Antineoplastic Actions of Cinnamic Acids and Their Dimers in Breast Cancer Cells: A Comparative Study

Hunke, Megan; Martínez, W; Kashyap, Akshay; Bokoskie, Treyvon; Pattabiraman, Mahesh; Chandra, Surabhi

doi:10.21873/anticanres.12749

Cited by 21 publications

(12 citation statements)

References 18 publications

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“…[30,31]. Medicinal activities of cinnamic acid derivatives have been reported such as anti-inflammatory, anti-oxidant, anti-viral, anti-microbial, anti-diabetic, neuroprotective and anti-tumor activities [30][31][32]. Cinnamic acid derivatives [33].…”

Section: Cinnamic Acid Derivativesmentioning

confidence: 99%

The Impact of Dietary Compounds in Functional Foods on MicroRNAs Expression

Chaiwangyen¹

2021

Functional Foods - Phytochemicals and Health Promoting Potential

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MicroRNAs (miRNAs) are a class of non-coding endogenous RNA molecules that are involved in post-transcriptional gene silencing via binding to their target messenger RNA, leading to mRNA degradation or translational repression. MicroRNAs can be modulated by several factors including hormones, transcription factors, and dietary compounds. These biologically active compounds have positive impact on the progression of human pathology including non-communicable diseases, which indicating that administration of diet may have potential as therapeutic agents in modulating the risk of chronic diseases. Interestingly, evidence emerging in recent years suggests that dietary miRNAs can be absorbed in human circulation, modulated human gene expression and biological functions. The exploitation of the miRNA functioning within different origins, cellular miRNAs and dietary miRNAs will help us to understand the molecular machinery as well as the regulatory mechanisms involved in fundamentally important biological processes. Therefore, this knowledge may be applied of natural bioactive compounds in preventive or therapeutic approaches.

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Section: Cinnamic Acid Derivativesmentioning

confidence: 99%

The Impact of Dietary Compounds in Functional Foods on MicroRNAs Expression

Chaiwangyen¹

2021

Functional Foods - Phytochemicals and Health Promoting Potential

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“…The widely reported anticancer potential of many natural or synthetic CAD [9,10,13,[33][34][35][36][37][38][39], and the antiproliferative properties of known antimalarial drugs, like chloroquine (2) [69] or quinacrine (4) [70,71], motivated the investigation of CA-antimalarial drug conjugates as anticancer leads. Hence, Pérez et al have investigated the antiproliferative activity of compounds 8 (Figure 2) on MKN-28 (gastric cancer), Caco-2 (colorectal adenocarcinoma), and MFC-7 (breast cancer) cell lines; all compounds were active in the micromolar range, while being non-toxic to the normal HFF-1 (human foreskin fibroblast) cell line.…”

Section: Repurposing Antimalarials For Cancer Via Conjugation To Cinnmentioning

confidence: 99%

“…Depending on their therapeutic targets, different modes of action seem to be exerted by CA and their derivatives or analogues. For instance, interactions with pathogens' membranes have been associated with the antimicrobial action of CA [30][31][32], whereas anticancer properties of different CA have been related to apoptosis [33][34][35][36][37][38][39], which encompasses various events including "S"-cycle arrest [34], cytoskeleton disruption [37], activation of caspases [38], generation of reactive oxygen species (ROS) [35,36], and inhibition of histone deacetylases [33,39].…”

Section: Introductionmentioning

confidence: 99%

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

et al. 2019

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Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.

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“…Accordingly, the anticancer activities of natural products and their synthetic derivatives have been extensively studied, primarily as chemopreventive and chemotherapeutic agents. 6 …”

Section: Introductionmentioning

confidence: 99%

Investigating the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer

Badawi¹,

Attia²,

El‐Kersh³

et al. 2022

IJN

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Purpose To design and optimize trans -cinnamic acid-loaded PLGA nanoparticles (CIN-PLGA-NPs) and assess its inhibitory effect on epithelial-mesenchymal transition (EMT) in triple-negative breast cancer. Methods The quality by design approach was used to correlate the formulation parameters (PLGA amount and Poloxamer188 concentration) and critical quality attributes (entrapment efficiency percent, particle size and zeta potential). Design of CIN-PLGA-NPs formulations was done based on central composite response surface design and formulated by nanoprecipitation method. In addition, the optimized CIN-PLGA-NPs formulation was further evaluated for morphology using transmission electron microscopy and in vitro dissolution test. The cytotoxicity of CIN-PLGA-NPs optimized formula in comparison to the free trans -cinnamic acid (CIN-Free) was investigated in vitro using MDA-MB-231, triple-negative breast cancer cells, followed by scratch wound assay for evaluating the impact on the migratory potential of MDA-MB-231 cells. In vivo antitumor activity was evaluated using Ehrlich ascites carcinoma solid tumor animal model where tumor volumes were measured at different time points and necrotic/apoptotic indices were estimated in tumor sections. EMT markers, E- and N-cadherin, were assessed in solid tumors as well. Results The optimized formulation showed entrapment efficiency of 76.98%, particle size of 186.3 nm with a smooth spherical surface and zeta potential of −28.47 mV indicating its stability. Furthermore, CIN-PLGA-NPs optimized formula released 60.8±1.89% of the total CIN-Free within 24 hours compared to 29±1.25% of the raw CIN-Free indicating improved dissolution rate. The optimized formula showed superior cytotoxicity on MDA-MB-231 cells compared to its free counterpart as well as increased wound closure percentage along with reduced tumor size in mice and increased necrotic and apoptotic indices. Tumor levels of E-cadherin and N-cadherin were indicative of EMT inhibition. Conclusion Our findings proved the capability of PLGA nanoparticles in loading trans -cinnamic acid in addition to enhancing its antitumor efficacy in triple-negative breast cancer possibly via inhibiting EMT.

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Antineoplastic Actions of Cinnamic Acids and Their Dimers in Breast Cancer Cells: A Comparative Study

Abstract: This study indicates an avenue for research for developing a novel class of antineoplastic compounds that can be synthesized using an easy, economical method.

Cited by 21 publications

References 18 publications

The Impact of Dietary Compounds in Functional Foods on MicroRNAs Expression

The Impact of Dietary Compounds in Functional Foods on MicroRNAs Expression

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

Investigating the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer

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