Antinociceptive activity of fractions from Couroupita guianensis Aubl. leaves

Pinheiro, Mariana Martins Gomes; Bessa, Sidnei O.; Fingolo, Catharina Eccard; Kuster, Ricardo Machado; Matheus, Maria Eline; Menezes, Fábio S.; Fernandes, Patrícia Dias

doi:10.1016/j.jep.2009.10.025

Cited by 52 publications

(34 citation statements)

References 17 publications

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“…Similarly, our data were consistent with previous studies showing that PH has antinociceptive effects in a non-dose dependent manner. Acetic acid-induced writhing has been used as a screening tool to assess analgesic or anti-inflammatory agents (Pinheiro et al, 2010). The release of mediators involved in acetic acid stimulation, such as histamine, serotonin, and cytokines, helps to increase vascular permeability, reduce the threshold of nociception, and stimulate the nerve terminal of nociceptive fibers (da Silva Guerra et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Wang

Jia

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Paecilomyces hepiali (PH), a well-known medicinal fungus, has various pharmacological efficacies. In our study, the antinociceptive effects of PH and underlying mechanisms were evaluated using various mouse models. An acetic acid-induced writhing test, hot plate test, and formalin test were employed to evaluate the antinociceptive activities of PH. The levels of neuronal nitric oxide synthase (nNOS) in the hypothalamus and monoamine neurotransmitters in the serum and hypothalamus of experimental mice were examined. Additionally, hot plate tests using mice pretreated with various antagonists were used to determine the mechanisms of PHmediated antinociception. The PH-enhanced latency period of mice in the hot plate test was significantly blocked by pretreatment with atropine and glibenclamide. PH shortened the phase I and phase II reaction times of formalin-treated mice. Strongly reduced writhing and stretching induced by acetic acid were observed in PH-treated mice, indicating that PH mainly exerts antinociceptive activity on neurogenic pain. After thermal pain stimulation for 30 s, compared to control mice, 7-day PH-treated mice had lower nNOS and dopamine levels, and increased levels of serotonin in both the serum and hypothalamus. Collectively, our data showed that PH mediated antinociceptive activities via multiple pathways, including monoamines, nNOS/ATPsensitive K + channels, and M-type acetylcholine receptors.

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Section: Discussionmentioning

confidence: 99%

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Wang

Jia

et al. 2016

Genet. Mol. Res.

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“…Em estudos biológicos de espécies da família Lecythidaceae foram demonstradas ações antiartrítica, antifúngica, antiprurítica (FRANCO;BARROS, 2006;HUSSIN et al, 2009;PATIL et al, 2011), cicatrizante de feridas tópicas (McRAE et al, 2008) e as folhas, lores e cascas da espécie Couroupita guianensis (espécie popularmente conhecida no Brasil como abricó-demacaco) são usadas na América do Sul na forma de chás ou infusões para tratar dor e inlamação (PINHEIRO et al, 2010).…”

Section: Ação Carrapaticida Da Espécie Lecythis Luridaunclassified

Ação carrapaticida sobre Rhipicephalus microplus dos extratos, frações e compostos obtidos da espécie Lecythis lurida (Lecythidaceae)

et al. 2015

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ResumoO Rhipicephalus microplus destaca-se entre os ectoparasitas de maior importância econômica na bovinocultura. O controle do carrapato bovino tem sido diicultado pela resistência de populações aos acaricidas sintéticos. Dessa forma, o objetivo do trabalho foi avaliar a eiciência carrapaticida de extratos, frações e metabólitos secundários de Lecythis lurida no combate ao R. microplus. Esse é o primeiro relato de estudo químico e biológico da espécie L. lurida, conhecida no cerrado leste do Maranhão, onde foi coletada, como sapucarana. Destaca-se pela sua densidade populacional e também pela exuberância de sua loração, muito visitada por várias espécies de abelhas. A investigação química revelou que os compostos obtidos da espécie L. lurida se agrupam na classe dos triterpenos, entre eles o friedelanol e a friedelina, esse último, como composto majoritário, além de misturas de triterpenos e esteroides. A avaliação da atividade carrapaticida sobre larvas e fêmeas ingurgitadas de carrapatos da espécie R. microplus revelou que apenas alguns extratos e frações apresentaram atividade moderada, considerando como parâmetros as concentrações testadas dos extratos e frações obtidos a frio e a quente de folhas e cascas de L. lurida.

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“…Writhing test was carried out as described by Pinheiro et al,(2010) and Mariana et al, (2012). [10,11] In brief, the mice were pre-treated with positive drug and test drug for 3 days; approximately a half hour after the final administration on the third day, 0.6% acetic acid (0.1mL/10g) was given by intraperitoneal injection.…”

Section: Writhing Testmentioning

confidence: 99%

“…[10,11] In brief, the mice were pre-treated with positive drug and test drug for 3 days; approximately a half hour after the final administration on the third day, 0.6% acetic acid (0.1mL/10g) was given by intraperitoneal injection. The number of writhing movements during the next 15 minutes was recorded.…”

Section: Writhing Testmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of roots extracts from Actinidia arguta (Sieb.et Zucc.) Planch

Teng¹,

Hong-sheng²,

Zhang³

2014

Phcog J.

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Aims: The roots of Actinidia arguta (Sieb. et Zucc.) Planch (also named tengligen) have medicinal uses as anti-tumour, antinociceptive, and anti-inflammatory agents. In this study, we evaluated the antinociceptive and anti-inflammatory effects of 95% ethanol extract and different fractions of the roots of A. arguta (Sieb.et Zucc.) Planch (Tengligen). Methods: Three conventional methods were used to carry out the antinociceptive effect: acetic acid-induced abdominal writhing, formalin induced hind paw licking, and hot plate test. In addition, the anti-inflammatory effect was investigated by carrageenan-induced paw edema in rats. Conclusion: From the obtained results, we found that the total ethanol extract, ethyl acetate fraction, and n-butanol fraction all significantly inhibited acetic acidinduced writhing and both phases of the formalin induced pain response, increased the time of response to thermal stimulation in hot plate test, and exhibited significant dose-related inhibition of carrageenan induced paw edema volumes when compared with the control group. Based on our findings, we conclude that the flavonoid and saponin contents of tengligen are responsible for the antinociception and anti-inflammatory effects of Actinidia arguta (Sieb. et Zucc.) Planch, respectively.

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Antinociceptive activity of fractions from Couroupita guianensis Aubl. leaves

Abstract: Results obtained demonstrated that Couroupita guianensis CEE and its fractions have antinociceptive activity that is mediated, at least in part, by opioid and cholinergic systems and nitric oxide pathway.

Cited by 52 publications

References 17 publications

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Ação carrapaticida sobre Rhipicephalus microplus dos extratos, frações e compostos obtidos da espécie Lecythis lurida (Lecythidaceae)

Antinociceptive and anti-inflammatory effects of roots extracts from Actinidia arguta (Sieb.et Zucc.) Planch

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