Antinociceptive effect of 7-methoxyflavone isolated fromZornia brasiliensis

Abstract

In this study, we investigated the antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID₅₀ = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity.

The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia

“…A similar response has been observed with the opioid agonist, morphine. Previously, it has been reported that 7-methoxyflavone (7MF) isolated from Zornia brasiliensis reduces abdominal constriction behavior, inhibits the neurogenic phase of the formalin pain response and decreases glutamateinduced nociception without affecting the thermal response latency in the hotplate test [36]. The inability of 7MF to modify hotplate latency may be ascribed to the use of lower doses (≤ 300 μmol/kg, i.p.)…”

Antitumor Properties of the Leaf Essential Oil of Zornia brasiliensis

“…In the second, the antinociceptive effect of 7-methoxyflavone, an isolated compound from Z. cf. brasiliensis, was demonstrated in murine models [8]. The aim of this study was to investigate the chemical composition and antitumor potential of the leaf essential oil of Z. brasiliensis, which are reported here for the first time.…”

“…Numerous biological properties have been reported for the plants belonging to this genus, including molluscicidal [3], spasmolytic [4], antibacterial [5], cytotoxic [6,7], and antinociceptive activities [8]. Zornia brasiliensis Vogel, popularly known as "urinária", "urinana", and "carrapicho", is a medicinal plant used in Brazilian northeast folk medicine as a diuretic and against venereal diseases.…”

Rapid Characterization of Triterpene Saponins from Zornia brasiliensis by HPLC-ESI-MS/MS

“…It is associated with the Amazon, Caatinga, Cerrado, and Atlantic Forest phytogeographic domains [16], but is found mainly in the Brazilian Northeast [17] and Venezuela [18]. Two pharmacological studies of this species have reported the antinociceptive activity of 7-methoxyflavone isolated from its aerial parts [19] and the antitumor activity of its essential oil [20]. A recent phytochemical study of the aerial parts of this species resulted in the identification of 14 compounds, including flavones, flavanones, isoflavonoids, pterocarpans, chalcones, and a novel glycosylated dihydrochalcone—and this chalcone showed cytotoxic activity against HL-60 leukemic cells [21].…”