Antinociceptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. Leaves extract

Zhou, Minhua; Wang, Honggang; Suolangjiba,; Kou, Junping; Yu, Boyang

doi:10.1016/j.jep.2008.02.005

Cited by 108 publications

(61 citation statements)

References 18 publications

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“…The intraperitoneal administration of agents that irritate serous membranes provokes a stereotyped behaviour in the mice which is characterized by abdominal contractions, movements of the body as a whole and twisting of the dorso-abdominal muscles [22] and a reduction in motor activity and motor incoordination [23]. It has been suggested that acetic acid injection into peritoneal cavity leads to increased levels of cyclooxygenases (COX) and lipoxygenase [24] and indirectly leads to the release of endogenous nociceptive mediators such as PGE 2 and PGF 2α [5,20,[25][26][27][28][29][30], serotonin [22,25,26,29,30], histamine [22,26,30,31], bradykinin [21,22,24], substance P [24,25], cytokines (TNF-α, IL-1β, IL-8) [21,24,25,29] and lipoxygenase products [20], which eventually excites the primary afferent nociceptors [25] that contribute to the development of inflammatory pain [22]. The data presented in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Intraplantar injection of formalin has been reported to produce a distinct biphasic nociceptive response [12,21], termed first and second phases [20]. The first phase, commonly denominated early or neurogenic phase (from 0 to 5 min after injection formalin) results from a direct stimulation of nociceptors (predominantly C-fibres) [22,23,27,28,31,32,34]. Substance P, glutamate and bradykinin are thought to participate in this phase, which is believed to be non-inflammatory pain [28].…”

Section: Discussionmentioning

confidence: 99%

“…This model of nociception, predominantly a spinal reflex, is thought to involve supraspinal nociceptive processing [21,27] and has often been used to assess central antinociceptive activity [25,28]. The central analgesics activate the release of endogenous peptides via the periaqueductal gray matter (PAG), which is then carried to the spinal cord to inhibit the pain impulse transmission within the dorsal horn [25].…”

Section: Discussionmentioning

confidence: 99%

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Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea (Aubl.) Jacks in vivo

Díaz¹,

Cruz²,

Gupta³

et al. 2017

JPP

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Abstract:The present study was conducted to evaluate the antinociceptive and anti-inflammatory activities of methanol extract of rachis of Ormosia coccinea (Aubl.) Jacks (MEOC) using animal models of nociception and inflammation. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Oral administration of MEOC (500 mg/kg) produced significant (p < 0.05) antinociceptive effects when tested in mice using acetic acid-induced abdominal writhing test and on the inflammatory phase of the formalin test. It was also demonstrated that MEOC had no significant effect on the response latency time to the heat stimulus in the thermal model of the hot plate test. The anti-inflammatory activity of the extract was assessed using carrageenan, histamine and serotonin induced oedema in rat paw. The oral administration of MEOC showed maximum inhibition (64.29%) at 1 h on carrageenan edema, but it did not modify the edema induced by histamine and serotonin. The present results suggest that MEOC has a peripheral antinociceptive and anti-inflammatory action.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea (Aubl.) Jacks in vivo

Díaz¹,

Cruz²,

Gupta³

et al. 2017

JPP

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“…A atividade analgésica do ECPCS foi avaliada pela técnica de contorções abdominais induzidas pelo ácido acético que inclui estimulo nociceptivo periférico e central para fornecer resposta de analgesia frente ao dano tecidual induzido pelo ácido, todavia, essa técnica tem maior empregabilidade sobre a ação álgica periférica (Zhou et al, 2008;Steranka et al, 1987;Wang et al, 2013;Habib & Waheed, 2013). A ação nociceptiva do ácido acético desencadeia a liberação de substâncias químicas endógenas (Gyires & Torna, 1984;Berkenkopf, et al, 1988).…”

Section: Discussionunclassified

Atividade Antinociceptiva e Antimicrobiana da Casca do Caule de Psidium Cattleyanum Sabine

Alvarenda

Royo

Mota

et al. 2015

Rev. bras. plantas med.

