Antinociceptive Activities of the Hydroalcoholic Extracts from Erythrina velutina and Erythrina mulungu in Mice

Vasconcelos, Silvânia Maria Mendes; Oliveira, G. R. De; Carvalho, Manuella Mohana de; Rodrigues, Alexandre César Praxedes; Silveira, Edilberto R.; Fonteles, M.M.F.; Sousa, Francisca Cléa Florenço de; Viana, Glauce Socorro Barros

doi:10.1248/bpb.26.946

Cited by 56 publications

(39 citation statements)

References 16 publications

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“…Some researches already showed many effects of these species in rodents, like the sedative and neuromuscular blocking actions from the crude extract from the leaves of E. velutina (Dantas et al, 2004), the antinociceptive and the depressant activities of the hydroalcoholic extracts (HAE) from the stem bark of both species (Vasconcelos et al, 2003;2007) and the anxiolytic effect of the HAE from the inflorescence of E. mulungu and from the stem bark of E. velutina (Onusic et al, 2003;Sarragiotto et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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This work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan-and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the present work, the extracts were administered orally in male mice at the doses of 200 or 400 mg/kg. In the carrageenan-induced test, only Em showed anti-inflammatory activity, decreasing the paw edema, at the doses of 200 and 400 mg/kg. No effect was observed with Ev in this model. On the other hand, in the dextran model, Ev demonstrated anti-inflammatory effect, showing decrease of the paw edema at the 1, 2, 3, 4 and 24 th h. Em (200 or 400 mg/kg) presented antiinflammatory effect at the 2, 3 and 4 th h after administration of dextran, as compared to control. In conclusion, the work showed that Ev and Em present anti-edematous actions, which possibly occurs by distinct mechanisms. While Ev seems to interfere especially in inflammatory processes in which mast cells have an important role, Em exerts greater activity in the inflammatory process that depends mainly on polymorphonuclear leucocytes. However, further studies are needed to determine the exact mechanism of action of the species investigated.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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“…At least 110 species of the genus Erythrina have been identified (1) and many of them are native to the American continent (2).…”

Section: Introductionmentioning

confidence: 99%

<a name="home"></a>Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression

Ribeiro

Onusic

Poltronieri

et al. 2006

Braz J Med Biol Res

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Erythrina velutina (EV) and Erythrina mulungu (EM), popularly used in Brazil as tranquilizing agents, were studied. The effects of acute and chronic oral treatment with a water:alcohol extract of EV (7:3, plant grounded stem bark; acute = 100, 200, 400 mg/kg; chronic = 50, 100, 200 mg/kg) were evaluated in rats (N = 11-12) submitted to the elevated T-maze (for avoidance and escape measurements) model of anxiety. This model was selected for its presumed capacity to elicit specific subtypes of anxiety disorders recognized in clinical practice: avoidance has been related to generalized anxiety and escape to panic. Additionally, animals were treated with the same doses of EV and EM (water:alcohol 7:3, inflorescence extract) and submitted to the forced swim test for the evaluation of antidepressant activity (N = 7-10). Both treatment regimens with EV impaired elevated T-maze avoidance latencies, without altering escape, in a way similar to the reference drug diazepam (avoidance 1, mean ± SEM, acute study: 131.1 ± 45.5 (control), 9.0 ± 3.3 (diazepam), 12.7 ± 2.9 (200 mg/kg), 28.8 ± 15.3 (400 mg/kg); chronic study: 131.7 ± 46.9 (control), 35.8 ± 29.7 (diazepam), 24.4 ± 10.4 (50 mg/kg), 29.7 ± 11.5 (200 mg/kg)). Neither EV nor EM altered measurements performed in the forced swim test, in contrast to the reference drug imipramine that significantly decreased immobility time after chronic treatment. These results were not due to motor alterations since no significant effects were detected in an open field. These observations suggest that EV exerts anxiolytic-like effects on a specific subset of defensive behaviors which have been associated with generalized anxiety disorder.

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“…Sex hormones are known to regulate the reproductive function and characteritics in both male and female organism. Measurement of serum hormone profile is therefore very useful in assessing the reproductive integrity in both animals and humans [7]. In view of continual consumption of the Erytherina senegalensis in treatment of diseases and paucity of literatures on the leaf extract, the present study is aimed to evaluate the effect of ethanolic leaf extract of E. Senegalensis on the oestrogen level and histology of the ovary of albino wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

Tn¹,

Dn²,

Cs³

et al. 2017

Anat Physiol

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Erytherina senegalensis are used in soups administered after delivery, also in Nigeria; it is given to women during labour to ease pain, for treatment of malaria, gastrointestinal disorders, fever, dizziness, secondary sterility, diarrhoea, jaundice, nose bleeding, pain, bronchial infection, coughs, throat inflammation and administered for venereal diseases. In view of its usage, the study sought to investigate the effect of Erytherina senegalensis leaf extract on the oestrogen level and the histology of the ovary of albino wistar rat. Fresh mature leaf samples of E. senegalensis were collected, ethanolic extract was prepared and the effect of sub-chronic oral administration of the leaf extract of E. senegalensis was studied using twenty-five female albino wistar rats. The oral administration of the leaf extract was done three times per week, for 60 days at doses of 2000 mg/kg for group 1, 4000 mg/kg for group 2, 6000 mg/kg for group 3, 8000 mg/kg body weight for group 4 and group 5 is the control group, received distilled water and food alone. The rats were anaesthetised by chloroform in a close jar and blood samples were for hormonal test, experimental rats were sacrificed by cervical dislocation and the ovary harvested. There was a dose dependent increase in the level of oestrogen across the groups and there was no significant alteration on the histology of the ovary across the groups. Oestrogen level and histology architecture reveals the leaf extract didn't show any sign of toxicity on the hormone and organ of the study, this may suggest that the extract may be used as female hormonal supplement and may not be toxic when administered orally.

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Antinociceptive Activities of the Hydroalcoholic Extracts from Erythrina velutina and Erythrina mulungu in Mice

Cited by 56 publications

References 16 publications

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

<a name="home"></a>Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

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