Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

Suárez, Alírica I.; Compagnone, Reinaldo S.; Salazar-Bookaman, Maria Margarita; Tillett, Stephen; Monachè, Franco Delle; Giulio, Camilo Di; Bruges, Gustavo

doi:10.1016/s0378-8741(03)00179-x

Cited by 30 publications

(17 citation statements)

References 12 publications

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“…(Thongtan et al 2003), antinociceptive and anti-inflammatory properties of Croton malambo Karst. (Su arez et al 2003). Our group has also demonstrated the antiulcerogenic potential of C. campestris roots in rodents (Brito J unior et al 2013(Brito J unior et al , 2014.…”

Section: Introductionmentioning

confidence: 84%

Oxidant effects and toxicity ofCroton campestrisinDrosophila melanogaster

Júnior

Macedo

Zemolin

et al. 2016

Pharmaceutical Biology

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Context: Croton campestris A.St.-Hil. (Euphorbiaceae) is a species native to Northeast Brazil used by traditional communities for the treatment of a variety of health problems. However, potential toxicological effects of this plant are unknown. Objective: The potential toxicity of the hydroalcoholic extract of C. campestris leaves on Drosophila melanogaster insect model, additionally with phytochemical constitution and cellular mechanisms mediating the action of extract were analysed in this study. Materials and methods: Constituents of the extract were evaluated by HPLC. In vitro antioxidant potential of extract was analysed by DPPH, ABTS and FRAP. Flies injected culture medium mixed with extract (0.1-50 mg/mL) for 72 h. After, ROS production was evaluated by DCF-DA oxidation. Phosphorylation of MAPK signalling pathway was investigated by Western blotting method. Activity of antioxidant enzymes was analysed in homogenates.Results: Major components of the extract include quercetin (38.11 ± 0.06 mg/g), caffeic acid (20.06 ± 0.17 mg/g) and kaempferol (15.45 ± 0.05 mg/g). Consumption of the extract impaired locomotor performance and induced fly death of flies (LC 50 of 26.51 mg/mL). Augmented ROS formation and SOD, CAT and GST activity were observed from 0.1 mg/mL. JNK and p38 kinases phosphorylation was modulated and Paraquat-induced toxicity was augmented by extract. Discussion and conclusion: Our data show important toxicological effects of C. campestris leading to increased mortality and impaired locomotor performance accompanied by induction of cell stress markers in flies. The study draws attention to the indiscriminate use of plant extracts. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 84%

Oxidant effects and toxicity ofCroton campestrisinDrosophila melanogaster

Júnior

Macedo

Zemolin

et al. 2016

Pharmaceutical Biology

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“…6 The aqueous extract of C. malambo bark administered intraperitoneally showed antinociceptive and anti-inflammatory effects, comparable to acetylsalicylic acid and sodium diclofenac. 161 C. celtidifolius bark has anti-inflammatory activity. 12 …”

Section: Anti-inflammatory and Antinociceptivementioning

confidence: 99%

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

401

320

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Croton é um gênero de Euphorbiaceae com cerca de 1300 espécies, amplamente distribuídas em regiões tropicais do Novo e Velho Mundos. Várias espécies há muito tempo desempenham papel importante nos usos tradicionais de plantas medicinais na África, Ásia e América do Sul. Tais usos incluem tratamento de câncer, constipação intestinal, diarréia e outros problemas digestivos, diabetes, feridas externas, febre, hipercolesterolemia, hipertensão, inflamação, vermes intestinais, malária, dor, úlceras e obesidade. Várias espécies de Croton têm um látex vermelho que contém, em algumas espécies, pró-antocianidinas e/ou alcalóides. Os alcalóides de Croton são a taspina ou substâncias relacionadas a benzilisoquinolinas. Os diterpenos são muito comuns em Croton, correspondendo a clerodanos, cembranóides, halimanos, cauranos, labdanos, ésteres do forbol, traquilobanos e sarcopetalanos. Algumas espécies são aromáticas, devido à presença de óleos voláteis. Representantes de novas classes de substâncias (fenilbutanóides, alcalóides glutarimidínicos e diterpenos sarcopetalanos) têm sido isoladas de espécies de Croton. Enquanto laticíferos têm sido descritos em espécies de Croton, até o momento não há estudos anatômicos sobre estruturas secretoras de óleos voláteis. Parece haver afinidades químicas no gênero relacionadas à geografia, agrupando espécies com (i) cauranos e/ou labdanos, (ii) traquilobanos e (iii) alcalóides. Os ensaios farmacológicos freqüentemente vêm corroborando os usos tradicionais de espécies de Croton. Grande parte dos ensaios farmacológicos trata do clerodano trans-desidrocrotonina, envolvendo uma grande diversidade de efeitos, incluindo hipolipidêmico, hipoglicêmico, antiestrogênico e anticâncer. Efeitos citotóxicos também vêm sendo observados em ensaios com alcalóides (taspina) e com diterpenóides secocaurenos, labdanos e cembranóides. Vários outros efeitos de substâncias de Croton têm sido relatados, incluindo anti-hipertensivos, antiinflamatórios, antimaláricos, antimicrobianos, antiespasmódicos, antiulcerogênicos, antivirais e mio-relaxantes.Croton is a genus of Euphorbiaceae comprising around 1,300 species, widespread in tropical regions of the Old and New Worlds. Several species have a long role in the traditional use of medicinal plants in Africa, Asia and South America. Popular uses include treatment of cancer, constipation, diabetes, digestive problems, dysentery, external wounds, fever, hypercholesterolemia, hypertension, inflammation, intestinal worms, malaria, pain, ulcers and weight-loss. Several species of Croton have a red sap, in some species containing proanthocyanidins and/or alkaloids. The latter may be taspine or some of several benzylisoquinoline-like compounds. Diterpenes are very common in Croton, corresponding to clerodanes, cembranoid, halimanes, kauranes, labdanes, phorbol esters, trachylobanes and sarcopetalanes. Some species are aromatic due to the possession of volatile oils. Representatives of new classes of compounds (phenylbutanoids, glutarimide alkaloids, sarcopetalane diterpen...

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“…The methanolic extract from J. curcas has insecticidal activity against Helicoverpa armigera (Lepidoptera) and Sitophilus zeamais (Coleoptera) (Solsoloy, 1995), and Culex quinquefasciatus (Diptera) (Karmegam et al, 1997). Although innumerous species of the genus Croton (Euphorbiaceae) present several biological activities (Peres et al,1997 and1998;Suárez et al, 2003;Anazetti et al, 2004;Fisher et al, 2004), there are no reports for Croton urucurana on insecticidal, deterrent, repellent activities or inhibiting action on insects' digestive enzymes. Anagasta kuehniella (Zeller) (Lepidoptera: Pyralidae), popularly known as Mediterranean flour moth is found worldwide, particularly in the stored grains as a flour and grain feeder: it is often a severe pest in flour mills.…”

Section: Introductionmentioning

confidence: 99%