Antinociceptive and gastro-protective effect of the ethanolic extract of the flowering top of Anthocephalus Cadamba Roxb

Abstract

SUMMARYThe effect of alcoholic extract of Anthocephalus (A.) Cadamba Roxb. was evaluated in experimental models of pain and ulcer. Hot tail flick test, hot plate test and acetic acid induced writhing test were employed for evaluating the peripheral as well as central analgesic mechanism exerted by the extracts. Gastroprotective activity was examined by HCl and ethanol induced gastric damage test. Test group received crude extract 500 mg/kg showed maximum time needed for the response against thermal stimuli (6.26 ± 0.439 s) which is comparable to diclofenac sodium (6.56 ± 0.381 s) in hot tail flick method. These experimental results also followed the experimental results of hot plate test where crude extract 500 mg/kg showed maximum time needed for the response against thermal stimuli (4.74 ± 0.234 s) which is comparable to diclofenac sodium (5.58 ± 0.585 s). The crude extract at 500 and 250 mg/kg showed significant reduction in acetic acid induced writhing in mice with a maximum effect of 68.026% reduction at 500 mg/kg dose which is comparable to standard diclofenac sodium (79.93%). In gastroprotective study the extract of A. Cadamba (250 and 500 mg/kg) significantly inhibited ulceration induced by both HCl and ethanol dose dependently. Results of the study suggest that the extract possesses both analgesic and gastroprotective activity on mice.

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

“…At the same time, the extracts also exhibited a significant decrease in gastric volume, free acidity, pH, total acidity, ulcer inhibition, as well as ulcer index [ 94 ]. The gastro-protective efficacy of A. cadamba was investigated in an in vivo mice study showing the ethanolic extract of A. cadamba at two doses of 250 and 500 mg/kg substantially decreased ulceration caused by both HCl and ethanol-dependent doses [ 95 ]. Similarly, in another report, the defatted aqueous extract of the leaves of this plant showed substantial analgesic and anti-inflammatory activities at different doses at 50, 100, 300, and 500 mg/kg [ 96 , 97 ].…”