Antinociceptive and hypothermic evaluation of the leaf essential oil and isolated terpenoids from Eugenia uniflora L. (Brazilian Pitanga)

Amorim, Ana Carolina L.; Lima, Cleverton Kleiton Freitas de; Hovell, Ana Maria C.; Miranda, Ana Luísa P.; Rezende, Cláudia M.

doi:10.1016/j.phymed.2009.03.009

Cited by 104 publications

(68 citation statements)

References 20 publications

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“…Infusions and decoctions from Eugenia uniflora L Myrtaceae pitanga are used in Brazil as anti-diarrhoeal, diuretic, anti-rheumatic, anti-fever, anti-tussive, expectorant, digestive, carminative, and controlling blood pressure, cholesterol and uric acid, and in reducing weight 12 ; leaves are used in the preparation of teas and EO from leaves are used in the manufacture of shampoos, conditioners, soaps and body oils 20 .…”

Section: Introductionmentioning

confidence: 99%

<i>In vitro</i> Antibacterial and Chemical Properties of Essential Oils Including Native Plants from Brazil against Pathogenic and Resistant Bacteria

et al. 2015

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Section: Introductionmentioning

confidence: 99%

<i>In vitro</i> Antibacterial and Chemical Properties of Essential Oils Including Native Plants from Brazil against Pathogenic and Resistant Bacteria

et al. 2015

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“…These components are chemically derived from terpenes and their oxygenated derivatives (Solórzano-Santos & Miranda-Novales, 2012). EO possesses many pharmacological effects described, such as antioxidant (Victoria et al, 2012;Wang et al, 2013), antimicrobial (Singh et al, 2013;Stefanakis et al, 2013), and antinociceptive (Amorim et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

Castro

Victoria

Hartwig

et al. 2014

Pharmaceutical Biology

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Context: Psidium cattleianum Sabine (Myrtacea) is rich in vitamin C and phenolic compounds, including epicatechin and gallic acid as the main components. Objective: To evaluate the antifungal and antioxidant capacity in vitro of the essential oil of araçá (EOA). The acute toxicity of the EOA also was evaluated in mice. Materials and methods: The leaves of the P. cattleianum were extracted by steam distillation. The antioxidant capacity was evaluated by in vitro tests [1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric ion reducing antioxidant power (FRAP), linoleic acid oxidation, thiobarbituric acid reactive species (TBARS)], and ex vivo analysis [TBARS, d-aminulevunilate dehydratase (d-Ala-D) and catalase activity, non-protein thiols (NPSH), and ascorbic acid levels]. The toxicity was studied in mice by a single oral administration of EOA; and the antifungal activity was performed with five strains of fungi. Results: The EOA exhibited antioxidant activity in the FRAP assay and reduced lipid peroxidation in the cortex (I max ¼ 32.90 ± 2.62%), hippocampus (IC 50 ¼ 48.00 ± 3.00 mg/ml and I max ¼ 32.90 ± 2.62%), and cerebellum (I max ¼ 45.40 ± 14.04%) of mice. Acute administration of the EOA by the oral route did not cause toxicological effects in mice (LD 50 4500 mg/ml). The EOA also showed antifungal activity through of the determination minimum inhibitory concentration (MIC) values ranging from 41.67 ± 18.04 to 166.70 ± 72.17 mg/ml for tested strains. Conclusion:The results of present study indicate that EOA possess antioxidant properties, antifungal and not cause toxicity at tested doses.

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“…其中化合物 2 为新化合物, 依据该化合物的核磁数据, Gavagnin 小组提出它的结构如图 1 所示 , 与苍术酮 (atractylon, 4) [4] 和 1,2-dihydrotubipofuran (5)类似 [5] , 都是桉烷(eudesmane)倍半萜类天然产物; 但对应于化合物 2 的天然产物的绝对构型尚无法确定. 在 Gavagnin 小组的报道中, 他们没有为该天然产物命名; 但在随后 Miranda 小组对包含该天然产物的混合物的活性研究中 , 它被命名为 3-furanoeudesmene [6] .…”

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“…此外, 巴西的 Miranda 小组研究发现, 天然产物 3-furanoeudesmene 和苍术酮(4)的混合物经小鼠口服后, 表现出明显的生物活性效应: 小鼠体温降低, 延长了小鼠在热板(hot plate)试验中的潜伏时间, 而且明显抑制了乙酸诱导的腹缢现象 [6] ; 这表明 3-furanoeudesmene (2)和苍术酮(4)的混合物具有抗伤害和低体温的生物效 Figure 1 Structures of target natural product and the related natural analogs…”

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Asymmetric Total Synthesis of 3-Furanoeudesmene, A Metabolitefrom Antarctic Gorgonian and Determination of Its AbsoluteConfiguration

Yu¹,

Liu²

2015

Chin. J. Org. Chem.

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The first total synthesis of 3-furanoeudesmene, an eudesmane-type sesquiterpenoid, is reported herein. Starting from the commercially available (＋)-verbenone, the target molecule was achieved stereoselectively over eight steps, with ring closing metathesis and three-step synthesis of furan as the keypoints. The absolute configuration of 3-furanoeudesmene was determined by comparison of the optical rotation value of the synthetic sample with that of the natural product.

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Antinociceptive and hypothermic evaluation of the leaf essential oil and isolated terpenoids from Eugenia uniflora L. (Brazilian Pitanga)

Cited by 104 publications

References 20 publications

<i>In vitro</i> Antibacterial and Chemical Properties of Essential Oils Including Native Plants from Brazil against Pathogenic and Resistant Bacteria

<i>In vitro</i> Antibacterial and Chemical Properties of Essential Oils Including Native Plants from Brazil against Pathogenic and Resistant Bacteria

Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

Asymmetric Total Synthesis of 3-Furanoeudesmene, A Metabolitefrom Antarctic Gorgonian and Determination of Its AbsoluteConfiguration

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