Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus

Choi, Jongwon; Lee, Kyung‐Tae; Ha, Joohun; Yun, Seiyoung; Ko, Chang-Duk; Jung, Hyun‐Ju; Park, Hee-Juhn

doi:10.1248/bpb.26.1436

Cited by 88 publications

(67 citation statements)

References 22 publications

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“…4,19,20) Despite the absence of experimental studies concerning the analgesic properties of R. rosaefolius, other plants of the Rubus genus have exhibited important antinociceptive effects in mice. 6,12) Table 1 shows that the hydroalcoholic extract and any fractions caused a pronounced effect when analysed against writhing model in mice. As can been observed, the HE as well as the hexane, dichloromethane, ethyl acetate and butanolic fractions, caused activity, with MI values of 97.9, 93.4, 88.0, 93.8 and 51.4%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…They were identified on the basis of their spectral data as 28-methoxytormentic acid (1), tormentic acid (2) (Fig. 1) stigmasterol (3), campesterol (4), b-sitosterol (5) and its glycoside (6).…”

Section: Plant Materialsmentioning

confidence: 99%

“…[2][3][4] Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity. [5][6][7] Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives.…”

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confidence: 99%

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Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

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Rosaceae consists of a large family of plants, represented by fruits such as plums, cherries, damson plums, quinces, strawberries, pears and peaches.1) The plants to the genus Rubus, have been traditionally used to treat different diseases, particularly diabetes.2-4) Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity.5-7) Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives. 8,9,11) Recently, we have shown that another species, R. imperialis, presents hypoglycaemic, cytotoxic and antinociceptive actions. 9,[11][12][13] The main isolated active compound, named niga-ichigoside F1, showed marked antinociception and its mechanism of action appears to be related to the dopaminergic, cholinergic, glutamatergic, and tachykininergic and oxinitrergic systems. 14)Rubus rosaefolius, popularly known as "amora-do-mato" or "amora-vermelha" in Brazil, is a shrub measuring between 4 and 5 m, and is well distributed in the South of Brazil. 1,15) The current study extends our previous work on the biological properties of the Rubus species, and describes its phytochemical analysis and in vivo antinociceptive activity against two pain models in mice (writhing and formalin tests) of the extract, fractions and a pure compound isolated from the aerial parts of R. rosaefolius. Phytochemical Analysis Air-dried material from R. rosaefolius (700 g) was cut into small pieces and macerated with methanol at room temperature for 7 d. After filtration, the solvent was removed by rotatory evaporation under reduced pressure, yielding the respective methanolic extract (ME). Parallel to this, a hydroalcoholic extract (HE) was prepared through maceration of 100 g of plant with an ethanol-water (50 : 50) mixture and stored for use in the pharmacological test. The methanolic extract (35 g), were then suspended in a MeOH : water mixture (9 : 1) and successively partitioned with n-hexane, dichlomethane, ethyl acetate and n-butanol, to provide the respective fractions. The hexane and dichloromethane fractions (7.4, 4.2 g) were chromatographed on silica gel column eluted with a hexane : acetone mixture with increasing polarity. Similar fractions, which showed a positive reaction with anisaldehyde sulfuric reagents, were combined and rechromatographed as in the The Rubus species has been used in folk medicine to treat several ailments, including infectious and dolorous diseases. In this work we evaluate the phytochemical and analgesic activity of hydroalcoholic extract (HE), some fractions (hexane, dichloromethane, ethyl acetate and butanolic), as well as a pure compound denoted as 28-methoxytormentic acid (1) obtained from aerial parts of R. rosaefolius. The compounds were isolated and identified by chromatographic and spect...

