2004
DOI: 10.1016/j.brainres.2004.07.066
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Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel α1 subunits in the dorsal horn of spinal cord in mice

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Cited by 69 publications
(51 citation statements)
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“…Among these two isoforms, Cav2.3e was the major isoform preferentially expressed in small-sized TRPV1-positive nociceptive neurons and was restricted to IB4-negative and trkA-positive neurons. These results suggest that the expression patterns of Cav2.3 isoforms in nociceptive DRG neurons are similar to those of TG neurons; the strong presence of Cav2.3e mRNA may correlate with the expression of the R-type Ca 2+ channel, which might play a critical role in pain transmission in DRG neurons [26].…”
Section: Discussionmentioning
confidence: 63%
“…Among these two isoforms, Cav2.3e was the major isoform preferentially expressed in small-sized TRPV1-positive nociceptive neurons and was restricted to IB4-negative and trkA-positive neurons. These results suggest that the expression patterns of Cav2.3 isoforms in nociceptive DRG neurons are similar to those of TG neurons; the strong presence of Cav2.3e mRNA may correlate with the expression of the R-type Ca 2+ channel, which might play a critical role in pain transmission in DRG neurons [26].…”
Section: Discussionmentioning
confidence: 63%
“…Murakami et al, 2004;Catterall et al, 2005bCatterall et al, , 2007Matthews et al, 2007 (For selectivity see Table 4. )…”
Section: Ca V 23 (Cacna1e) Splice Variantsmentioning
confidence: 99%
“…Colocalization studies show that terminals expressing P/Q-type channels largely do not contain substance P, whereas those terminals using N-type channels to trigger release contain substance P. 46 Taken together with data showing that -conotoxin GVIA inhibits the release of substance P, it appears that blockade of N-type channels in laminae I and II affects nociception particularly associated with substance P release (and likely also CGRP and glutamate that tend to colocalize with substance P containing terminals. 47 It should be noted parenthetically that, as N-type channels are localized on both excitatory and inhibitory terminals in the spinal cord (including some interneurons), their inhibition could have quite variable physiological consequences dependent upon the nature of the specific signaling pathways affected. Also, it remains unknown whether there are distinct subtypes of spinal N-type channels with unique biophysical properties that might be differentially affected by drugs acting via state-dependent mechanisms.…”
Section: Does Block Of N-type Channels In the Dorsal Horn Affect Mostmentioning
confidence: 99%