Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice

Rodrigues, Melissa Raboni Alves; Kanazawa, Luiz Kae Sales; Neves, Thiago Louback Machado das; Silva, Carla Francielle da; Horst, Heros; Pizzolatti, Moacir Geraldo; Santos, Adair R.S.; Baggio, Cristiane Hatsuko; Werner, Maria Fernanda de Paula

doi:10.1016/j.jep.2011.11.042

Cited by 127 publications

(87 citation statements)

References 41 publications

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“…A mixture of these triterpenes was reported to be the possibly responsible for the antinociceptive activity of Bouchea fluminensis (Verbenaceae) determined by using the hot plate and writhing tests in mice (Costa et al, 2003). A mixture of ursolic acid/oleanolic acid was isolated from the active hexane fraction of Salvia officinalis and tested at 30 mg/kg, p.o., which inhibited (50%) the inflammatory phase of formalin test and the nociception and mechanical allodynia induced by cinnamaldehyde, an agonist of TRPA1 receptors (Alves-Rodrigues et al, 2012). Ursolic acid, among other active constituents, has been identified in species from Cestrum genus like C. auriculatum, C. hediundinum, and C. laurifolium (Kawano et al, 2009) and in Aristotelia chilensis (Muñ oz et al, 2011), which are used to alleviate headache, fever and rheumatism.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception

Martı́nez

González-Trujano

Chávez

et al. 2012

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception

Martı́nez

González-Trujano

Chávez

et al. 2012

Journal of Ethnopharmacology

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“…Currently, many reports are using S. officinalis (L.) to analyze its pharmacological activity and studies have shown its potential as anti-inflammatory (Rodrigues et al 2012), antimicrobial (Garcia et al 2012), hypoglycemiant (Shafiee-Nick et al 2012), anti-diabetic (Christensen et al 2010), antioxidant (Generalic et al 2012), to prevent neurodegenerative disease (Takano et al 2011) and antitumor activity (Al-Barazanjy et al 2013, Akaberi et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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Salvia offi cinalis (Lamiaceae) has been used in south of Brazil as a diary homemade, in food condiment and tea-beverage used for the treatment of several disorders. The objective of this study was to characterize chemical compounds in the hydroalcoholic (ExtHS) and aqueous (ExtAS) extract from Salvia offi cinalis (L.) by gas chromatography-mass spectrometry (GC-MS) and by high-resolution electrospray ionization mass spectrometry (ESI-QTOF MS/MS), evaluate in vitro ability to scavenge the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ), catalase (CAT-like) and superoxide dismutase (SOD-like) activity, moreover cytotoxic by MTT assay, alterations on cell morphology by giemsa and apoptotic-induced mechanism for annexin V/propidium iodide. Chemical identifi cation sage extracts revealed the presence of acids and phenolic compounds. In vitro antioxidant analysis for both extracts indicated promising activities. The cytotoxic assays using tumor (Hep-2, HeLa, A-549, HT-29 and A-375) and in non-tumor (HEK-293 and MRC-5), showed selectivity for tumor cell lines. Immunocytochemistry presenting a majority of tumor cells at late stages of the apoptotic process and necrosis. Given the results presented here, Brazilian Salvia offi cinalis (L.) used as condiment and tea, may protect the body against some disease, in particularly those where oxidative stress is involved, like neurodegenerative disorders, infl ammation and cancer.

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“…These results provide the pharmacological base for medicinal use of SO in treatment of gut disorders, such as diarrhea and abdominal colic. In another study, the hydroalcoholic extract of SO (10, 30 and 100 mg/ kg) decreased the number of abdominal constrictions that induced by acetic acid in female Swiss mice [15]. The results of a current study showed that Salvigenin, one of the active flavonoids existing in SO, can reduce the number of abdominal contractions at doses of 50 and 100 mg/kg.…”

Section: Muscle Relaxantmentioning

confidence: 50%

“…These effects were accompanied by inhibition of inflammation using the cotton pellet granuloma and carrageenan-induced paw edema in rats. The anti-inflammatory action of SO may be related to manool, carnosol, and ursolic acid which are main terpenes/terpenoids of the plant [14,15]. It has been reported that anti-inflammatory effect of ursolic acid is twofold more potent than that of indomethacin [16].…”

Section: Neurobiological Effects Analgesic and Anti-inflammatory Effectsmentioning

confidence: 99%

“…One such plant is Salvia officinalis L. (SO) which has several medical effects including antioxidant, antibacterial, fungistatic, antimutagenic, hypolipidaemic, gastroprotective and anti-Helicobacter pylori [4][5][6]. In Iranian traditional medicine, it is used for treating diarrhea, colic, dyspepsia, asthma, bronchosis, catarrh, cough and depression.…”

Section: Introductionmentioning

confidence: 99%

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Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease

Hasanein¹,

Sharifi²,

Emamjomeh³

2017

Med chem

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Salvia is the largest genus of the Lamiaceae family including about 100 species. Salvia officinalis L. (SO) is one of the most appreciated herbs for richness of the essential oil content and its numerous biologically active compounds. SO has been used in herbal medicine for many centuries. In Islamic literature, it is considered as one of the greatest forms of healing medicine. The leaves of the plant have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, anticancer, astringent, eupeptic and antihydrotic effects. Recently, this plant has been focused for its application in traditional medicine as well as to find new neurobiological properties. In this review, the up-todate information on the neurobiological effects of SO on the central nervous system will be reviewed. These include analgesic, memory enhancing, neuroprotective, anticonvulsant, anti-addictive, sedative, anxiolytic, and skeletal muscle relaxant effects. Furthermore, chemical compounds responsible for these effects and the clinical studies on this plant are presented and discussed.

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Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice

Cited by 127 publications

References 41 publications

Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception

Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease

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