Antinociceptive Effect of Essential Oils and Their Constituents: an Update Review

Lenardão, Eder J.; Savegnago, Lucielli; Jacob, Raquel G.; Victoria, Francine Novack; Martinez, Débora M.

doi:10.5935/0103-5053.20150332

Cited by 35 publications

(29 citation statements)

References 11 publications

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“…The characteristics of the EO have made them highly valued in the industry for use in food, cosmetic, and pharmaceutical applications; these secondary metabolites have been related as potent antioxidants, anti-free radicals, and metal chelators, which also have anti-nociceptive, neuroprotective, anticonvulsant, and anti-inflammatory properties, reported in preclinical studies, which are characterized as possible sources for the development of new drugs [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

et al. 2020

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Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. It is an endemic tree known as “aceitillo”, and the antibacterial and antifungal activity of its essential oil has been verified; it also acts as an anti-inflammatory. All of these reported biological activities make the essential oil of B. morelensis a candidate to accelerate the wound-healing process. The objective was to determine the wound-healing properties of B. morelensis’ essential oil on a murine model. The essential oil was obtained by hydro-distillation, and the chemical analysis was performed by gas chromatography-mass spectrometry (GC-MS). In the murine model, wound-healing efficacy (WHE) and wound contraction (WC) were evaluated. Cytotoxic activity was evaluated in vitro using peritoneal macrophages from BALB/c mice. The results showed that 18 terpenoid-type compounds were identified in the essential oil. The essential oil had remarkable WHE regardless of the dose and accelerated WC and was not cytotoxic. In vitro tests with fibroblasts showed that cell viability was dose-dependent; by adding 1 mg/mL of essential oil (EO) to the culture medium, cell viability decreased below 80%, while, at doses of 0.1 and 0.01 mg/mL, it remained around 90%; thus, EO did not intervene in fibroblast proliferation, but it did influence fibroblast migration when wound-like was done in monolayer cultures. The results of this study demonstrated that the essential oil was a pro-wound-healing agent because it had good healing effectiveness with scars with good tensile strength and accelerated repair. The probable mechanism of action of the EO of B. morelensis, during the healing process, is the promotion of the migration of fibroblasts to the site of the wound, making them active in the production of collagen and promoting the remodeling of this collagen.

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Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

et al. 2020

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“…In this context, research groups have been dedicated to discover new molecules with analgesic potential and low toxicity. In fact, several pharmacological studies involving medicinal plants and their essential oils have been performed for this purpose [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)

et al. 2017

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Medicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p < 0.05). The same was observed in both phases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of KATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine.

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“…They show both sedative and analgesic properties, as well as anti-inflammatory and CNS depressor effects, as new studies suggest this kind of compound is able to pass through the blood brain barrier [16]. Plus, recent studies have demonstrated nepetalactone derivatives present anticonceptive activity as well as insect repellent ability [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Domino Reaction in the Asymmetric Synthesis of Cyclopentan[c]pyran Core of Iridoid Natural Products

et al. 2020

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The asymmetric synthesis of a compound with the cyclopentan[c]pyran core of iridoid natural products in four steps and 40% overall yield is reported. Our methodology includes a one-pot tandem domino reaction which provides a trisubstituted cyclopentane with five new completely determined stereocenters, which were determined through 2D homo and heteronuclear NMR and n.O.e. experiments on different compounds specially designed for this purpose, such as a dioxane obtained from a diol. Due to their pharmaceutical properties, including sedative, analgesic, anti-inflammatory, CNS depressor or anti-conceptive effects, this methodology to produce the abovementioned iridoid derivatives, is an interesting strategy in terms of new drug discovery as well as pharmaceutical development.

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Antinociceptive Effect of Essential Oils and Their Constituents: an Update Review

Cited by 35 publications

References 11 publications

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)

Multicomponent Domino Reaction in the Asymmetric Synthesis of Cyclopentan[c]pyran Core of Iridoid Natural Products

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