Antinociceptive Effect of Hydroxydihydrocarvone

Oliveira, Fernando de Sousa; Sousa, Damião Pergentino de; Almeida, Reinaldo Nóbrega de

doi:10.1248/bpb.31.588

Cited by 41 publications

(22 citation statements)

References 31 publications

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“…The second phase is characterized by inflammatory pain triggered by a combination of stimuli, including inflammation of the peripheral tissues and mechanisms of central sensitization [22] and results from the action of inflammatory mediators in peripheral tissues such as prostaglandins, serotonin, histamine and bradykinin. Moreover, it includes functional changes in neurons of the spinal dorsal horn that, in the long term, promote facilitation of synaptic transmission at the spinal level [23,24]. In this test, CcL showed a greater inhibition in the second phase, suggesting that the antinociceptive effect of that lectin is related to inflammatory pain.…”

Section: Discussionmentioning

confidence: 94%

Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides

Vanderlei

Patoilo

Lima

et al. 2010

International Immunopharmacology

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The search for new compounds for controlling pain and inflammation, with minimal side effects has focused on marine algae. The aim of this work was to investigate the effect of the purified lectin from the green marine alga Caulerpa cupressoides (CcL) in classical models of nociception and inflammation. Male Swiss mice received i.v. CcL 30 min prior to receiving 0.8% acetic acid (10 ml/kg; i.p); 1% formalin (20 microl; s.c.) or were subjected to thermal stimuli. We observed that CcL (3, 9 or 27 mg/kg) significantly reduced the number of writhes induced by acetic acid by 37.2%; 53.5% and 86.0%, respectively. CcL (27 mg/kg) also reduced the second phase of the formalin test. However, CcL (27 mg/kg) did not present significant antinociceptive effects in the hot plate test, when compared to morphine, suggesting that its antinociceptive action occurs predominantly through a peripheral mechanism. The antinociceptive effects were abolished when CcL was pre-incubated with mucin (20mg/kg; i.v.). When CcL (9 mg/kg) was administered i.v. in Wistar rats 30 min before carrageenan administration, neutrophil counts were reduced by 65.9%. CcL also inhibited paw edema in all time intervals, especially at the third hour. Finally, CcL (9 mg/kg) administered i.v. in mice did not cause hepatic or renal alterations and did not affect body mass or macroscopy of the organs examined. In conclusion, CcL appears to have important antinociceptive and anti-inflammatory activities and could represent an important agent for future studies.

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Section: Discussionmentioning

confidence: 94%

Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides

Vanderlei

Patoilo

Lima

et al. 2010

International Immunopharmacology

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“…administration of ouabain (0.56 mg/kg) and morphine (10 mg/kg, i.p. ), and tested using the hot plate test [37]. …”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

Vasconcelos

Leite

Carneiro

et al. 2011

Mediators of Inflammation

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Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to modulate the immune response, little is known about the effect of this substance on the inflammatory process. The aim of this work was to study the effects triggered by ouabain on inflammation and nociceptive models. Ouabain produced a reduction in the mouse paw edema induced by carrageenan, compound 48/80 and zymosan. This anti-inflammatory potential might be related to the inhibition of prostaglandin E2, bradykinin, and mast-cell degranulation but not to histamine. Ouabain also modulated the inflammation induced by concanavalin A by inhibiting cell migration. Besides that, ouabain presented antinociceptive activity. Taken these data together, this work demonstrated, for the first time, that ouabain presented in vivo analgesic and anti-inflammatory effects.

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“…The second phase occurs between 15 and 30 minutes after injection of formalin, which inflammatory mediators formed in peripheral tissues such as prostaglandins, serotonin, histamine and bradykinin induce functional changes in the dorsal horn neurons that, over time, promote the easy transmission in the spinal level. This evidence suggests that peripheral inflammation process is involved in the second stage 54 . The 3BPA in the tested doses significantly reduced the lick time compared to the control group in the inflammatory phase of the formalin test.…”

Section: Pharmaceutical Biotechnologymentioning

confidence: 71%

Study of anti-inflammatory and analgesic properties of 3-benzoyl-propionic acid

Ávila¹,

Sena²,

Machi³

et al. 2017

PRMJ

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Summary Inflammation is an attempt by the body to remove noxious stimuli and initiate thus a cascade of responses in order to promote healing. There are a variety of inflammatory mechanisms involved in infections, chronic diseases and other tissue damage. Understanding these mechanisms and the search for new anti-inflammatory drugs with greater specificity and fewer side effects, underlying the development and improvement of new protocols and standardization of experimental inflammatory models to understand better these issues. The aim of this study was to evaluate the anti-inflammatory and analgesic activity of 3-benzoyl-propionic acid (3BPA) and its potential toxicological effect. To test the 3BPA as new anti-inflammatory and analgesic drug, the use carrageenan air pouch model 1% by in vitro model of cell culture to test genocytotoxicity. In the in vitro model the 3BPA presented low level of genotoxic and low cytotoxicity risk, shown by comet assay and no damage to the plasma membrane by hemolytic test erythrocytes. In the study of anti-inflammatory activity in vivo by the air pouch method were conducted nitrite dose trials, PGE 2 levels and cell migration. To verify analgesic effects of 3BPA drug in vivo tests of abdominal contortions induced by acetic acid and formalin were performed. Regard to the anti-inflammatory activity, 3BPA showed intense activity shown in marked reduction of cell migration and levels of NO, with large populations of neutrophils and reduction of PGE 2 values at a dose of 0.5mg/kg. In studies of antinociceptive activity, 3BPA reduced the number of writhes and the time lick the neurogenic and inflammatory phases of the formalin test. The results of this study also advanced substantially with respect to anti-inflammatory and analgesic properties of 3BPA by providing evidence of their likely mechanism of action, through the evaluation of antinociceptive activity, as well as the anti-inflammatory activity in vitro and in vivo, where the 3BPA showed no genotoxic effect.

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Antinociceptive Effect of Hydroxydihydrocarvone

Cited by 41 publications

References 31 publications

Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides

Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

Study of anti-inflammatory and analgesic properties of 3-benzoyl-propionic acid

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