Antineutrophil Cytoplasmic Antibodies in Children with Inflammatory Bowel Disease: Prevalence and Diagnostic Value

Olives, J. P.; Breton, A; Hugot, Jean‐Pierre; Oksman, F; Johannet, C.; Ghisolfi, J; Navarro, J.; Cézard, Jean-Pierre

doi:10.1097/00005176-199708000-00003

Cited by 50 publications

(24 citation statements)

References 26 publications

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“…As noted above, antibodies against neutrophils have been found in many but not all UC patients (13,63,70,81). However, the titers of antineutrophil antibodies do not seem to correlate with disease activity in UC (98), and their biological significance in UC patients is unclear.…”

Section: Autoimmune Diseasementioning

confidence: 99%

Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease

2002

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SUMMARY The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. In this review we delineate the clinical manifestations and diagnostic features of IBD. In addition, we summarize important recent advances in our understanding of the immune mediators of intestinal inflammation. This information has led to new therapeutic approaches in IBD. Further, we discuss the considerable data that point to the significance of genetic factors in the development of IBD and the genetic loci which have been implicated through genomewide searches. The commensal bacterial flora also appears to be a critical element, particularly in regards to Crohn's disease, although the precise role of the bacteria in the disease manifestations remains unclear. Current investigations promise to yield fresh insights in these areas.

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Section: Autoimmune Diseasementioning

confidence: 99%

Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease

2002

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“…pANCA are markers of immunological disturbance but they do not injure the tissue directly. pANCAs were also found in healthy first-degree relatives of patients with inflammatory bowel diseases (Olives et al 1997). The transient pANCAs positivity can thus be considered to reflect temporarily injured subtle mechanisms maintaining the balance between tolerance and immunity to dietary and bacterial antigens in the large bowel of infants.…”

Section: Resultsmentioning

confidence: 94%

Intestinal microbiota in exclusively breast-fed infants with blood-streaked stools

et al. 2009

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Intestinal microbiota in exclusively breast-fed infants with blood-streaked stools and in healthy exclusively breast-fed babies was compared. Total anaerobes, bifidobacteria, lactobacilli, coliform bacteria, enterococci and clostridia were quantified by cultivation methods in feces of 17 full-term exclusively breastfed patients (aged 16.3 +/- 7.4 weeks) with blood-streaked stools and in the control group of 22 healthy fullterm exclusively breast-fed infants (13.7 +/- 6.4 weeks). Specific fluorescence in situ hybridization kits for Bifidobacterium spp. were used for the quantitative detection of bifidobacteria in samples. Control samples had significantly (p < 0.05) higher counts of total anaerobes. Bifidobacteria were not detected in patients' samples in 65 % and in controls in 36 % (p < 0.01). Bifidobacteria counts were also significantly higher in the control group (p < 0.01). Furthermore, clostridia strains were detected only in feces from bifidobacteria-negative infants reaching counts >8 log CFU/g. Lactobacilli were not detected in 65 % patients and in 45 % control samples. However, this difference was not significant as well as the difference in lactobacilli counts. Eosinophilia was observed in 35 % of patients, low IgA concentration in 71 % and also low IgG concentration in 71 %. pANCA positivity was found in 53 % of patients. In conclusion a significant low proportion of bifidobacterial microbiota in patients with blood-streaked stools was shown in comparison with controls.

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“…Until now, several markers have been reported to help in the differential diagnosis of UC and CD. They include p-ANCA, ASCA, anti-OmpC antibody, and anti-I2 antibody [13,14,22,23]. Recently, antibodies to four peptides selected from a phage display library were reported to be detected in 57% of CD patients [24].…”

Section: Discussionmentioning

confidence: 99%