Antinociceptive effect of linear polarized 0.6 to 1.6 um irradiation of lumbar sympathetic ganglia in chronic constriction injury rats

Abstract

Abstract-Linear polarized near-infrared light created with linear polarized near-infrared light therapy equipment (Super Lizer TM HA-550, Tokyo Iken Co, Ltd, Tokyo, Japan) has been used for the treatment of various painful disorders in Japan. Irradiation near the stellate ganglion with a Super Lizer (ISGL) is an especially notable therapeutic method used with stellate ganglion block (SGB) or substitutes for SGB. ISGL is a safe, simple, well-tolerated, and effective treatment. We examined the effects of irradiation with a Super Lizer applied to an area near the lumbar sympathetic ganglia on the ligated side in a chronic constriction injury (CCI) model, which is believed to be an animal model of complex regional pain syndrome (CRPS). Rats showing thermal hyperalgesia in a radiant heat test 1 wk postoperatively were used in Experiments 1 and 2: (1) Thermal hyperalgesia of irradiation group (n = 11) was less than that of the control or nonirradiation (n = 11) group at 1, 3, and 8 h after irradiation; however, the effect disappeared 12 h after irradiation. (2) Daily irradiation (n = 16) and 1 wk (n = 14) from 7 days after nerve ligation significantly shortened the interval from thermal hyperalgesia until recovery. Rats showing mechanical hyperalgesia in the von Frey hair test 1 wk postoperatively were used in Experiment 3: 1 wk irradiation beginning 7 days after nerve ligation (n = 9) did not promote the recovery from mechanical hyperalgesia. We speculate that repeated ISGL may be more effective than a single ISGL in alleviating pain in CRPS patients. We cannot explain the discrepancy between the results obtained in Experiments 2 and 3. We believe the results of this study are relevant to the effect of ISGL for patients with upper-limb CRPS: irradiation near the lumbar sympathetic ganglia of the rat is effective for thermal but not mechanical pain in CCI.

Effects of Linear-Polarized Near-Infrared Light Irradiation on Chronic Pain

“…Indeed, Kashima et al [3] observed changes in sensory and pain perception thresholds in the trigeminal region, and Muneshige et al [14] observed antinociceptive effects in vivo in rats after the treatment of LPNIR.…”

Analgesia for Sheep in Commercial Production: Where to Next?

“…Polarized light applied to the skin over the trigeminal nerve (on the cheek) reduced pain sensitivity both on the treated skin and on the forearm [45], suggesting that the effects of photomodulation of one nerve can be transferred to other nearby neural pathways. Muneshige et al [61] used polarized near-infrared light (wavelength range 600-1600 nm) allied to the lumbar area of rats (n = 11) in a sciatic nerve ligation model. A single treatment of 60 s irradiation significantly reduced hyperalgesia for at least 8 h post-treatment, while daily application, beginning one week after nerve ligation significantly reduced hyperalgesia for up to one month (after which the non-irradiated controls were returning to normal.…”

Effect of high-intensity pulse irradiation with linear polarized near-infrared rays on muscle tone in patients with cerebrovascular disease: a randomized controlled trial

“…The equipment required for LPNR irradiation is a phototherapy device that emits infrared rays at deep penetrating wavelengths (600–1,600 nm) 3 , 4 , 5 , 6 , 7 ) . LPNR irradiation is commonly used in various therapeutic scenarios because of its noninvasiveness, safety, and simplicity 2 , 4 , 5 , 6 , 8 , 9 , 10 ) .…”