Antimycobacterial natural products

Copp, Brent R.

doi:10.1039/b212154a

Cited by 186 publications

(103 citation statements)

References 229 publications

(305 reference statements)

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Terpene quinones, including puupehenone metabolites, have been extensively studied for their antimicrobial and cytotoxic properties (32,(48)(49)(50)(51)(52). Nonetheless, this is the first report demonstrating that they selectively inhibit dormant drug-tolerant M. tuberculosis.…”

Section: Discussionmentioning

confidence: 95%

Selective Killing of Dormant Mycobacterium tuberculosis by Marine Natural Products

Felix

Gupta

Geden

et al. 2017

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The dormant phenotype acquired by Mycobacterium tuberculosis during infection poses a major challenge in disease treatment, since these bacilli show tolerance to front-line drugs. Therefore, it is imperative to find novel compounds that effectively kill dormant bacteria. By screening 4,400 marine natural product samples against dual-fluorescent M. tuberculosis under both replicating and nonreplicating conditions, we have identified compounds that are selectively active against dormant M. tuberculosis. This validates our strategy of screening all compounds in both assays as opposed to using the dormancy model as a secondary screen. Bioassayguided deconvolution enabled the identification of unique pharmacophores active in each screening model. To confirm the activity of samples against dormant M. tuberculosis, we used a luciferase reporter assay and enumerated CFU. The structures of five purified active compounds were defined by nuclear magnetic resonance (NMR) and mass spectrometry. We identified two lipid compounds with potent activity toward dormant and actively growing M. tuberculosis strains. One of these was commercially obtained and showed similar activity against M. tuberculosis in both screening models. Furthermore, puupehenone-like molecules were purified with potent and selective activity against dormant M. tuberculosis. In conclusion, we have identified and characterized antimycobacterial compounds from marine organisms with novel activity profiles which appear to target M. tuberculosis pathways that are conditionally essential for dormancy survival.

show abstract

Section: Discussionmentioning

confidence: 95%

Selective Killing of Dormant Mycobacterium tuberculosis by Marine Natural Products

Felix

Gupta

Geden

et al. 2017

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…According to Copp,20 secondary metabolites of terpenoid origin are among the most promising classes of natural products with antimycobacterial activity.…”

Section: Resultsmentioning

confidence: 99%

Triterpenes and antitubercular activity of Byrsonima crassa

Higuchi¹,

Pavan²,

Leite³

et al. 2008

Quím. Nova

View full text Add to dashboard Cite

daisy nakamura sato Instituto Adolfo Lutz de Ribeirão Preto, Rua Minas, 877, 14085-410 Ribeirão Preto -SP, Brasil Recebido em 7/12/07; aceito em 8/5/08; publicado na web em 19/9/08We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 -312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.

show abstract

“…Some recent reports have demonstrated the in vitro bioassay activity of plant-derived terpenoids against M. tuberculosis (Cantrell et al, 2001;. The literature also reports the antimycobacterial activity of many classes of natural products: such as alkanes, phenolics, acetogenic quinines, flavonoids, triterpenes, flavonones and chalcones (Copp, 2003;Pavan et al, 2009). Previous results demonstrated that indigotin alkaloid can enhance macrophage functions and therefore contribute to the host defense against pathogens and tumors (Lopes et al, 2006).…”

Section: Plant With Antimycobacterial and Immunostimulating Activitymentioning

confidence: 99%

Potential Use of I. suffruticosa in Treatment of Tuberculosis with Immune System Activation

Carli¹,

Quilles²,

Maia³

et al. 2012

Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance

View full text Add to dashboard Cite

Antimycobacterial natural products

Cited by 186 publications

References 229 publications

Selective Killing of Dormant Mycobacterium tuberculosis by Marine Natural Products

Selective Killing of Dormant Mycobacterium tuberculosis by Marine Natural Products

Triterpenes and antitubercular activity of Byrsonima crassa

Potential Use of I. suffruticosa in Treatment of Tuberculosis with Immune System Activation

Contact Info

Product

Resources

About