Antinociception in the rat induced by a cold environment

Challenges of thermal nociceptive threshold testing in the donkey

“…There was no significant correlation between baseline surface skin temperature and TNT temperatures in Study 3 in contrast to studies in both humans and other animals where TNTs are higher when measured in cool ambient temperatures (Osgood et al. ; Strigo et al. ) but in our study there relatively small differences in ambient temperatures between the two environments, compared to the wider range of temperatures evaluated by other authors.…”

The Lower Pole of the Earlobe is an Alternative Site for Painless Blood Sampling in the Self-assessment of Blood Glucose Concentrations

“…Several studies have shown that moderately cool environmental temperatures produce an antinociceptive effect in animals (11,12), and that local skin cooling can produce coolrelated analgesia in humans (13,14). While data from human psychophysical and clinical studies are inconclusive (15, 16), we hypothesized that pain perception might be suppressed by cool ambient temperatures in humans.…”

The Assessment of Pain in the Burned Child and Associated Studies in the Laboratory Rat

“…It is unfortunate that there is, as yet, no way to study the effects of burn injury on physiological and pharmacological processes except by subjecting an animal to this trauma. We have, in fact, tried without success to replicate results of the endocrine effects of burns in rats exposed to warm (37° C) or cold (4° C) environments (Osgoodetal., 1986a;Osgood et al, 1990). The rat burn model is a long established, and until recent times, a widely accepted procedure for establishing an organism's response to burn injuries.…”

“…A cold environment has often been used to study the endocrine effects of burn injury (Aprille et al, 1979), with the assumption that responses to cold and burn stress are the same. Although these experiments led to a long and interesting study of stress analgesia induced by cold in the rat, it was apparent early on that the hormonal response to cold was clearly different from that of burn injury (Osgood et al, 1990). B-endorphin plasma levels, for example, except for a minor initial increase, declined steadily throughout the 2 hours in the cold.…”