Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin

Abstract

Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

Fabrication and Evaluation of Rotary Separator of Sesame Oil

“…Substance= Rotation velocity of cylinder 0.0358 -Radius of rotation 0.0943 + 1.11 (Rotation velocity of cylinder Radius of rotation) + 6.45 (4) According to Figures 4, it can be claimed that the speed of centrifuges and the radius of the rotating cylinder are correlated with the amount of solids (debris) of sesame oil. Using a cylinder with a radius of 175 mm, it was observed that the highest amount of pulp in the sesame seed oil was at 3500 and 7.4 percent, and the lowest amount of pulp in the 5500 and 4.4 percent, respectively.…”

“…This oil has a long and lasting resistance to high-fat unsaturated edible oils [3]. The natural antioxidants in this oil have a high resistance to oxidation and valuable physiological properties of sesame oil [4]. Sesame seeds contain 30-50% oil and 20-30% protein [5].…”

Beneficial effect of Burdock complex on asymptomatic Helicobacter pylori‐infected subjects: A randomized, double‐blind placebo‐controlled clinical trial

“…Several studies indicated that lignans (artigenin, arctiin, and lappaol F) of Arctium lappa (burdock) could hamper the expression of various proinflammatory cytokines such as IL‐6, TNF‐α via inhibiting nuclear factor kappa B (NF‐κB) in different models . Monteiro and his colleagues concluded that sesame oil and sesamin (lignin) could impede leukocyte migration or infiltration as well as downregulate various proinflammatory cytokines due to the rich content of PUFA and thus confer its anti‐inflammatory activity . However, CLAR also lowered the inflammatory response owing to its bacteriostatic and anti‐adhesion properties .…”

“…31,32 Monteiro and his colleagues concluded that sesame oil and sesamin (lignin) could impede leukocyte migration or infiltration as well as downregulate various proinflammatory cytokines due to the rich content of PUFA and thus confer its anti-inflammatory activity. 33 However, CLAR also lowered the inflammatory response owing to its bacteriostatic and anti-adhesion properties. 34 The results of this in vitro studies emphasize that burdock complex can exhibit anti-adhesive and anti-inflammatory activities and thus abolish H. pylori infection without displaying direct bactericidal property.…”

Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review

“…Sesamin, one of the major lignans in sesame seed and flax, possesses various beneficial functions, including anti-oxidative [105], lipid-lowering (arachidonic acid [106] and cholesterol [107] levels), anti-hypertensive [108], neuroprotective [109], anti-tumor [110], and anti-inflammatory [111] actions. Sesamin also plays a unique role in improving the bioavailability of T3 in vitro [112] and in vivo [113].…”