Antinociceptive effect of Er:YAG laser irradiation in the orofacial formalin test

Zeredo, Jorge L.; Sasaki, Katia M.; Takeuchi, Yoshinari; Toda, Kazuo

doi:10.1016/j.brainres.2004.11.010

Cited by 19 publications

(9 citation statements)

References 29 publications

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“…In humans, sufficient and insufficient effects of LLLT by either CO 2 (11,15,19) or diode laser (12,20) irradiation have been reported. In animals, although CO 2 lasers have been used for noxious stimulation (30), analgesic effects of other lasers with long wavelengths have been reported (13,31). To exclude invasive effects and to evaluate the beneficial effects of CO 2 laser irradiation, an appropriate irradiation distance between the tip of the laser fiber and the tissue surface had to be determined.…”

Section: Discussionmentioning

confidence: 99%

Different Therapeutic Effects of CO2 and Diode Laser Irradiation on Tooth Movement-Related Pain

et al. 2020

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Although orthodontic treatment is common, orthodontic force often induced pain. Low-level laser therapy (LLLT) has been investigated to improve therapeutic comfort. In dentistry, LLLT is mainly applied using two types of lasers, CO 2 and diode lasers, whose biological actions are thought to be associated with wavelength (CO 2 : 10,600 nm; diode: 808 nm). The analgesic effect of LLLT on orthodontic treatment-related pain is widely reported but inconsistent. This study aimed to (1) determine whether irradiation with a CO 2 or diode laser attenuates orthodontic treatment-related pain using the jaw-opening reflex model, (2) elucidate the optimal irradiation protocol for both lasers to obtain the maximal analgesic effect, (3) evaluate the effects of laser irradiation on other biological features [e.g., tooth movement, glial fibrillary acidic protein (GFAP) expression, and temperature alterations] and (4) investigate the mechanism underlying the analgesic effect of laser irradiation. In this animal model, orthodontic treatment-induced pain manifested as a significantly reduced the threshold for inducing the jaw-opening reflex on the orthodontically treated side compared with the contralateral side. GFAP expression in the bilateral trigeminal ganglia (TGs) was significantly increased by the application of orthodontic force. CO 2 laser irradiation of the orthodontically treated region significantly increased the threshold for inducing the jaw-opening reflex and the peripheral temperature. Similar reductions in jaw-opening reflex excitability were induced by surface anesthesia and thermal stimulation but not, the diode laser. Neither CO 2 nor diode laser irradiation altered GFAP expression in the TGs. Infiltration anesthesia also significantly increased the threshold for inducing the jaw-opening reflex on each anesthetized side. Irradiation (30 s) by either laser immediately after orthodontic force application (preirradiation) significantly decreased jaw-opening reflex excitability and GFAP expression in the bilateral TGs the next day. However, thermal stimulation immediately after orthodontic force application failed to alter jaw-opening reflex excitability the next day. Laser irradiation did not alter tooth movement; however, Tsuchiya et al.Beneficial Effects of CO 2 Laser an optimized irradiation protocol for aiding tooth movement is suggested. In conclusion, both CO 2 and diode lasers are able to prevent orthodontic treatment-related pain. Furthermore, the involvement of temperature alterations and surface anesthesia in the analgesic effect induced by CO 2 laser irradiation is suggested.

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Section: Discussionmentioning

confidence: 99%

Different Therapeutic Effects of CO2 and Diode Laser Irradiation on Tooth Movement-Related Pain

et al. 2020

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“…Kasai et al [45] reported an inhibitory effect of PBMT on impulse conduction within a peripheral nerve, and it has been shown that PBMT suppressed the production of substances associated with pain, such as histamine or bradykinin [46]. Moreover, the secretion of inflammatory cytokines is suppressed by PBMT [47,48], and Zeredo et al [49] showed that PBMT has a tonic antinociceptive effect on inflammatory pain even when applied prior to tissue injury. As for clinical research, Caldrin et al showed that interleukin-1β and tumor necrosis factor-α levels were significantly lower in the group that underwent PBMT combined with SRP than in the SRP alone group [50].…”

