Antinociceptive Activity of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Mice Model

PM, Nthiga; JK, Kamau

doi:10.4172/2167-0846.1000253

J Pain Relief

2016

DOI: 10.4172/2167-0846.1000253

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Antinociceptive Activity of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Mice Model

Nthiga PM¹,

Kamau JK²

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2024

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Bio efficacy of methanol leaf extracts of Cissampelos pareira Linn., Lantana camara Linn. and Ocimum gratissimum Linn. against fever in Wistar rats

Kimuni,

Gitahi,

Ngugi

et al. 2024

Acta Marisiensis - Seria Medica

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Objective This study evaluated antipyretic potency of methanol extracts of Cissampelos pareira, Lantana camara and Ocimum gratissimum in Wistar rats. Methods The leaves samples were obtained from Embu County, Kenya. Quantitative phytochemical analysis of the extracts was conducted using LC-MS and GC-MS methods. The study was performed in eight sets each with 5 Wistar rats (n = 5): positive control, normal control, negative control as well as experimental. Group I (normal control) rats were injected intraperitoneally with a solution of Dimethyl sulfoxide (DMSO) only. Group II (negative control) constituted rats initiated with fever using turpentine alongside DMSO. Group III, (positive control) rats were induced with pyrexia and then administered with aspirin. Groups IV, V, VI, VII, and VIII composed of turpentine-induced pyretic rats that were intraperitoneally injected with various extracts dosages. The data was analysed using Statistical Package for Social Sciences (v25) software. Results The plant extracts possess antipyretic activities that are comparable to the standard therapy, aspirin. Quantitative phytochemistry showed that the extracts contained bioactive principles such as terpenoids, flavonoids, and alkaloids which exert antipyretic activity. Conclusion The studied plants are rich in secondary metabolites that have antipyretic efficacies in rats. Hence, this study validates the folkloric use of the tested plants to manage fever among the Mbeere community in Kenya.

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Bio efficacy of methanol leaf extracts of Cissampelos pareira Linn., Lantana camara Linn. and Ocimum gratissimum Linn. against fever in Wistar rats

Kimuni,

Gitahi,

Ngugi

et al. 2024

Acta Marisiensis - Seria Medica

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show abstract

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Antinociceptive Activity of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Mice Model

Cited by 1 publication

References 29 publications

Bio efficacy of methanol leaf extracts of Cissampelos pareira Linn., Lantana camara Linn. and Ocimum gratissimum Linn. against fever in Wistar rats

Bio efficacy of methanol leaf extracts of Cissampelos pareira Linn., Lantana camara Linn. and Ocimum gratissimum Linn. against fever in Wistar rats

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