Medicinal Plants as a Source of Antituberculosis Drugs: A System Review

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