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RESUMO:Psidium cattleyanum Sabine, conhecida como "araçá", é espécie nativa do Bioma Cerrado brasileiro comumente utilizado, segundo levantamento etnobotânico, como planta medicinal para tratar várias doenças tais como: patologias hepáticas, gástricas, lesões teciduais incluindo processos dolorosos. O objetivo deste trabalho foi realizar a triagem fitoquímica com propósito exploratório, investigar a atividade analgésica e antimicrobiana do extrato hidroalcoólico da casca do caule de Psidium cattleyanum Sabine (ECPCS) para apoiar o uso dessa espécie como planta medicinal. Para isso, foram obtidos extratos e frações com solventes orgânicos de polaridade crescente (hexano, diclorometano, acetato de etila e isobutanol) avaliando-se o perfil fitoquímico para determinar as principais classes de metabólitos secundários presentes na espécie. Investigou-se a atividade analgésica pelo teste de contorções abdominais em camundongos induzidas pelo ácido acético (0,6%). A Concentração Inibitória Mínina (CIM) e Concentração Bactericida Mínima (CBM) foram avaliadas através da técnica de microdiluição em caldo contra micro-organismos da microbiota oral. A triagem fitoquímica identificou a presença de taninos, saponinas, flavonoides e terpenos e/ou esteroides. O ECPCS exibiu atividade analgésica periférica nas doses de 200 e 400 mg/kg. O EAC (extrato acetato de casca) o EDC (extrato diclorometânico de casca) desempenharam melhor ação inibitória sobre o crescimento bacteriano de Estafilococos oralis com CIM 100 e 150 respectivamente. O ECPCS desempenhou ação inibitória sobre o crescimento bacteriano. Os resultados dos estudos experimentais comprovaram a presença de compostos secundários tais como, taninos e flavonoides, o que, provavelmente, pode ser associado à atividade analgésica e ao efeito inibitório sobre os micro-organismos testados com o ECPCS, o que justifica o uso medicinal planta.Palavras Chave: Myrtaceae, araçá, atividade biológica, inibição álgica, atividade antibacteriana.ABSTRACT: Antiniciceptive and antimicrobial activity of the stem bark of Psidium cattleyanum Sabine. The Psidium cattleyanum Sabine, known as "araçá", is a native species from the Brazilian Cerrado biome, commonly used, according to ethnobotanical surveis, as a medicinal plant to treat several sicknesses such as liver and , gastric diseases and tissue lesions with painful treatments. The aim of this study was to perform an exploratory screening, investigating the analgesic and antimicrobial activity of the hydroalcoholic extract of the Psidium cattleyanum Sabine (BEPCS) stem bark, in order to support the use of this species as a medicinal plant. For that, the BEPCS and its parts were obtained from the extraction with organic solvents of increasing polarity (hexane, dichloromethane, ethyl acetate and isobutanol), evaluating its phytochemical profile in order to determine the main types of secondary metabolites present in the species. The analgesic activity, through the twisting test in mice, was investigated and induced by acetic acid (0.6%). The Min...

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“…The test was carried out using the described technique previously (Zhou et al, 2008). Mice were injected intraperitoneally with 0.1 ml/10 g body weight of 0.6 % acetic acid in saline solution 0.5 h after the topical administration of tested drugs in the abdomens.…”

Section: Acetic-acid-induced Writhing Response In Micementioning

confidence: 99%

Evaluation of Effectiveness in a Novel Wound Healing Ointment-Crocodile Oil Burn Ointment

Li¹,

Deng²,

Zhang³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation -crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. The analgesic and anti-inflammatory activities of COBO were also studied to provide some evidences for its further use. Materials and methods:The wound healing potential of this formulation was evaluated by employing a deep second-degree burn rat model and the efficiency was comparatively assessed against a reference ointment -(1% wt ⁄ wt) silver sulfadiazine (SSD). After 28 days, the animals were euthanized and the wounds were removed for transversal and longitudinal histological studies. Acetic acid-induced writhing in mice was used to evaluate the analgesic activity and its anti-inflammatory activity was observed in xylene -induced edema in mice. Results: COBO enhanced the burn wound healing (20.5±1.3 d) as indicated by significant decrease in wound closure time compared with the burn control (25.0±2.16 d) (P<0.01). Hair follicles played an importance role in the physiological functions of the skin, and their growth in the wound could be revealed for the skin regeneration situation. Histological results showed that the hair follicles were well-distributed in the post-burn skin of COBO treatment group, and the amounts of total, active, primary and secondary hair follicles in post-burn 28-day skin of COBO treatment groups were more than those in burn control and SSD groups. On the other hand, the analgesic and anti-inflammatory activity of COBO were much better than those of control group, while they were very close to those of moist exposed burn ointment (MEBO). Conclusions: COBO accelerated wound closure, reduced inflammation, and had analgesic effects compared with SSD in deep second degree rat burn model. These findings suggest that COBO would be a potential therapy for treating human burns.

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Antinociceptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. Leaves extract

Cited by 108 publications

References 18 publications

Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea (Aubl.) Jacks in vivo

Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea (Aubl.) Jacks in vivo

Atividade Antinociceptiva e Antimicrobiana da Casca do Caule de Psidium Cattleyanum Sabine

Evaluation of Effectiveness in a Novel Wound Healing Ointment-Crocodile Oil Burn Ointment

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