Antinociceptive activity of Calotropis procera latex in mice

Soares, Paula Matias; Lima, Silvane R.; Matos, Samara G.; Andrade, Marcelo M.; Patrocínio, Manoel Cláudio Azevedo; Freitas, Cléverson D.T.; Ramos, Márcio V.; Criddle, David N.; Cardi, Bruno A.; Carvalho, Karine Maria Martins Bezerra; Assreuy, Ana Maria Sampaio; Vasconcelos, Silvânia Maria Mendes

doi:10.1016/j.jep.2005.02.010

Cited by 61 publications

(35 citation statements)

References 16 publications

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“…gigantea (synonymn: Calotropis procera) was noted to be used by the Bede practitioners for treatment of pain in 8 different formulations, most of which included treatment of rheumatic pain. Notably, latex of the plant possesses antinociceptive properties (Soares et al, 2005); thus there is scientific validation for its traditional use by the Bedes as an analgesic. Rheumatism is a disease for which allopathic medicine has no curable treatment, and so persists life-long in a person, who has the disease.…”

Section: Discussionmentioning

confidence: 99%

Tribal Formulations for Treatment of Pain: A Study of the Bede Community Traditional Medicinal Practitioners of Porabari Village in Dhaka District, Bangladesh

Seraj

Jahan

Chowdhury

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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The Bedes form one of the largest tribal or indigenous communities in Bangladesh and are popularly known as the boat people or water gypsies because of their preference for living in boats. They travel almost throughout the whole year by boats on the numerous waterways of Bangladesh and earn their livelihood by selling sundry items, performing jugglery acts, catching snakes, and treating village people by the various riversides with their traditional medicinal formulations. Life is hard for the community, and both men and women toil day long. As a result of their strenuous lifestyle, they suffer from various types of pain, and have developed an assortment of formulations for treatment of pain in different parts of the body. Pain is the most common reason for physician consultation in all parts of the world including Bangladesh. Although a number of drugs are available to treat pain, including non-steroidal, steroidal, and narcotic drugs, such drugs usually have side-effects like causing bleeding in the stomach over prolonged use (as in the case of rheumatic pain), or can be addictive. Moreover, pain arising from causes like rheumatism has no proper treatment in allopathic medicine. It was the objective of the present study to document the formulations used by the Bede traditional practitioners for pain treatment, for they claim to have used these formulations over centuries with success. Surveys were conducted among a large Bede community, who reside in boats on the Bangshi River by Porabari village of Savar area in Dhaka district of Bangladesh. Interviews of 30 traditional practitioners were conducted with the help of a semi-structured questionnaire and the guided field-walk method. It was observed that the Bede practitioners used 53 formulations for treatment of various types of pain, the main ingredient of all formulations being medicinal plants. Out of the 53 formulations, 25 were for treatment of rheumatic pain, either exclusively, or along with other types of body pain. A total of 65 plants belonging to 39 families were used in the formulations. The Fabaceae family provided 7 plants followed by the Solanaceae family with 4 plants. 47 out of the 53 formulations were used topically, 5 formulations were orally administered, and 1 formulation had both topical and oral uses. 8 formulations for treatment of rheumatic pain contained Calotropis gigantea, suggesting that the plant has strong potential for further scientific studies leading to discovery of novel efficacious compounds for rheumatic pain treatment.

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Section: Discussionmentioning

confidence: 99%

Tribal Formulations for Treatment of Pain: A Study of the Bede Community Traditional Medicinal Practitioners of Porabari Village in Dhaka District, Bangladesh

Seraj

Jahan

Chowdhury

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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“…Detecting the presence of active molecules in a plant extract is the first strategy in the study of potentially therapeutic plants (Soares et al, 2005). Indeed, the identification of active compounds is an important method to understand how such molecules trigger their pharmacological activities.…”

Section: Discussionmentioning

confidence: 99%

The anti-inflammatory and antinociceptive effects of proteins extracted from Acacia farnesiana seeds

Leal

Silva

Araújo

et al. 2016

Rev. bras. plantas med.