Section: Plos Onementioning

confidence: 99%

Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: A systematic review and meta-analysis

et al. 2020

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Adjunctive use of laser devices as high reactive-level laser/light therapy (HLLT) or photobiomodulation therapy (PBMT) for periodontal therapy is known to be more effective on suppressing pain than conventional therapy, however, there are no systematic reviews addressed its effectiveness. This systematic review and meta-analysis aim to investigate the following clinical question (CQ): does adjunctive use of lasers with conventional therapy suppress the pain associated with periodontal treatment? A systematic and extensive literature search was performed to summarize the currently available knowledge to answer the CQ using the PubMed, Cochrane Library, and Web of Science databases for randomized controlled trials (RCTs) conducted before June 2020. Bias risk was assessed using the Cochrane tool for the risk of bias evaluation. A meta-analysis was performed on quantitative evaluation of pain control based on patient-reported outcomes. After an independent screening of 165 initial records, ten RCTs were included. Six of them focused on surgical procedures and the others on non-surgical periodontal pocket therapy. The protocols of HLLT, PBMT, and combination with HLLT and PBMT were employed in five, four and one RCTs, respectively. Following the assessment of bias risk, it is revealed that all RCTs had methodological weaknesses regarding the blinding of key personnel, although other bias risk factors were not evident. Meta-analysis showed that HLLT using erbium lasers significantly reduced the patient-reported pain immediately after treatment (two RCTs, p < 0.0001), while PBMT using diode lasers significantly reduced pain 2-7 days after treatment (two RCTs, p < 0.0001 to p = 0.03). The presented systematic review and meta-analysis suggest that the alternative use of HLLT using erbium lasers to conventional instrumentation can significantly suppress postoperative pain and that intraoperative or postoperative PBMT using diode lasers combined with periodontal surgery can significantly reduce postoperative pain. However, the evidence is still insufficient and more well-designed RCTs are required.

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“…Currently, the alternative therapies reported to be effective in OA include acupuncture technique, electric nerve stimulation, short wave, ultrasound, laser and static magnets . Among them, low level laser therapy (LLLT) has shown analgesic and anti‐inflammatory effects in vitro , and in vivo experimental models . Static magnetic field (SMF) therapy also has been reported to reduce inflammation and edema formation .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Irradiation of Magnetic Infrared Laser on Osteoarthritis Rat Model

Moon

Kwon

Woo

et al. 2014

Photochem & Photobiology

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Osteoarthritis (OA) is a degenerative joint disease caused by articular cartilage loss. Many complementary and alternative medicines for OA have been reported so far, but the effectiveness is controversial. Previously, we have shown anti-inflammatory effects of low level laser therapy with static magnetic field, magnetic infrared laser (MIL), in various animal models. Therefore, the beneficial effects were examined in OA rat model. Rats were divided by six groups; no treatment controls of sham and OA model, three MIL treatment groups of OA model at 6.65, 2.66 and 1.33 J cm(-2), and Diclofenac group of OA model with 2 mg kg(-1) diclofenac sodium. The OA control exhibited typical symptoms of OA, but 4-week MIL treatment improved the functional movement of knee joint with reduced edematous changes. In addition, cartilage GAGs were detected more in all MIL treatment groups than OA control. It suggests that 4-week MIL irradiation has dose-dependent anti-inflammatory and chondroprotective effects on OA. Histopathological analyses revealed that MIL treatment inhibits the cartilage degradation and enhances chondrocyte proliferation. The fact that MIL has an additional potential for the cartilage formation and no adverse effects can be regarded as great advantages for OA treatment. These suggest that MIL can be useful for OA treatment.

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Antinociceptive effect of Er:YAG laser irradiation in the orofacial formalin test

Cited by 19 publications

References 29 publications

Different Therapeutic Effects of CO2 and Diode Laser Irradiation on Tooth Movement-Related Pain

Different Therapeutic Effects of CO2 and Diode Laser Irradiation on Tooth Movement-Related Pain

Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: A systematic review and meta-analysis

Therapeutic Effect of Irradiation of Magnetic Infrared Laser on Osteoarthritis Rat Model

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