Antinociceptive effect of hydroalcoholic extract and isoflavone isolated from Polygala molluginifolia in mice: evidence for the involvement of opioid receptors and TRPV1 and TRPA1 channels

Nucci-Martins, Catharina; Nascimento, Leandro F.; Venzke, Dalila; Brethanha, Lizandra C.; Sako, Alysson V. F.; Oliveira, Aldo Sena de; Brighente, Inês Maria Costa; Micke, Gustavo Amadeu; Pizzolatti, Moacir Geraldo; Santos, Adair R.S.

doi:10.1016/j.phymed.2016.02.002

Cited by 16 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, Chalcones have been introduced as selective cyclooxygenase-2 inhibitors (52). Also, isoflavone isolated from Polygala molluginifolia had an antinociceptive effect on mice (53).…”

Section: Discussionmentioning

confidence: 96%

Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats

Parandin

Daroogari

2019

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually used to alleviate pain and Inflammation. The widespread use of NSAIDs has caused the risk and side effects of these drugs commonly increase. Objectives: This study aimed to examine the anti-inflammatory and antinociceptive activities of ethanolic extract of propolis (EEP) in male mice and rats. Methods: In this experimental study, EEP was prepared and administered in doses of 100, 200, and 400 mg/kg of body weight. The anti-inflammatory potential was assessed by inflammatory models of xylene-induced ear edema and cotton pellet granuloma tests, whereas the antinociceptive potential was assessed by formalin and acetic acid-induced writhing methods. Results: The EEP at doses of 100 (P < 0.05), 200 (P < 0.001) and 400 mg/kg (P < 0.001) significantly diminished the foundation of edema caused by xylene. A significant decrease was seen in granuloma weight in EEP at doses of 200 (P < 0.001) and 400 mg/kg (P < 0.001). The extract caused a significant decrease in licking time at first phase in EEP at 100 (P < 0.01), 200 (P < 0.001), and 400 mg/kg (P < 0.001). A significant decrease was observed (P < 0.001) in licking time at the second phase in EEP at doses of 100, 200, and 400 mg/kg. In the writhing model, a significant decrease was observed in the number of writhes in EEP at doses of 100 (P < 0.05), 200 (P < 0.001), and 400 mg/kg (P < 0.001). Conclusions: The findings of this research showed that the ethanolic extract of propolis has considerable anti-inflammatory and antinociceptive activities.

show abstract

Section: Discussionmentioning

confidence: 96%

Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats

Parandin

Daroogari

2019

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…2 Phenolic compounds (phenolic acids, flavonoids and other polyphenolics) are well known for their ability to inhibit pain perception as well as inflammatory processes. 27,28 Alkaloids present a valuable source of pharmaceuticals because they show a variety of biological activities. 29 Gelsemine and Bullatine A are alkaloids with established anti-nociceptive and anti-inflammatory activities respectively.…”

Section: Resultsmentioning

confidence: 99%

Preliminary Studies on the Anti-Inflammatory and Analgesic Effects of Methanol Leaf Extract of Ficus asperifolia Miq

Abdullahi¹,

Yaro²,

Nazifi³

2020

TJNPR

View full text Add to dashboard Cite

is used in the treatment of diabetes mellitus, hypertension, dysentery, diseases of the kidneys, urinary and respiratory tract infections. 7, 9 Previous studies conducted on Ficus asperifolia showed that it possesses gastroprotective, 10 uterotonic, 11 hypoglycaemic 12 and hypolipidaemic properties. 13 The leaves of the plant have been found to possess antioxidant activities 14 as well as ameliorative effects against testicular problems. 8 Essential oils obtained from Ficus asperifolia were found to possess antimicrobial properties 15 and according to Watcho et al., 16 the fruit extracts possess androgenic-like activities. However, there are relatively scarce reports on the antiinflammatory or analgesic properties of the plant despite its wide usage in ethno-medicine against inflammatory diseases and pain management. This study, therefore, was aimed at evaluating the antiinflammatory and analgesic activities of methanol leaf extract of Ficus asperifolia on mice and rats. Materials and Methods Drugs and chemicals The drugs and chemicals used for the studies include: Morphine sulphate

show abstract

“…This effect can be attributed, at least in part, to the large amounts of its two main compounds, rutin and 5,3’,4’-trihydroxy-6’’,6’’-dimethylpyrano [2’’,3’’:7,6] isoflavone, which affect the NF-κB pathway by inhibiting p65 phosphorylation and its translocation into the nucleus, similar to the effect observed with dexamethasone. The potential for the extract to inhibit mechanical and thermal hyperalgesia (heat and cold) in postoperative pain in mice without causing sedation or locomotor dysfunction has been evidenced recently [ 35 ]. However, the precise mechanism is not completely known.…”

Section: Resultsmentioning

confidence: 99%

Solving the puzzle: what is behind our forefathers anti-inflammatory remedies?

Villanueva

Alonso‐Esteban

Villanueva

2017

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

Inflammation is a ubiquitous host response in charge of restoring normal tissue structure and function but is a double-edged sword, as the uncontrolled or excessive process can lead to the injury of host cells, chronic inflammation, chronic diseases, and also neoplastic transformation. Throughout history, a wide range of species has been claimed to have anti-inflammatory effects worldwide. Among them, Angelica sinensis, Tropaeolum majus, Castilleja tenuiflora, Biophytum umbraculum, to name just a few, have attracted the scientific and general public attention in the last years. Efforts have been made to assess their relevance through a scientific method. However, inflammation is a complex interdependent process, and phytomedicines are complex mixtures of compounds with multiple mechanisms of biological actions, which restricts systematic explanation. For this purpose, the omics techniques could prove extremely useful. They provide tools for interpreting and integrating results from both the classical medical tradition and modern science. As a result, the concept of network pharmacology applied to phytomedicines emerged. All of this is a step toward personalized therapy.

show abstract

Antinociceptive effect of hydroalcoholic extract and isoflavone isolated from Polygala molluginifolia in mice: evidence for the involvement of opioid receptors and TRPV1 and TRPA1 channels

Cited by 16 publications

References 37 publications

Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats

Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats

Preliminary Studies on the Anti-Inflammatory and Analgesic Effects of Methanol Leaf Extract of Ficus asperifolia Miq

Solving the puzzle: what is behind our forefathers anti-inflammatory remedies?

Contact Info

Product

Resources

About

Antinociceptive effect of hydroalcoholic extract and isoflavone isolated from Polygala molluginifolia in mice: evidence for the involvement of opioid receptors and TRPV1 and TRPA1 channels

Cited by 16 publications

References 37 publications

Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats

Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats

Preliminary Studies on the Anti-Inflammatory and Analgesic Effects of Methanol Leaf Extract of Ficus asperifolia Miq

Solving the puzzle: what is behind our forefathers&#146; anti-inflammatory remedies?

Contact Info

Product

Resources

About

Solving the puzzle: what is behind our forefathers anti-inflammatory remedies?