Antineutrophil cytoplasmic antibody-associated vasculitis in presence of positive antiphospholipid antibody: a case report 

Abstract

Background Antineutrophil cytoplasmic antibody-associated vasculitis is dominated by inflammatory occlusion of small vessels, causing tissue ischemia in various organs. This disorder has rarely been associated with vasculopathy, such as antiphospholipid syndrome. Case presentation We report a case of a 48-year-old Persian male presenting with distal digital gangrene along with inflammatory arthralgia. High titers of anti-proteinase 3 and antiphospholipid antibodies (anticardiolipin antibody) were detected in laboratory evaluation. Therefore, a diagnosis of antineutrophil cytoplasmic antibody-associated vasculitis and antiphospholipid syndrome was made and treated with anticoagulant along with monthly pulses of cyclophosphamide and a daily dose of 1 mg/kg prednisolone. Conclusion Our case, along with other reports, illustrates that these two entities can coexist. Therefore, monitoring antiphospholipid antibodies in patients with antineutrophil cytoplasmic antibody-associated vasculitis with or without clinical evidence of any thrombosis and ruling out thrombosis in cases that do not respond to proper treatment of vasculitis may be relevant to prevent irreversible or fatal organ damage.

COVID‐19 vaccine‐induced vasculitis in a patient with sarcoidosis: A case report

“…Neurological involvement and cutaneous vasculitis were the main focus of our study. Neutrophilic inflammation mostly in the superficial cutaneous postcapillary venules is defined as cutaneous vasculitis, 35 which in some cases can be secondary to infection, medication, and vaccination 12,36 . The onset and exacerbation of vasculitis symptoms have been reported during vaccinations against some viruses, such as influenza, hepatitis A and B, and Bacillus Calmette‐Guerin; however, cutaneous vasculitis following the COVID‐19 vaccine has been rarely reported in the literature 37,38 …”