Antinociceptive Activities of Acetone Leaves Extracts of Carissa Spinarum in Mice

Jk, Mworia; Sm, Gitahi; Kk, Juma; Jm, Njagi; Bm, Mwangi; Umar, Aliyu; Wa, Njoroge; Kj, Mwonjoria; AM, Mawia; DW, Nyamai; Ngugi, Mathew Piero; Jjn, Ngeranwa

doi:10.4172/2167-0412.s1-006

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…The dose ranges employed in this study were within the dose ranges used in a study while evaluating the antipyretic effect of alcohol leaf and root bark extracts of Carissa edulis in rats [33]. Another study examining the antipyretic effect of methanolic extracts and various solvent fractions of Diospyros lotus used dose levels of 50 and 100 mg/kg body weight [34].…”

Section: Discussionmentioning

confidence: 99%

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

PM¹,

JK²,

Vz³

et al. 2016

J App Pharm

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Interest in herbal drugs is undergoing a renaissance at present time. Herbal agents are regarded to be more effective and comparatively safe as opposed to conventional medications which are relatively inaccessible and arguably associated with various adverse effects. Harrisonia abyssinica and Landolphia buchananii have been used by the Ameru and Embu communities to alleviate various ailments. However, despite their wide folklore use, extensive literature research reveals limited scientific evaluation of their described effects. Thus, the current study aimed to evaluate the antipyretic effects of their methanolic extracts. The plant samples were sourced from Mbeere, Embu County, Kenya. The test subjects (experimental rats) were grouped into four; normal group, a negative control group, reference group and experimental groups. The experimental groups were treated with stem bark extracts at concentration of 50 mg/kg, 100 mg/kg and 150 mg/kg. The determination of antipyretic activities was evaluated by using a 20% turpentine solution as the pyrexia inducing agent and then compared with aspirin as the reference drug. H. abyssinica extract reduced the rectal temperature by between 0.90% and 1.73% while L. buchananii extract reduced it by between 0.32% and 2.52%. Aspirin reduced the elevated rectal temperature by 1.70% and 2.32%. Qualitative phytochemical screening results showed that the extracts possessed several phytochemicals. The results of the study have confirmed the folklore use of the aforementioned plants in the suppression of pyrexia.

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Section: Discussionmentioning

confidence: 99%

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

PM¹,

JK²,

Vz³

et al. 2016

J App Pharm

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“…Extraction for all leaf samples, a modified procedure is reported by Mworia et al [24]. The leaves were picked, washed with tap water and dried at room temperature to remove the excess water.…”

Section: Preparation Of Natural Antifungal Extractsmentioning

confidence: 99%

Interaction of Natural Antifungals with Metal Hexacyanoferrates (II) and Its Medical Applications

Harris

Roberts

Tewari

2018

CJAST

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The study aimed to investigate the adsorptive interaction between metal hexacyanoferrates (II) and natural antifungals. Nickel, manganese and copper hexacyanoferrates (II) were synthesized and characterized by elemental and spectral analysis. The antifungal potentials of each metal hexacyanoferrate (II) at 10 mg/mL were combined with two natural antifungals: coconut (Cocos nucifera) and ochro (Abelmoschus esculentus) leaves. The ethanol and acetone extracts at 20 mg/mL and 10 mg/mL, respectively have been evaluated against fungus Candida albicans. The antifungal potential was executed by the disc diffusion method. The acetone and ethanol extract of A. esculentus at 10 mg/mL paired with copper and nickel ferrocyanides, respectively were found to possess the most effective antifungal potential. Each interaction pair was also characterized by spectral studies and phytochemical analysis.

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“…Carissa spinarum a medicinal plant used as both food and as medicine (Berhane et al, 2020) is a shrub found in the family Apocyneceae, survive at drought area and widely distributed in tropical regions (Fatima et al, 2013), used to treat several diseases, including gonorrhoea, diarrhea, sphillis, cough remedies (Ansari & Patit, 2018), viral diseases (Fatima et al, 2013), chest pains (Mworia et al, 2015), anti-inflammatory (Ansari & Patit, 2018). More over the parts of this plant exhibit antioxidant properies (Mundaragi & Thangadurai, 2018), a purgative, and be used to treat worms (Harwansh et al, 2010).…”

Section: List Of Figuresmentioning

confidence: 99%

Fabrication of liposome-chitosa N-ZnO nanohybrid integrated with Carissa Spinarum extract for antibacterial application

Rubaka

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Innovative biomaterials provide a stimulating and adaptable platform for the implementation of new and more effective methods to prevent bacterial infection. Built on biomimetic inorganic hybrid material, Dual Nanohybrid Delivery System (DN-DS) has advantageous properties for biomedical applications, such as the delivery of herbal formulations for the treatment of bacterial infections. Using microwave assisted extraction (MAE), the polyphenols of Carissa spinarum were extracted. The Dual Nanohybrid Delivery System (LipCsP-ZnONPs)-CT was formed by combining LipCsP-Chitosan and ZnO-Chitosan, which were both generated using different methods of co-precipitation and ion gelation, respectively. A Zetasizer was used to characterize the nanosystems' size, zeta potential, and polydispersity index (PDI). A UV-visible spectrophotometer was utilized for the optical study, and a scanning electron microscope was employed to investigate at the surface morphology. The interaction of coated chitosan with liposomes and ZnONPs was evaluated using Fourier Transformation Infrared (FTIR) spectroscopy. Different kinetic models were fitted to the results of the encapsulation and release profiles of polyphenols in the liposome nanosystems to determine the mechanism of release. Antibacterial activity of the nanoformulations was assessed by an agar diffusion assayand the micro plate blue assay (MABA). The Zeta potential of LipCsP changed from -45.3 ± 0.78 to +34.43 ±1.36 due to chitosan coatings. Polyphenol-encapsulation efficiency was higher in LipCsP-Chitosan (81 ± 2.5%) than in LipCsP (66.11 ± 1.11%). Conversely, the size of LipCsP (176.17 ± 1.05 nm) increasedto 365.2 ± 0.70 nm. FTIR analysis revealed the interaction of the liposome with chitosan due to the disappearance of N-H primary amine. Interaction between chitosan and zinc oxide was revealed by the formation of new absorption peaks at 670 cm-1 and 465 cm-1 as observed in the FTIR analysis. (LipCsP-ZnONPs)-CT presented high bioaccessibility of polyphenols in the simulated gastric phase (82.14 ± 0.80%) than in simulated intestinal phase (71.60 ± 0.86%), a stable system for sustained release of polyphenols, and prominent antibacterial activity. (LipCsP-ZnONPs)-CT exhibited a relative inhibition zone diameter (RIZD) of 89.60 ± 1.32, significant high viability reduction (P˂0.05) against Klebsiella pneumoniae as compared to LipCsP-Chitosan and ZnO-chitosan. The nanohybrid systems (LipCsP-Chitosan and ZnO chitosan) exhibited synergistic effect against Klebsiella pneumoniae. This study successfully demonstrated the utility of the nanohybrid as a potential antibacterial agent against K. ii pneumoniae, therefore, the fabricated dual nano delivery system is an efficacy material for treatment of pneumococcal infections.

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Antinociceptive Activities of Acetone Leaves Extracts of Carissa Spinarum in Mice

Abstract: Mworia et al., Med Aromat Plants 2015, S1 http://dx

Cited by 4 publications

References 18 publications

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats

Interaction of Natural Antifungals with Metal Hexacyanoferrates (II) and Its Medical Applications

Fabrication of liposome-chitosa N-ZnO nanohybrid integrated with Carissa Spinarum extract for antibacterial application

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