Antinociceptive and Anti-inflammatory Activities ofViburnum lantana.

Abstract

Water extract of Viburnum lantana L. (Caprifoliaceae) (VL) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VL causes dose-related inhibition in acetic acid-induced abdominal stretching in mice. VL inhibited abdominal stretching at 100 mg=kg, which is similar to that of aspirin, but this extract exhibited stronger antinociceptive activity than aspirin at a 200 mg=kg dose. VL showed powerful antinociceptive activity, which was quantified by a tail-flick test in 100 mg=kg dose. The anti-inflammatory activity of VL was not found to be significantly different at doses of 100 and 200 mg=kg. As a result, VL had shown slight antiinflammatory activity compared with indomethacin. The LD 50 of VL was determined as 2.169 g=kg.

Gas Chromatography-Mass Spectrometry Analysis of Viburnum Opulus (L) Extract and Its Toxicity Studies in Rats

“…The biological activities of medicinal plants are associated with the type and nature of secondary plant metabolites they contain. The phytochemical investigation which showed the presence of tannins, saponins, phenols, flavonoids, terpenoids, and steroids (Table 1) is in line with the previous studies as reported by Yilmaz et al [4]. From the antimicrobial screening (Table 2), the butanol fraction was the most effective against the entire microorganism tested having a zone of inhibition ranging from 6 to 9 mm as compared with other fraction with no activity.…”

“…It constitutes four different species in the native of Turkey; which includes Viburnum lantana L., Viburnum orientale Pallas, Viburnum tinus L., and Viburnum opulus L. [2]. The genus has medicinal uses ranging from antispasmodic, diuretic, hepatoprotective, antiinflammatory, and antisedative effects [3,4]. A local drink called "gilaburu" was formulated from the fruit of V. opulus in Middle Anatolia while the bark of V. lantana is known for its analgesic potential [5].…”

Genus Viburnum: Therapeutic Potentialities and Agro‐Food‐Pharma Applications

“…Viburnum lantana L. leaf water extract was investigated for anti-inflammatory activity, in rats with a carrageenaninduced rat paw edema test. The anti-inflammatory activity of the extract at doses of 100 and 200 mg/kg has been low as compared to indomethacin [169].…”

“…Among these plants, the species of the genus Viburnum are of interest. For that purpose, anti-inflammatory activities of V. lantana, V. trilobum, V. pichinchense, V. sargentii, V. fordiae, and V. opulus were investigated [78,[166][167][168][169][170].…”

Phytochemical analysis of Viburnum davidii Franch. and cholinesterase inhibitory activity of its dihydrochalcones

“…Yet, many other species, such as V. trilobum Marshall, V. cotinifolium D.Don, V. grandiflorum Wall. ex DC., V. opulus L., V. nervosum D.Don and V. lantana L., have been used in ethnomedicine for their high anti-inflammatory, antidiabetic, sedative, antispasmodic, antiasthmatic, antiarrhythmic, antitumor, antimicrobial and antinociceptive properties (Yılmaz et al 2007; Van et al 2009;Awan et al 2013;Saltan et al 2016).…”