Antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes

Wang, Huajie; Yang, Lin; Yang, Huayan; Wang, Kui; Yao, Wenguang; Jiang, Kai; Huang, Xiaolan; Zheng, Zhi

doi:10.1016/j.jinorgbio.2009.10.015

Cited by 26 publications

(15 citation statements)

References 24 publications

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“…Since Ksp of Ag 2 S is ῀10 -51 and its solubility in aqueous medium is 10 -15 g/L [40], even a fractional conversion in equation 5 obtained in the study can be used as an anti-microbial agent [55], in cancer treatment [56], fabrication of electric bistable devices [57], in semi-conducting devices [58], photo-sensitizer in photography and as a lab reagent.…”

Section: Silver Recovery Reuse and Recycling Of The Resin And The Rementioning

confidence: 99%

Silver recovery from greywater: Role of competing cations and regeneration

Nawaz

Sengupta

2017

Separation and Purification Technology

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The use of silver in consumer products and its subsequent leaching in greywater show an increasing trend. Silver recovery is not only commercially lucrative but also an environmental necessity. Trace concentration of Ag + and high concentration of other competing cations (Na + , Ca 2+ , Mg 2+) in a typical laundry wash water makes the separation process challenging. The use of ion-exchange resin with thiol group in its chain offers a potential solution due to its high selectivity for silver. This work successfully recovers silver (>90%) as high purity grade Ag 2 S powder (>99%) from synthetic greywater solution using a commercially available resin, Ambersep GT74, in a fixed-bed column mode. The regeneration process in the work has been optimized with respect to the solution pH and thiourea concentration (0.5 M thiourea concentration at pH 1). The resin and the regenerant have been used in multiple cycles (4 times) without compromising on their performance. The study successfully demonstrates a closed-loop sustainable scheme by reusing and recycling all the raw materials to the point of exhaustion with no chemicals/toxic released into the environment.

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Section: Silver Recovery Reuse and Recycling Of The Resin And The Rementioning

confidence: 99%

Silver recovery from greywater: Role of competing cations and regeneration

Nawaz

Sengupta

2017

Separation and Purification Technology

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“…Some in vivo studies have shown that the CdHgTe/gelatin nanospheres are immediately distributed to all over the vessels by blood circulation after injection. A network of blood vessels could be distinguished in fluorescence images, and the dynamic changes of nanospheres in the superficial vessels were clearly observed [78]. Although, these particles could be used as promising nanocarriers for proteins, DNA, and small molecules in the research of in situ , real time monitoring of drug release and therapy studies in the near future.…”

Section: Use Of Nanoparticles In Gliomas Diagnosismentioning

confidence: 99%

“…Recently, Wang et al observed cell death that might result from the interaction between mitochondria proteins and Ag + released from nanocrystals, which were predominantly endocytosed, and partly adhered to the membrane surface [78]. Even when high dosages can be achieved with nanocrystals and poorly soluble drugs can be formulated to increase their bioavailability via treatment with an appropriate coating layer, studies about the stability of nanocrystals and the cytotoxicity of these nanoparticles, with respect to their size and shape, are needed in order to advance in nanotechnology for tumor treatment, cure and to predict the possible toxic side effects on the body [18, 78]. …”

Section: Nanocrystalsmentioning

confidence: 99%

Application of Nanoparticles on Diagnosis and Therapy in Gliomas

Hernández‐Pedro

Rangel-López

Magaña-Maldonado

et al. 2013

BioMed Research International

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Glioblastoma multiforme (GBM) is one of the most deadly diseases that affect humans, and it is characterized by high resistance to chemotherapy and radiotherapy. Its median survival is only fourteen months, and this dramatic prognosis has stilled without changes during the last two decades; consequently GBM remains as an unsolved clinical problem. Therefore, alternative diagnostic and therapeutic approaches are needed for gliomas. Nanoparticles represent an innovative tool in research and therapies in GBM due to their capacity of self-assembly, small size, increased stability, biocompatibility, tumor-specific targeting using antibodies or ligands, encapsulation and delivery of antineoplastic drugs, and increasing the contact surface between cells and nanomaterials. The active targeting of nanoparticles through conjugation with cell surface markers could enhance the efficacy of nanoparticles for delivering several agents into the tumoral area while significantly reducing toxicity in living systems. Nanoparticles can exploit some biological pathways to achieve specific delivery to cellular and intracellular targets, including transport across the blood-brain barrier, which many anticancer drugs cannot bypass. This review addresses the advancements of nanoparticles in drug delivery, imaging, diagnosis, and therapy in gliomas. The mechanisms of action, potential effects, and therapeutic results of these systems and their future applications in GBM are discussed.

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“…The results in vitro and in vivo indicated that the resulting quantum dots had good stability, specificity and biocompatibility for ultrasensitive fluorescence imaging of molecular targets in the liver cancer model system. We also fabricated bovine serum albumin (BSA)-conjugated Ag 2 S nano-particles, nanorods and nano-wires in the previous work by a biomimetic method and found that the antineoplastic activity of different nano-materials on C6 glioma cells was dose-, size-and cell type-dependent [10,11].…”

Section: Introductionmentioning

confidence: 99%