Antinociception of β-d-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition

Baggio, Cristiane Hatsuko; Freitas, Cristina Setim; Marcon, Rodrigo; Werner, Maria Fernanda de Paula; Rae, Giles A.; Smiderle, Fhernanda Ribeiro; Sassaki, Guilherme L.; Iacomini, Marcello; Marques, Maria Consuelo Andrade; Santos, Adair R.S.

doi:10.1016/j.ijbiomac.2011.10.023

Cited by 45 publications

(28 citation statements)

References 34 publications

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“…The amount of time that the animal spent licking the injected paw was recorded with a chronometer over 5 min (for capsaicin or cinnamaldehyde) or 20 min (acidified saline and menthol) and used as an index of nociceptive behavior intensity. The doses were based on previous studies [41, 42]…”

Section: Methodsmentioning

confidence: 99%

Antinociceptive Activity of the Ethanolic Extract, Fractions, and Aggregatin D Isolated from Sinningia aggregata Tubers

et al. 2015

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The present study investigated the effects of the ethanolic extract (ESa), fractions, and compounds isolated from Sinningia aggregata in male Swiss mice on carrageenan-induced paw edema, neutrophil migration, mechanical hyperalgesia, formalin-induced nociception, and lipopolysaccharide-induced fever. The ESa did not alter edema, neutrophil migration, or fever at any of the doses tested. However, the ESa reduced phase II of formalin-induced nociception and carrageenan-induced mechanical hyperalgesia. The petroleum ether (PE) and ethyl acetate (EA) fractions and aggregatin D (AgD; isolated from the EA fraction) reduced formalin-induced nociception. Anthraquinones from the PE fraction were ineffective. AgD also inhibited carrageenan-induced mechanical hyperalgesia. Neither the ESa nor AgD altered thermal nociception or motor performance. Local administration of AgD also reduced hyperalgesia induced by carrageenan, bradykinin, tumor necrosis factor-α, interleukin-1β, cytokine-induced neutrophil chemoattractant, prostaglandin E2, and dopamine but not hyperalgesia induced by forskolin or dibutyryl cyclic adenosine monophosphate. The positive control dipyrone reduced the response induced by all of the stimuli. Additionally, glibenclamide abolished the analgesic effect of dipyrone but not the one induced by AgD. AgD did not change lipopolysaccharide-induced nitric oxide production by macrophages or the nociception induced by capsaicin, cinnamaldehyde, acidified saline, or menthol. These results suggest that the ESa has important antinociceptive activity, and this activity results at least partially from the presence of AgD. AgD reduced mechanical hyperalgesia induced by several inflammatory mediators through mechanisms that are different from classic analgesic drugs.

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Section: Methodsmentioning

confidence: 99%

Antinociceptive Activity of the Ethanolic Extract, Fractions, and Aggregatin D Isolated from Sinningia aggregata Tubers

et al. 2015

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“…In light of these considerations, polysaccharides recently became the focus of studies for the treatment of several disturbs. Recent works demonstrated that polysaccharides isolated from different sources exhibited important pharmacological activities, as antitumoral, immunomodulatory, antinociceptive and gastroprotective [30]–[33]. Interestingly, our group showed that the polysaccharide rhamnogalacturonan (RGal) isolated from A. oleracea protected the gastric mucosa against acute lesions induced by ethanol in rats, with an ED 50 of 1.5 mg/kg when administered by oral route.…”

Section: Discussionmentioning

confidence: 96%

Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: Gastroprotective and Ulcer Healing Properties in Rats

et al. 2014

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A rhamnogalacturonan (RGal) isolated from Acmella oleracea (L.) R.K. Jansen administered by oral route showed gastroprotective activity against acute lesions induced by ethanol. In this study, we investigated the gastric ulcer healing effect of RGal and its mechanisms of action. Intraperitoneal treatment of animals with RGal protected the gastric mucosa against acute lesions induced by ethanol, with participation of gastric mucus. Furthermore, in the chronic ulcer model, oral administration of RGal accelerates the gastric ulcer healing, accompanied by increasing of cellular proliferation and gastric mucus content, reducing inflammatory parameters and oxidative stress. In addition, the repeated 7 days-treatment of animals with RGal did not show alterations of clinical and behavioral symptoms, body and organs weights or plasmatic biochemical parameters. Collectively, these results showed that RGal has an interesting antiulcerogenic activity and could constitute an attractive molecule of interest for the development of new antiulcer agents.

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“…Investigations have proved the anti-oxidative properties of polysaccharides obtained from P. tuber-regium (Wu et al, 2014). A β-glucan obtained from P. pulmonarius has been found to exhibit analgesic and anti-inflammatory effects (Baggio et al, 2012).…”

Section: Polysaccharidesmentioning

confidence: 99%

Bioactive compounds and medicinal properties of Oyster mushrooms (Pleurotus sp.)

Golak-Siwulska

Kałużewicz

Spiżewski

et al. 2018

Folia Horticulturae

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There are about 40 species in the Pleurotus genus, including those with high economic significance, i.e. P. ostreatus and P. pulmonarius. The fruiting bodies of oyster mushrooms are of high nutritional and health-promoting value. In addition, many species belonging to the Pleurotus genus have been used as sources of substances with documented medicinal properties, such as high-molecular weight bioactive compounds (polysaccharides, peptides and proteins) and low-molecular weight compounds (terpenoids, fatty acid esters and polyphenols). The bioactive substances contained in the mycelium and fruiting bodies of Pleurotus species exhibit immunostimulatory, anti-neoplastic, anti-diabetic, anti-atherosclerotic, anti-inflammatory, antibacterial and anti-oxidative properties. Their multidirectional positive influence on the human organism is the result of interaction of bioactive substances. Extracts from individual Pleurotus species can be used for the production of dietary supplements increasing the organism’s immunity. They are also used for the production of cosmetics. They can be added to functional foods as probiotics, or used as natural preservatives or ingredients of special foodstuffs for patients with specific diseases.

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Antinociception of β-d-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition

Cited by 45 publications

References 34 publications

Antinociceptive Activity of the Ethanolic Extract, Fractions, and Aggregatin D Isolated from Sinningia aggregata Tubers

Antinociceptive Activity of the Ethanolic Extract, Fractions, and Aggregatin D Isolated from Sinningia aggregata Tubers

Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: Gastroprotective and Ulcer Healing Properties in Rats

Bioactive compounds and medicinal properties of Oyster mushrooms (Pleurotus sp.)

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