Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves

Leitão, Maicon Matos; Silva-Filho, Saulo Euclides; Arena, Arielle Cristina; Vieira, Silvia Cristina Heredia; Cardoso, Cláudia Andréa Lima; Kassuya, Cândida Aparecida Leite

doi:10.1016/j.jep.2022.116018

Cited by 2 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, it has been reported that the majority of S. officinale's anti-inflammatory properties are due to the presence of polyphenols that selectively inhibit COX-2 and triterpenes that inhibit various stages of inflammation, including histamine release, cyclooxygenase (COX) and lipoxygenase (LOX) activity, and nitric oxide production. 11 Symphytum officinale, a plant with local anesthetic properties, activates endogenous opioid-dependent analgesic pathways through iontophoresis with direct current, enhancing joint function and motion. This technique also improves epidermal blood flow, enhancing local metabolism and blood supply.…”

Section: Iii) Cadencementioning

confidence: 99%

Evaluation Of Novel Iontophoretic Gel Containing Symphytum Officinale On Knee Osteoarthritic Patients

Sharmaa,

Tonkb,

Malik

et al. 2024

jaz

View full text Add to dashboard Cite

Introduction: One of the most prevalent disorders causing pain in the musculoskeletal system and eventual disability is osteoarthritis (OA). The concurrent use of pharmaceutical and non-pharmacological therapies is an essential component of the therapy. The purpose of this study was to assess the efficacy of iontophoresis therapy in patients with osteoarthritis (OA) of the knee joints using a newly formulated Gel containing symphytum officinale. Material and Methods:The study included 126 patients with Knee osteoarthritis treated at the Outpatient department at Delhi Pharmaceutical Sciences & Research University, New Delhi. Three groups were randomly selected: group I (n = 42), received iontophoresis with newly developed Gel containing symphytum officinale treatment was applied followed by exercise protocol, group II (n = 42) received iontophoresis with Indomethacin gel was applied followed by exercise protocol , and group III (n = 42) received placebo treatment with knee exercise protocol only. The Visual analog scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), Pittsburg sleep quality index (PSQI) & Walking cadence were used for the clinical evaluation of the patients. Results: Patients treated with a new gel containing symphytum officinale showed significant improvement in all assessed parameters compared to those treated with Indomethacin gel and placebo. Conclusions: The most favorable iontophoresis resulted from the introduction of a new gel containing symphytum officinale, followed by an exercise protocol.

show abstract

Section: Iii) Cadencementioning

confidence: 99%

Evaluation Of Novel Iontophoretic Gel Containing Symphytum Officinale On Knee Osteoarthritic Patients

Sharmaa,

Tonkb,

Malik

et al. 2024

jaz

View full text Add to dashboard Cite

show abstract

“…The ion trap mass spectrometer is a widely used instrument in various fields, such as food safety, − environmental protection, − aerospace engineering, − medical pharmaceuticals, − proteomics, − and metabolite analysis. − Its high efficiency, accuracy, and fast response make it highly favored. In the 1950s, Paul and Steinwedel developed a new type of magnet-free mass spectrometer, which laid the foundation for the development of ion trap mass spectrometers.…”

Section: Introductionmentioning

confidence: 99%

Fourier Transform Ion Trap Mass Analysis by Deciphering Ion Ejection Signals in the Frequency Domain

Yan,

Xu,

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

Mass analysis in an ion trap is conventionally realized through time domain analysis of the ejected ion current collected from an electron multiplier (EM), in which the ion ejection time is found to have a correlation with the mass-to-charge (m/z) ratio of the ion. In this study, we investigated a new method for mass analysis by examining ion ejection signals in the frequency domain. Theoretical analysis and ion trajectory simulations show that ions of the same m/z ratio are ejected from an ion trap at regular intervals, producing a periodic pulsed signal on the EM. The period of this pulsed ejection signal is directly linked to the m/z values of the ions. To realize this method experimentally, a broadband preamplifier was built and integrated on a miniature ion trap mass spectrometer (the "Brick" series from Nier Inc.) to capture this pulsed ion ejection signal collected from the EM. Experimental results were in good agreement with theoretical and simulation analyses. This method has the potential to improve the mass resolution of an ion trap mass analyzer. As a proof-of-concept demonstration, a peak width of 0.1 Da at a m/z value of 281 was achieved in experiments.

show abstract

Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves

Cited by 2 publications

References 48 publications

Evaluation Of Novel Iontophoretic Gel Containing Symphytum Officinale On Knee Osteoarthritic Patients

Evaluation Of Novel Iontophoretic Gel Containing Symphytum Officinale On Knee Osteoarthritic Patients

Fourier Transform Ion Trap Mass Analysis by Deciphering Ion Ejection Signals in the Frequency Domain

Contact Info

Product

Resources

About