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Section: Resultsmentioning

confidence: 99%

Section: Plant Materialsmentioning

confidence: 99%

mentioning

confidence: 99%

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Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Indomethacin was used as a standard drug. 12) This study complied with current ethical regulations on animal research (National Research Council of U.S.A., 1996) and all animals used in the experiment received humane care.…”

Section: Methodsmentioning

confidence: 93%

Two New Triterpenoid Saponins Isolated from Polygala japonica

Wang

Gao

Zhu

et al. 2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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Polygala japonica HOUTT. (Polygalaceae) widely distributes in Asian, primarily in eastern China. It has long history of using P. japonica in traditional Chinese medicines for the treatment of various inflammatory disorders, such as acute tonsillitis, pharyngitis, myelitis and nephritis. 1) Our bioassay guided investigation of P. japonica has showed that the methanol (MeOH) extract have significant anti-inflammation effect against carrageenan-induced mouse paw edema, and the ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions from it are the main active fractions. Our efforts further extended to isolate and identify the bioactive compounds in these fractions, which will support the wide utility of P. japonica in traditional Chinese medicines. We have isolated and elucidated two new triterpenoid saponins (1, 2), along with four known triterpenoid saponins, 4) and tenuifolin (6). 5) The structures of the known compounds were elucidated by comparison of their physical and spectral data with literature values. We report herein the isolation and structure elucidation of two new triterpenoid glycosides as well as the anti-inflammatory activity using the carrageenan-induced mouse paw edema for all the isolated saponins ( Fig. 1).Saponin 1 was obtained as a white amorphous powder, and assigned a molecular formula of C 58 H 92 O 28 , as deduced from HR-ESI-MS and 13 C-NMR (Table 1) (d H 5.43, t-like). Additionally, the 13 C-NMR spectra displayed six methyl groups, five anomeric carbons, and two olefinic carbons. A detailed comparison between 1 and the reference data of medicagenic acid, 6) a major aglycone present in this plant, implied that 1 possessed of the aglycone of medicagenic acid.

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“…The writhing test is considered a non-specific model (e.g. anticholinergic and antihistaminic and other agents show activity in this assay), but it is frequently used for analgesic screening and involves local peritoneal receptors (cholinergic and histamine receptor) and acetylcholine and histamine mediators (Calixto et al, 2000;Choi et al, 2003). The acetic acid model is generally used to evaluate the action of peripheral drugs, acting indirectly by inducing the release of endogenous mediators, which stimulate nociceptive neurons that are sensitive to non-steroidal anti-inflammatory drugs and/ or opioids (Collier et al, 1968).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

Silva¹,

Esquibel²,

Alves³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Efeito antinociceptivo de Abarema cochliacarpos (B.A. Gomes) Barneby & J.w.Grimes (Mimosaceae)". No presente trabalho foram avaliados a atividade antinociceptiva e o perfil fitoquímico dos extratos aquosos e metanólico produzidos com a casca do caule de Abarema cochliacarpos, uma espécie de Mata Atlântica com diversas indicações populares. Todos os extratos apresentaram atividade analgésica quando avaliados pelo teste das contorções abdominais induzidas pelo ácido acético via intraperitonial, apresentando respostas superiores às drogas usadas como referência, bem como no modelo da dor induzida por capsaicina. A avaliação fitoquímica demonstrou a presença de saponinas, catequinas, taninos, fenóis e antraquinonas.Unitermos: Abarema cochliacarpos, Mimosaceae, atividade analgésica, plantas medicinais, perfil fitoquímico. ABSTRACT:In this study, we investigated the analgesic activity of crude aqueous and methanol extracts obtained from Abarema cochliacarpos bark in mice, and analyzed its phytochemical profile. All the extracts exhibited analgesic properties against the writhing test in mice, but the aqueous and methanol extracts were more active, and more potent than two known analgesic and anti-inflammatory drugs used as reference. They were also active against the capsaicin-model, but inactive when evaluated in the hot-plate test. Phytochemical studies revealed the presence of saponins, catechins, tannins, phenols and anthraquinones.

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Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus

Cited by 88 publications

References 22 publications

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Two New Triterpenoid Saponins Isolated from Polygala japonica

Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

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