Antinociceptive activity of Cistanche salsa stolons, growing in the Republic of Kazakhstan

Картбаева, Э.Б.; Donald, Graciela Rocha; Sakipova, Zuriyadda; Ibragimova, Liliya; Bekbolatova, Elmira; Ternynko, Inna I.; Fernandes, Patrícia Dias; Boylan, Fábio

doi:10.1016/j.bjp.2017.05.013

Cited by 12 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to note that several peaks observed in the chromatogram remain unidentified, and their identification could potentially provide valuable insights into the phytochemical characterization of this species, particularly if they turn out to be phenylethanoid glycosides. As previous research on phytochemicals from parasitic plants has placed significant emphasis on these phenylethanoid glycosides due to their occurrence exclusively in parasitic plants and their notable antioxidant properties ( Kartbaeva et al, 2017 ; Jedrejek and et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

In this current study, we explored the preventive capacity of the aqueous extract of Orobanche foetida (OF), a root holoparasite, against CCl4 prompt hepatotoxicity in rats. LC-MS/MS profiling revealed the existence of 32 compounds belonging to organic acids, benzoic acid derivatives, and hydroxycinnamic acids along with their glycosides and derivatives as well as several flavonoids. In vitro, OF demonstrated substantial antioxidant potential at DPPH and ABTS assays. Results showed that the pretreatment with OF for 6 weeks at the doses (25 mg/kg bw) and (50 mg/kg bw) countered the CCl4-induced liver injury by restoring liver injuries indicators (ALT, AST, LDH, ALP, GGT and bilirubin), normalizing lipid profile (TC, TG, LDL-C, and HDL-C), as well as, impeding DNA fragmentation. Furthermore, OF blocked the hepatic oxidative stress spurred by CCl4 administration through boosting antioxidant enzymes (GSH, CAT, and SOD) responsible of diminishing lipid peroxidation. exhibited an anti-inflammatory effect by downregulating TNF-α and IL-6 levels. OF suppressive effect on proinflammatory cytokines is further exerted by its capacity to modulate the expression of the NF-κB gene. In silico investigation revealed that among the 32 identified compounds, vanillic acid glucoside and dihydroxybenzoic acid glucoside have strong and stable bindings with the active sites of three key inflammatory proteins (PARP-1, TNF-α, IL-6), which could highlight the antioxidant and anti-inflammatory capacity of. Overall, this research provides a preliminary pharmacological support for the medicinal applications of Orobanche foetida for addressing inflammatory and hepato-pathological conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The flora of Southern Kazakhstan, not yet fully explored in terms of its chemical composition and biological activity, can be regarded as a rich reservoir of several medicinal plants with novel potential applications [ 14 , 15 , 16 , 17 , 18 ]. Phytochemical analysis of the hydroethanolic extracts obtained from the aerial parts of T. marschallianus Willd and T. seravschanicus Klokov growing widely in Southern Kazakhstan has indicated that there were several differences in the composition of the metabolites, as revealed by HPLC/ESI-QTOF-MS.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan

et al. 2021

View full text Add to dashboard Cite

The chemical composition of the hydroethanolic extracts (60% v/v) from the aerial parts of Thymus marschallianus Willd (TM) and Thymus seravschanicus Klokov (TS) from Southern Kazakhstan flora was analyzed together with their hexane fractions. Determination of antibacterial, antifungal and antioxidant activities of both extracts was also performed. RP-HPLC/PDA and HPLC/ESI-QTOF-MS showed that there were some differences between the composition of both extracts. The most characteristic components of TM were rosmarinic acid, protocatechuic acid, luteolin 7-O-glucoside, and apigenin 7-O-glucuronide, while protocatechuic acid, luteolin 7-O-glucoside, luteolin 7-O-glucuronide, and eriodictyol predominated in TS. The content of polyplenols was higher in TS than in TM. The GC-MS analysis of the volatile fraction of both examined extracts revealed the presence of thymol and carvacrol. Additionally, sesquiterpenoids, fatty acids, and their ethyl esters were found in TM, and fatty acid methyl esters in TS. The antioxidant activity of both extracts was similar. The antibacterial activity of TS extract was somewhat higher than TM, while antifungal activity was the same. TS extract was the most active against Helicobacter pylori ATCC 43504 with MIC (minimal inhibitory concentration) = 0.625 mg/mL, exerting a bactericidal effect. The obtained data provide novel information about the phytochemistry of both thyme species and suggest new potential application of TS as a source of bioactive compounds, especially with anti-H. pylori activity.

show abstract

“…For example, the reported contents of echinacoside and verbascoside in C. salsa (10.98 mg g −1 and 9.44 mg g −1 , respectively) [42], and poliumoside in C. sinensis (3.4-36.2 mg g −1 ) [43] are similar to the ones obtained for T. montanum extract (echinacoside: 23.54 mg g −1 dw, verbascoside: 7.90 mg g −1 dw, poliumoside: 21.72 mg g −1 dw). In comparison to the study of Esposito et al (2020) [44] on Ajuga reptans L. extract as a well-known source of teupolioside (2.8% on dry weight of extract), T. montanum seems to be a potentially valuable source as well (6.93 mg g −1 dw).…”

Section: Determination Of Hc and Phenolic Compounds In Extractmentioning

confidence: 99%

A Novel Approach to Serving Plant-Based Confectionery—The Employment of Spray Drying in the Production of Carboxymethyl Cellulose-Based Delivery Systems Enriched with Teucrium montanum L. Extract

Mandura Jarić,

Haramustek,

Nižić Nodilo

et al. 2024

Foods

View full text Add to dashboard Cite

In this study, spray drying was used as a technological solution for the valorization of Teucrium montanum extract into carboxymethyl cellulose-based delivery systems (CMC), individually or in combination with collagen, guar gum, gum arabic, and kappa-carrageenan. The results showed that the process yield and morphological properties were positively influenced by the introduction of CMC binary blends. The employment of CMC resulted in a high encapsulation efficiency (77–96%) for all phenylethanoid glycosides (PGs) analyzed. Due to the low wettability of the microparticles, a relatively gradual in vitro release of the PGs was achieved. Infusion of the filling with hydrophilic T. montanum extract encapsulated in microparticles with high hydrophobic surface area proved to be a practical route for significant confectionery fortification (5–9 mg PGs per dw serving), ensuring prolonged interaction between the food matrix used and the extract under simulated gastrointestinal conditions. Based on sensory evaluation, the introduction of kudzu starch into the jelly matrix has shown a texture-modifying potential.

show abstract

Antinociceptive activity of Cistanche salsa stolons, growing in the Republic of Kazakhstan

Cited by 12 publications

References 18 publications

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan

A Novel Approach to Serving Plant-Based Confectionery—The Employment of Spray Drying in the Production of Carboxymethyl Cellulose-Based Delivery Systems Enriched with Teucrium montanum L. Extract

Contact Info

Product

Resources

About