Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice

Abstract

A schiff base acetone semicarbazone has been synthesized and characterized. Its anticancer activities have been studied against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice by monitoring the parameters like tumour cell growth inhibition, tumour weight, survival time, peritoneal cells and haematological parameters. It was found that this compound significantly reduces tumour cell growth rate, decreases tumour weight and increases life span in comparison to those of EAC bearing mice. The test compound restored the depleted haematological parameters of EAC bearing mice towards normal. The compound also enhanced number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.

In vivo Antineoplastic Activities of Benzoin Thiosemicarbazone and Para-Anisaldehyde Semicarbazone against Ehrlich Ascites Carcinoma Cells

“…These compounds were synthesized according to the method described in the literature (10)(11)(12)(13)(14). For preparing BTSC, benzoin and thiosemicarbazide were mixed in 1:1 molar ratio, refluxed for a period of 3-4 h, and then distilled to half of the total volume.…”

“…In vivo tumor cell growth inhibition was carried out using the method as described (10)(11)(12) earlier. For this study, eight groups of mice (six in each group) were used.…”

Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper‐mediated cyclization

“…Thiosemicarbazones (TSCs) are a class of Schiffs base that are the condensation products of bioactive carbonyls and thiourea derivatives 11,12 . TSCs have manifested antiproliferative, antibacterial, antiviral, antifungal, antimicrobial, and antileukemic activities 13–18 . TSC derivatives with anticancer characteristics include marboran, amithiozone, cutisone, ambazone, and anisaldehyde TSCs.…”

“…11,12 TSCs have manifested antiproliferative, antibacterial, antiviral, antifungal, antimicrobial, and antileukemic activities. [13][14][15][16][17][18] TSC derivatives with anticancer characteristics include marboran, amithiozone, cutisone, ambazone, and anisaldehyde TSCs. Drugs like triapine and thiacetazone are also examples of bioactive TSCs.…”