Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats

Arambewela, L.S.R.; Arawwawala, L.D.A.M.; Ratnasooriya, W.D.

doi:10.1016/j.jep.2004.07.015

Cited by 47 publications

(39 citation statements)

References 21 publications

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“…It has already been reported that two species of Alpinia, leaves of A. zerumbet (de Araujo et al, 2005) and rhizomes of A. calcarata (Arambewela et al, 2004), exhibit analgesic activities via the opioid receptor. It is quite interesting that the opioid receptor was not involved in the antinociceptive activity of A. katsumadai (Fig.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Choi¹,

Kim²,

Yeom³

et al. 2010

Biomolecules and Therapeutics

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-Alpinia katsumadai has been widely used in traditional Chinese and Korean medicine to treat a variety of conditions including emesis and gastric disorders such as gastric pain and distended abdomen. To investigate the antinociceptive potential and mechanism of A. katsumadai, ethanolic extracts of A. katsumadai were assayed on cyclooxygenase-2 and evaluated for analgesic activity based on phenylbenzoquinone (PBQ)-induced writhing and carrageenan-induced hyperalgesia tests. A. katsumadai extracts inhibited the cyclooxygenase-2 enzyme activity in a dose-dependent fashion at an IC50 value of 0.044 μg/ml. A. katsumadai extract (30-300 mg/kg, orally (p.o.) administered) significantly inhibited PBQ-induced writhing. This inhibition was judged not to be a false positive because a Rota-rod test revealed no difference in muscular coordination when compared to the controls. With regard to the carrageenan-induced hyperalgesia, A. katsumadai extract (30-300 mg/kg, p.o.) produced a significant, dose-dependent increase in the withdrawal response latencies. Naloxone did not reverse the analgesic effect of A. katsumadai extract in the carrageenan-induced hyperalgesia. Taken together, these results suggest that the antinociceptive activity of A. katsumadai is not related to the opioid receptor. A. katsumadai extract has remarkable, non-opioidreceptor-mediated analgesic effects on PBQ-induced writhing and carrageenan-induced hyperalgesia that occur via cyclooxygenase-2 inhibition.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Choi¹,

Kim²,

Yeom³

et al. 2010

Biomolecules and Therapeutics

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“…Prior to use, the dried A. conchigera rhizome ethanol extract (ACRE) was emulsified using 0.1% Tween 80 in normal saline to the doses of 30, 100, and 300 mg/kg body weight for administration to the animals (Hosseinzadeh et al, 2000). The doses used were based on a previous study using other species of Alpinia (Arambewela et al, 2004).…”

Section: Preparation Of Ethanol Extract Of Alpinia Conchigera Rhizomesmentioning

confidence: 99%

“…In addition, Yu et al (1988) reported that A. conchigera fruits contained anti-inflammatory producing compounds, such as phenylpropanoid derivatives, chavicol acetate, and uegenol acetate. Several species of Alpinia have also been reported to possess different types of pharmacological activities (Fonteles & Leal-Cardoso, 1999;Tewtrakul et al, 2003;Arambewela et al, 2004;Araújo Pinho et al, 2005). The present study investigated the potential antinociceptive and anti-inflammatory properties of the ethanol extract of A. conchigera rhizomes on experimentally induced pain and inflammation, and also aimed to elucidate its mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of the ethanol extract ofAlpinia conchigerarhizomes in various animal models

Sulaiman

Zunita

Mohamad

et al. 2010

Pharmaceutical Biology

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“…Alpinia calcarata rhizomes have a broad spectrum of medicinal properties. The rhizomes of Alpinia calcarata are known to possess antibacterial, anthelmintic, antifungal [6], antioxidant [7]. Aphrodisiac [8], gastroprotective [9], antidiabetic and anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Antioxidant and Anticancer Activity of Alpinia Calcarata and Alpinia Galanga

Vijayalakshmi

Rengarajan²,

Thangavel

2017

Int J Pharm Pharm Sci

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Objective: The present study was to determine in vitro antioxidant and anticancer activity of Alpinia calcarata and Alpinia galanga. Methods:The phytochemical screening of rhizome of aqueous extract of Alpinia calcarata and Alpinia galanga was performed using standard procedures. The total phenolic and flavonoid content were determined by Folin-Ciocalteau and Aluminium chloride reagents. The various antioxidant assays and cytotoxic assays (MTT) for Alpinia calcarata and Alpinia galanga was performed using standard methods (DPPH radical scavenging assay, Nitric oxide radical scavenging assay, Reducing power assay, Phosphomolybdenum reduction assay). Results:The preliminary phytochemical screening of Alpinia calcarata and Alpinia galanga showed the presence of flavonoids, phenols, terpenoids, carbohydrates and proteins. The phenolic content of aqueous extracts of rhizomes of Alpinia calcarata was 454.05 μg/mg and Alpinia galanga was 480.13 μg/mg and was expressed as gallic acid equivalent. The flavonoid content of aqueous extracts of rhizomes of Alpinia calcarata was 36.34 μg/mg and Alpinia galanga was 67.68 μg/mg and was expressed as quercetin equivalent. In DPPH assay, Alpinia galanga showed 95.36% whereas Alpinia calcarata showed 54.54% at 120 μg/ml. The maximum NO • Conclusion:The results obtained in the present study indicate that rhizome of Alpinia galanga are abundant in phenols and flavanoids which may be useful for the development of the anticancer drug. radical scavenging activity was 59.44% for Alpinia calcarata and was 73.10% for Alpinia galanga at 120 µg/ml concentration. The maximum reducing property was found at the 120 μg/ml of aqueous extract of rhizomes of Alpinia galanga which was higher than the Alpinia calcarata. In Phosphomolybdenum assay, the aqueous extracts of rhizomes of Alpinia calcarata and Alpinia galanga were 55.47% and 78.38% respectively. The results of the present investigation indicated that rhizome of aqueous extract of Alpinia galanga showed the highest antioxidant activity in all the assays than Alpinia galanga. The cytotoxicity assay results indicated that rhizome of aqueous extract of Alpinia galanga showed 88.36% cell viability whereas Alpinia calcarata showed 73.59% cell viability.

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Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats

Cited by 47 publications

References 21 publications

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Antinociceptive and anti-inflammatory effects of the ethanol extract ofAlpinia conchigerarhizomes in various animal models

Comparative Study of Antioxidant and Anticancer Activity of Alpinia Calcarata and Alpinia Galanga

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