Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Mannan, Md. Abdul; Khatun, Ambia; Khan, Md. Farhad Hossen

doi:10.1186/s12906-017-1565-y

Cited by 20 publications

(16 citation statements)

References 55 publications

(58 reference statements)

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“…Acetic acid-induced abdominal writhing response, hot-plate test, and formalin-induced licking response are commonly useful models for evaluation of antinociceptive drugs [ 30 ]. The first model is chemical induced nociception for detecting both central and peripheral analgesics.…”

Section: Discussionmentioning

confidence: 99%

Evaluation on Analgesic and Anti‐Inflammatory Activities of Total Flavonoids from Juniperus sabina

Zhao

Maitituersun

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The leaves of Juniperus sabina (Cupressaceae) are used in traditional Uygur medicine for the treatment of rheumatism and arthritic pain. This study aimed to investigate the analgesic and anti-inflammatory effects of total flavonoids from leaves of Juniperus sabina (JSTF) on rodents. The anti-inflammatory activity was investigated using the carrageenan, egg albumin, or histamine-induced rat paw edema as well as xylene-induced ear edema, capillary permeability, and cotton pellet granuloma while the antinociceptive activity was evaluated using the mouse writhing, formalin, and hot-plate tests. JSTF (125, 250, 500 mg/kg) significantly inhibited xylene-induced ear edema in mice (inhibition ratio as 16.22%, 40.67%, and 51.78%, respectively) and also significantly ameliorated acetic acid increased vascular permeability in mice (inhibition ratio as 11.63%, 32.56%, and 53.49%, respectively). JSTF (250 and 500 mg/kg) gave significant reduction of carrageenin-induced paw oedema at the interval of 1 h and 5 h. Administration of JSTF (500 mg/kg) caused a significant anti-inflammatory effect against oedema induced by egg albumin or histamine at the interval of 0.5 h and 4 h, and both which induced the paw oedema were also inhibited by JSTF (250 mg/kg) at a point in 1, 2, or 3 h after the inflammation. Furthermore, JSTF (125, 250, and 500 mg/kg) produced time-course increase in pain threshold in hot-plate test also. JSTF produced concentration-dependent inhibition on cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LO) activities in vitro, and their IC50 values were 31.92 and 129.26 μg/mL, respectively. Moreover, JSTF significantly caused a significant dose-dependent inhibition on acetic acid induced writhing response in mice (inhibition ratio as 23.27%, 36.91%, and 50.76%, respectively). JSTF also significantly ameliorated formalin-induced pain in mice in the late phase on dose-dependent way. These results confirms the clinical use of J. sabina for treatment of rheumatoid arthritis in ethnomedicine, and its effective mechanism will be further studied in the future.

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Section: Discussionmentioning

confidence: 99%

Evaluation on Analgesic and Anti‐Inflammatory Activities of Total Flavonoids from Juniperus sabina

Zhao

Maitituersun

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Peripheral nociception was investigated by acetic acid induced writhing test. Acetic acid triggers the pain through release of histamine, serotonin, bradykinins, prostaglandins (PGs) and substance P [43]. The results of writhing test suggest a peripheral effect of PVFO as analgesic activity in tail flick and hot plate tests was delayed.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of Phaseolus vulgaris L. Fixed Oil in Rodents

Salma

Baig

Hasan

et al. 2018

J. Basic Appl. Sci.

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The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked with anticancer, antihyperlipidemic, hypoglycemic and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetyl salicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg dose demonstrated analgesic and anti-inflammatory activities but in hot plate results were unreliable as here significant activity started after 90 minutes. For toxicity test 5ml/kg dose was administered orally in mice and no toxicity symptoms were observed. It is therefore concluded that PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.

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“…Based on its ability to attenuate both the acetic acid- and thermal-induced nociceptive responses, PECN is suggested to have a potential to inhibit nociceptive response at the peripheral and central levels [20–22]. This suggestion is based on previous reports that demonstrated ASA (a peripherally-acting analgesic) ability to attenuate only the acetic acid-induced nocieptive response [20] and MOR (a centrally-acting analgesic) potentials to inhibit both models of nociception [21, 23].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

Zakaria

Rahim

Sani

et al. 2019

BMC Complement Altern Med

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Background Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitioned to obtain petroleum ether extract of C. nutans (PECN), which was subjected to antinociceptive study with aims of establishing its antinociceptive potential and determining the role of opioid receptors and l –arginine / nitric oxide / cyclic-guanosine monophosphate ( l –arg / NO / cGMP) pathway in the observed antinociceptive activity. Methods The antinociceptive potential of orally administered PECN (100, 250, 500 mg/kg) was studied using the abdominal constriction-, hot plate- and formalin-induced paw licking-test in mice ( n = 6). The effect of PECN on locomotor activity was also evaluated using the rota rod assay. The role of opioid receptors was determined by pre-challenging 500 mg/kg PECN (p.o.) with antagonist of opioid receptor subtypes, namely β–funaltrexamine (β–FNA; 10 mg/kg; a μ-opioid antagonist), naltrindole (NALT; 1 mg/kg; a δ-opioid antagonist) or nor–binaltorphimine (nor–BNI; 1 mg/kg; a κ-opioid antagonist) followed by subjection to the abdominal constriction test. In addition, the role of l –arg / NO / cGMP pathway was determined by prechallenging 500 mg/kg PECN (p.o.) with l –arg (20 mg/kg; a NO precursor), 1H-[1, 2, 4] oxadiazolo [4,3-a]quinoxalin-1-one (ODQ; 2 mg/kg; a specific soluble guanylyl cyclase inhibitor), or the combinations thereof ( l –arg + ODQ) for 5 mins before subjection to the abdominal constriction test. PECN was also subjected to phytoconstituents analyses. Results PECN significantly ( p < 0.05) inhibited nociceptive effect in all models in a dose-dependent manner. The highest dose of PECN (500 mg/kg) also did not significantly ( p > 0.05) affect the locomotor activity of treated mice. The antinociceptive activity of PECN was significantly ( p < 0.05) inhibited by all antagonists of μ-, δ-, and κ-opioid receptors. In addition, the antinociceptive activity of PECN was significantly ( p < 0.05) reversed by l –arg, but insignificantly ( p > 0.05) affected by ODQ. HPLC analysis revealed the presence of at least cinnamic acid in PECN. Conclusion PECN exerted antinocicpetive activity at peripheral and central levels possibly via the activation of non-selective...

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Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Cited by 20 publications

References 55 publications

Evaluation on Analgesic and Anti‐Inflammatory Activities of Total Flavonoids from Juniperus sabina

Evaluation on Analgesic and Anti‐Inflammatory Activities of Total Flavonoids from Juniperus sabina

Analgesic and Anti-Inflammatory Effects of Phaseolus vulgaris L. Fixed Oil in Rodents

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

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