Antinociceptive curcuminoid, KMS4034, effects on inflammatory and neuropathic pain likely via modulating TRPV1 in mice

Lee, J.Y.; Shin, Teo Jeon; Choi, Jae Moon; Seo, Kwang-Suk; Kim, Hyun Jeong; Yoon, Tae‐Jong; Lee, Y.S.; Han, Hyo Jo; Chung, Hanshik; Oh, You Na; Jung, Sung Jun; Shin, Kye Jung

doi:10.1093/bja/aet176

Cited by 41 publications

(25 citation statements)

References 36 publications

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“…For example, systemic curcumin has been shown consistently to produce significant reductions in the second phase of formalin-induced nocifensive behaviors in animals indicating inhibition of central sensitization. [8][9][10] Curcumin has also shown efficacy in models of neuropathic pain. For example, using the streptozotocin model of diabetic neuropathy curcumin reduced thermal hyperalgesia as well as serum levels of the proinflammatory, pronociceptive cytokine tumor necrosis factor alpha (TNFα).…”

mentioning

confidence: 99%

Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision

Sahbaie

Sun

Liang³

et al. 2014

Anesthesia &Amp; Analgesia

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mentioning

confidence: 99%

Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision

Sahbaie

Sun

Liang³

et al. 2014

Anesthesia &Amp; Analgesia

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“…The CCI model was established in ICR mice as previously described (Lee et al ., 2013). Briefly, mice with mechanical thresholds more than 2.0 g were anesthetized using 3% isoflurane.…”

Section: Methodsmentioning

confidence: 99%

“…Immunohistochemical staining for phospho-ERK (Cell Signaling, Danvers, MA, USA) at the L4–L5 level of the spinal cord was performed as previously described (Lee et al ., 2013). Immunofluorescence staining using anti-GFAP (Abcam, Cambridge, MA, USA), anti-interleukin (IL)-10 (MBL, Woburn, MA, USA), and anti-tumour necrosis factor alpha (TNFα; Santa Cruz Biotechnology, Inc.) was carried out as described previously (Jiang et al ., 2012).…”

Section: Methodsmentioning

confidence: 99%

Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Chung¹,

Yoon

Kim

et al. 2017

Biomolecules & Therapeutics

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This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey’s test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4–L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.

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“…Withdrawal thresholds were determined before and 2 hours after incision, and before and 4 hours after carrageenan injection, and after intrathecal administration of curcumin (10,30, or 100 mg in rats subjected to incisional pain; and 30, 100, or 300 mg in animals subjected to inflammatory pain).…”

Section: Effects Of Curcumin On Postoperative and Inflammatory Painmentioning

confidence: 99%

“…www.anesth-pain-med.org a synthetic curcuminoid analog reduced both formalin-and thermally induced nociception and neuropathic pain [29,30].…”

mentioning

confidence: 99%

Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

Shin

Yoon

et al. 2018

Anesth Pain Med

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Antinociceptive curcuminoid, KMS4034, effects on inflammatory and neuropathic pain likely via modulating TRPV1 in mice

Abstract: KMS4034 may be an effective analgesic for various pain conditions.

Cited by 41 publications

References 36 publications

Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision

Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision

Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

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Antinociceptive curcuminoid, KMS4034, effects on inflammatory and neuropathic pain likely via modulating TRPV1 in mice

Abstract: KMS4034 may be an effective analgesic for various pain conditions.

Cited by 41 publications

References 36 publications

Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision

Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision

Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Differential expression of spinal &gamma;-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

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Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats