Antineoplastic agent workplace contamination study: the Alberta Cancer Board Pharmacy perspective Phase III

Schulz, Heidi; Bigelow, Susan Jane; Dobish, Roxanne; Chambers, Carole

doi:10.1177/1078155208101097

Cited by 20 publications

(9 citation statements)

References 2 publications

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“…[27][28][29][30][31][32] The proportion of cyclophosphamide-positive samples (after cleaning) reported by Chu and others 16 was 57%, with values ranging from below LOD to 1.41 ng/cm 2 in pharmacy areas.…”

Section: Canadian Studiesmentioning

confidence: 99%

Environmental Contamination with Hazardous Drugs in Quebec Hospitals

Bussières¹,

Tanguay²,

Touzin³

et al. 2012

CJHP

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Section: Canadian Studiesmentioning

confidence: 99%

Environmental Contamination with Hazardous Drugs in Quebec Hospitals

Bussières¹,

Tanguay²,

Touzin³

et al. 2012

CJHP

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“…A total of 24 studies from 11 countries were included (Germany (n=3 studies), Australia (n=1), Belgium (n=3), Canada (n=6), the USA (n=2), France (n=2), Japan (n=3), the Netherlands (n=2), the UK (n=1), Sweden (n=2), Switzerland (n=1)) (online supplementary appendix 1). 4 5 10–31 Sampling was done by wiping the containers (n=20) or by immersion (n=3). Liquid chromatography tandem-mass spectrometry (n=15) and gas chromatography tandem-mass spectrometry (n=15) were mostly used to quantify the drugs.…”

Section: Resultsmentioning

confidence: 99%

External contamination of commercial containers by antineoplastic agents: a literature review

2019

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The aim of this study was to review the literature regarding the external contamination of commercial vials by antineoplastic drugs. A PubMed and CINAHL searches from 1 January 1990 to 1 May 2018 was performed with the terms: « antineoplastic agents », « environmental monitoring », « drug packaging », « vials » and « contamination ». Articles that presented results on the external contamination of commercial vials were included. Twenty-four articles were identified from 11 countries. A total of 4248 vials were sampled from 28 manufacturers. Traces were found on 56% (2379/4248) of vials. A maximum of 150 000 ng was measured on a glass vial of fluorouracil. This literature review showed that the exterior of the majority of commercial antineoplastic vials was contaminated. Manufacturers should limit this contamination. Centres are also encouraged to clean the vials on receipt. Personal protection equipment should be worn at all steps of the drug-use process.

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“…This is also supported by the contamination found on the prepared IV infusion bag in the initial assessment and the floor area under the infusion stand in the follow-up study. In addition, another source of potential contamination includes the fact that the external vials may also be contaminated [34–36]. Although somewhat expected, contamination inside the isolator and on the pharmacy bench can easily be transferred to prepared IV bags and further spread into the hospital environment.…”

Section: Discussionmentioning

confidence: 99%

Environmental Assessment of Cytotoxic Drugs in the Oncology Center of Cyprus

Soteriades

Economidou

Tsivitanidou

et al. 2019

Preprint

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BackgroundCytotoxic drugs constitute an important workplace hazard in the hospital environment. Our aim was to conduct an environmental assessment of hazardous drugs in the Oncology center of Cyprus. MethodsWipe samples were obtained from 42 workplace areas of the Oncology Center including two pairs of gloves in an initial assessment, while 10 samples were obtained at follow-up 3 years later.Potential contamination with cyclophosphamide (CP), ifosphamide (IF) and 5-fluorouracil (5-FU) and other cytotoxic medications was examined using the GC-MSMS system (CP, IF) and the HPLC system with UV detection (5-FU) method, respectively. ResultsWipe sample contamination was detected at 11.9% and 15% in the initial and follow-up assessment, respectively. Both pairs of gloves assessed were free from contamination. The results showed contamination with cyclophosphamide on the work space inside the isolator, on a day-care office phone and on the central pharmacy bench. Ifosphamide was only detected on the floor of a patient's room. Contamination with 5-fluorouracil was found only on the surface of a prepared IV infusion bag. The levels of contamination in the positive samples ranged from 0.05 to 10.12 ng/cm 2 . ConclusionsThe overall percentage of sample contamination at the Oncology Center was very low compared to other centers around the world. In addition, the detected levels of contamination with cytotoxic drugs were relatively low with the exception of the workspace inside the biological safety cabinet.These results in both assessments may reflect the implementation of comprehensive control measures including employee training, technological equipment and effective cleaning procedures.

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Antineoplastic agent workplace contamination study: the Alberta Cancer Board Pharmacy perspective Phase III

Abstract: results from this study prompted a decision to launch a Phase IV study to determine the feasibility within our network, for routine monitoring as well as sampling throughout the clean room beyond the BSC.

Cited by 20 publications

References 2 publications

Environmental Contamination with Hazardous Drugs in Quebec Hospitals

Environmental Contamination with Hazardous Drugs in Quebec Hospitals

External contamination of commercial containers by antineoplastic agents: a literature review

Environmental Assessment of Cytotoxic Drugs in the Oncology Center of Cyprus

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