Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent

Muraina, Issa A.; Adaudi, A O; Mamman, Muhammed; Kazeem, Haruna M.; Picard, J.; McGaw, Lyndy Joy; Eloff, Jacobus Nicolaas

doi:10.3109/13880200903505633

Cited by 39 publications

(24 citation statements)

References 14 publications

(16 reference statements)

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“…Plant also shows anti-mycoplasmal [35] and antifungal activity. [29] Plant induce neuromuscular blocking activity and show electrophysiological effects on cardiac, smooth and skeletal muscle contraction.…”

Section: Therapeutic Usesmentioning

confidence: 99%

Ethnomedicinal, pharmaceutical and pesticidal uses ofCalotropis procera(Aiton) (Family: Asclepiadaceae)

Upadhyay¹

2014

Int J Green Pharm

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Caloropis procera is a multipurpose plant that is extensively used by traditional folk healers and local people for preparation of different drugs and ailments of choice to treat different diseases and disorders. Plant contains diverse phyto-chemicals which show various pharmaceutical and ethno-medicinal properties. Two related species are of Asclepiadaceae, Caloropis procera and Calotropis gigantea, and both possess enormous disease curing potential against various infectious agents such as bacteria, viruses, fungi, protozoans and worms; and are widely used for treatment of different diseases and physiological disorders. Active components of Calotropis procera displayed cytostatic, cytotoxic, wound healing, procogulant, analgesic, anticonvulsant, anti-arthritic, antidiabetic, hepatoprotective, anti-fertility, antipyretic, anti-coccidial, anticancer, antitumor and anti-inflammatory properties. Natural Calotropis latex in preserved and concentrated forms finds many pharmaceutical applications and may be more useful in interventional therapies, complementary and alternative medicine to cure different types of cancers. Latex can be used for preparation of various herbal drugs and drug templates which might be non-steroidal and show wider cancer suppressing efficacy in patients. Plant can become a future source of therapeutic drugs, pesticides and industrial products. It can be used for phyto-extraction of toxic chemicals and reclamation of polluted derelict lands.

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Section: Therapeutic Usesmentioning

confidence: 99%

Ethnomedicinal, pharmaceutical and pesticidal uses ofCalotropis procera(Aiton) (Family: Asclepiadaceae)

Upadhyay¹

2014

Int J Green Pharm

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“…Figure 1 depicts the various traditional uses of Vernonia amygdalina. The biologically-active compounds of Vernonia amygdalina are saponins and alkaloids [9], terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones and anthraquinone [10], edotides [11] and sesquiterpenes [4]. …”

Section: Introductionmentioning

confidence: 99%

Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid

Farombi

Owoeye

2011

IJERPH

289

188

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Recently, considerable attention has been focused on dietary and medicinal phytochemicals that inhibit, reverse or retard diseases caused by oxidative and inflammatory processes. Vernonia amygdalina is a perennial herb belonging to the Asteraceae family. Extracts of the plant have been used in various folk medicines as remedies against helminthic, protozoal and bacterial infections with scientific support for these claims. Phytochemicals such as saponins and alkaloids, terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, edotides and sesquiterpenes have been extracted and isolated from Vernonia amygdalina. These compounds elicit various biological effects including cancer chemoprevention. Garcinia kola (Guttiferae) seed, known as “bitter kola”, plays an important role in African ethnomedicine and traditional hospitality. It is used locally to treat illnesses like colds, bronchitis, bacterial and viral infections and liver diseases. A number of useful phytochemicals have been isolated from the seed and the most prominent of them is the Garcinia bioflavonoids mixture called kolaviron. It has well-defined structure and an array of biological activities including antioxidant, antidiabetic, antigenotoxic and hepatoprotective properties. The chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoids have been attributed to their abilities to scavenge free radicals, induce detoxification, inhibit stress response proteins and interfere with DNA binding activities of some transcription factors.

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“…[6] They are effective against amoebic dysentery, [7] gastrointestinal disorders, [8] and have antimicrobial and antiparasitic activities. [9,10] The biologically-active compounds of Vernonia amygdalina are saponins and alkaloids, [11] terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones and anthraquinones, [12] edotides, [13] and sesquiterpenes. [6] Vernonia amygdalina has been shown to contain appreciable quantities of ascorbic acid and carotenoids.…”

Section: Introductionmentioning

confidence: 99%

Subacute effect of Vernonia amygdalina methanolic crude leaf extract on the hematological profile in albino Wistar rats

Nubila

Ukaejiofo

et al. 2013

Niger J Exp Clin Biosci

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Background: Vernonia amygdalina is among one of the most used medicinal plants with a higher safety and effi cacy in managing a wide array of medical ailments. The objective of this study is to evaluate the subacute effects of the methanolic crude leaf extract of Vernonia amygdalina on the hematological profi le in Albino Wistar rats. Materials and Methods: Thirty Albino rats were used for the study. They were equally grouped into fi ve groups: A (control), B, C, D, and E groups. The test (B, C, D, and E) groups were gavaged with doses (10, 15, 25, and 40 mg/kg body weight, respectively) of Vernonia amygdalina leaf methanolic extract once daily, for nine days. Two milliliters of blood was collected from two animals each from each group on days three, six, and nine, for the determination of the hematological profi le using a hematology analyzer. Results: Mean cell hemoglobin mean value showed a statistically signifi cant increase (P < 0.05) in group C (15 mg/kg body weight). Similarly, a statistically signifi cant increase (P < 0.01) was recorded in group E (40 mg/kg body weight) on day three, when compared with the control group A (untreated). However, only the mean value of the platelet count revealed a statistically signifi cant decrease (P < 0.05) in group D (25 mg/kg body weight) on day six, when compared with the control. Conclusion: The subacute administration of Vernonia amygdalina methanolic crude leaf extract does not possess hematopoietic activities.

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Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent

Cited by 39 publications

References 14 publications

Ethnomedicinal, pharmaceutical and pesticidal uses ofCalotropis procera(Aiton) (Family: Asclepiadaceae)

Ethnomedicinal, pharmaceutical and pesticidal uses ofCalotropis procera(Aiton) (Family: Asclepiadaceae)

Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid

Subacute effect of Vernonia amygdalina methanolic crude leaf extract on the hematological profile in albino Wistar rats

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