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Seeds of Acacia farnesiana are commonly sold in the local markets of northeastern Brazil as a therapeutic agent. The present work aimed to evaluate the anti-inflammatory and analgesic activities of proteins obtained from A. farnesiana seeds. Five different protein fractions (albumin, globulin, prolamin, acidic and basic glutelins) were obtained and investigated for the protein pattern, the presence of hemagglutinating and proteolytic activities. The globulin fraction (GLB) was also evaluated for anti-inflammatory and analgesic activities. Globulins reduced the paw edema induced by carrageenan in a dose-dependent manner, which was accompanied by a reduction of myeloperoxidase activity (p < 0.05). Additionally, GLB reduced the neutrophil peritoneal migration induced by carrageenan. However, GLB was not able to inhibit the edema triggered by dextran. Pre-treatment with globulins reduced the abdominal constrictions induced by acetic acid as well as the paw licking time induced by formalin (69.1% at first phase). However, it did not produce a significant antinociceptive effect in the hot plate test (55-56 °C). Treating the GLB with heat (at 100 °C for 30 min) abolished its anti-edematogenic and hemagglutinating activities. Our results showed that seeds from A. farnesiana are a source of proteins with antiinflammatory and analgesic properties.Keywords: cysteine proteinase, Coronha, inflammation, lectin, nociception RESUMO: Efeito antiiflamatório e antinociceptivo de proteínas extraídas de sementes de Acacia farnesiana. Sementes de Acacia farnesiana são comumente vendidas em feiras locais no nordeste do Brasil como agente terapêutico. O presente trabalho objetivou avaliar as atividades antiinflamatória e antinociceptiva de proteínas obtidas de sementes de A. farnesiana. Cinco frações protéicas distintas (albuminas, globulinas, prolaminas, glutelinas ácidas e básicas) foram obtidas e investigadas quanto o perfil de proteínas, presença de atividade hemaglutinante e proteolítica. A fração globulina (GLB) também foi avaliada quanto a presença de atividade antiinflamatória e analgésica. Globulinas reduziram o edema de pata induzido por carragenina de modo dependente da dose que foi acompanhada da redução da atividade da mieloperoxidase (p < 0,05). Em adição, GLB reduziu a migração de neutrófilos para cavidade peritoneal induzida por carragenina. Entretanto, GLB não foi capaz de inibir o edema induzido por dextrana. O pré-tratamento com globulinas reduziu as contorções abdominais induzidas por ácido acético, bem como o tempo de lambedura da pata induzida por formalina (69.1% na primeira fase). Por outro lado, GLB não produziu um efeito antinociceptivo significante no teste de placa quente (55-56 °C). O pré-tratamento de GLB com calor (100 °C por 30 min) aboliu sua atividade anti-edematogênica e hemaglutinante. Nossos resultados mostraram que sementes de A. farnesiana são fonte de proteínas com propriedades antiinflamatórias e analgésicas.

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“…The root bark in the form of paste with rice vinegar is applied to elephantiasis of the legs and scrotum. It also acts as an emetic in doses of 30 to 60 g and has been used as a substitute for ipecacuanha [2][3][4][5][6][7][8][9] .…”

Section: Fig 1: Calotropis Proceramentioning

confidence: 99%

Untitled

2010

IJPSR

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Calotropis procera (Asclepiadaceae) is an erect, perennial shrub luxuriantly thriving in wastelands. It is commonly distributed in most parts of India and also distributed in Persia, tropical Africa and other tropical countries of the World. The aqueous extract of some parts have laxative property and beneficial in skin diseases, ulcers, enlargement of the spleen, abdominal glands, liver diseases, promotes digestive power and also useful in colics. The milky exudate is useful in skin diseases, tumour and ascitis. It is a very good purgative. Here an attempt has been taken to evaluate the antioxidant activity, CNS depressant activity and also antimicrobial activity of methanolic extract of fresh flowers of C. procera. In result, the methanolic flower extract showed a significant activity against DPPH free radicals and the IC 50 value is 64.87µg/ml. On the other hand, CNS depressant activity of the extract was also observed by using In Vivo model. In antimicrobial activity five different fungal species were inhibited by this extract and from the above study the flowers extract showed the maximum zone of inhibition against Candida parapsiliasis and the minimum against P. notatum ATCC 11625. Simultaneously, four different bacteria were inhibited in the concentration of 1mg/ml up to 4mg/ml flower extract of C. procera showing significant zone of inhibition against those.

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Antinociceptive activity of Calotropis procera latex in mice

Cited by 61 publications

References 16 publications

Tribal Formulations for Treatment of Pain: A Study of the Bede Community Traditional Medicinal Practitioners of Porabari Village in Dhaka District, Bangladesh

Tribal Formulations for Treatment of Pain: A Study of the Bede Community Traditional Medicinal Practitioners of Porabari Village in Dhaka District, Bangladesh

The anti-inflammatory and antinociceptive effects of proteins extracted from Acacia farnesiana seeds

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