2022
DOI: 10.1590/1678-7757-2002-0304
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Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain

Abstract: Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain * Nociceptive and inflammatory orofacial pain is highly prevalent in the population, which justifies the search for safer analgesics. There is increasing evidence of the analgesic and anxiolytic potential of Lavandula angustifolia essential oil (LAV EO), which may represent, when administered through inhalation, may represent a safer alternative for pain treatment. Objective: to evaluate whether … Show more

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Cited by 7 publications
(3 citation statements)
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“…Of course, the behavioral benefits of the performed treatments could be attributed to their previously described diminishing impact on primary skin lesions [ 25 ], but in this investigation, we focused on the mechanisms that simultaneously occur in the hippocampus, since it has been confirmed for the regulation of anxiety levels [ 26 ]. Although there are no literature data for this specific source of antioxidants ( Filipendula ulmaria ), this methodological approach was strongly supported by the findings that interventions involving the restoration of oxidative equilibrium by applying other antioxidant supplementation ( Lavandula angustifolia ) could simultaneously result in an antinociceptive and anxiolytic-like outcome [ 27 ]. Interestingly, HBO treatment has also shown its benefits in preconditioning post-traumatic stress disorder in rats [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Of course, the behavioral benefits of the performed treatments could be attributed to their previously described diminishing impact on primary skin lesions [ 25 ], but in this investigation, we focused on the mechanisms that simultaneously occur in the hippocampus, since it has been confirmed for the regulation of anxiety levels [ 26 ]. Although there are no literature data for this specific source of antioxidants ( Filipendula ulmaria ), this methodological approach was strongly supported by the findings that interventions involving the restoration of oxidative equilibrium by applying other antioxidant supplementation ( Lavandula angustifolia ) could simultaneously result in an antinociceptive and anxiolytic-like outcome [ 27 ]. Interestingly, HBO treatment has also shown its benefits in preconditioning post-traumatic stress disorder in rats [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Devido à sua complexidade química, é improvável que tenha ação em um único alvo farmacológico 7 . Para o efeito analgésico, há evidências de sua ação no processo de neurotransmissão gabaérgica, especialmente via receptores GABA A , aumentando sua atividade inibitória, sua ação no sistema colinérgico e sua ação em receptores opioides e canabinoides envolvidos no sistema de controle endógeno da dor [22][23][24] .…”
Section: Discussionunclassified
“…Due to its chemical complexity, it is unlikely to have action on a single pharmacological target 7 . For analgesic effect, there is evidence of its action on the gabaergic neurotransmission process, especially via GABA A receptors, increasing its inhibitory activity, its action on the cholinergic system, and its action on opioid and cannabinoid receptors involved in the endogenous pain control system [22][23][24] .…”
Section: Discussionmentioning
confidence: 99%