Antinociceptive C<sub>19</sub>–diterpenoid alkaloids from the roots of <i>Aconitum nagarum</i>

Hu, Jiang; Li, Shi-Fu; Li, Qiang; Lv, Tao; Peng, Tianfeng; Yin, Sheng; Min, Ying

doi:10.1080/10286020.2022.2109148

Cited by 2 publications

(7 citation statements)

References 12 publications

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“…When ester groups are present at C-8 and C-14, they exhibit acute toxicity [8]. In the past five years, 70 new compounds were discovered, with 65 obtained from Aconitum and 5 from Delphinium [32,34,38,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. The compounds were further discussed according to the presence of oxygen-containing groups connected at C-3, C-6, or C-15 positions.…”

Section: C18-dasmentioning

confidence: 99%

“…Compounds 79-84 are new C19-DAs with a vaginatunine A fragment at C-18 [32,55]. Compounds 89-91 lack a common methoxy group in DAs at C-16; however, there is a double bond between C-15 and C-16 [45,46,51]. • Lycoctonine-type C19-DAs (114-153) Compounds 92-94 possess oxygen-containing groups at C-3, C-6, and C-15 [48,56,57].…”

Section: C18-dasmentioning

confidence: 99%

“…Episcopaline B (182), Pseudostapine C (89), Austroyunnanine B (91), and Episcopine A (180) significantly reduced acetic acidinduced abdominal contractions in mice in a dose-related manner, with the ID 50 values of 55.0, 60.3, 48.0, and 66.1 µmol/kg, respectively [45,[50][51][52]. Nagarumine C (176) demonstrated significant analgesic activity and inhibited acetic acid-induced writhing in mice at 76.0 µmol/kg [46].…”

Section: Analgesic Activitymentioning

confidence: 99%

“…Acoapetaludines D (45) and E (46) showed weak anti-Helicobacter pylori activity with minimum inhibitory concentrations (MICs) of 100 and 50 µg/mL, respectively [40]. Stylosines A (157) and B (158) exhibited antibacterial activity against Staphylococcus aureus with MIC of 2.00 and 32.00 µg/mL, respectively [74].…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…The plant sources are shown in Table 8, and detailed chemical structures are shown in Figure 8. Over the past five years, only seven members (176-182) have been classified as rearranged C19-DAs [46,52,64,73,78]. Compounds 176 and 182 are unique alkaloids with a rearranged six-membered B ring formed by the C-8 and C-10 linkage [46,50].…”

mentioning

confidence: 99%

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Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

Wang,

Xin,

Sun

et al. 2024

Molecules

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Terpenoid alkaloids are recognized as a class of compounds with limited numbers but potent biological activities, primarily derived from plants, with a minor proportion originating from animals and microorganisms. These alkaloids are synthesized from the same prenyl unit that forms the terpene skeleton, with the nitrogen atom introduced through β-aminoethanol, ethylamine, or methylamine, leading to a range of complex and diverse structures. Based on their skeleton type, they can be categorized into monoterpenes, sesquiterpenes, diterpenes, and triterpene alkaloids. To date, 289 natural terpenoid alkaloids, excluding triterpene alkaloids, have been identified in studies published between 2019 and 2024. These compounds demonstrate a spectrum of biological activities, including anti-inflammatory, antitumor, antibacterial, analgesic, and cardioprotective effects, making them promising candidates for further development. This review provides an overview of the sources, chemical structures, and biological activities of natural terpenoid alkaloids, serving as a reference for future research and applications in this area.

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