Antinociceptive effect of taurine and its inhibition by naxolone

Serrano, Juan Bautista Vivero; Serrano, M.I.; Guerrero, MCarmen; Ruiz, Rosa María Ávila; Polo, Juan

doi:10.1016/0306-3623(90)90833-8

Cited by 23 publications

(5 citation statements)

References 16 publications

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“…For example, systemic and intrathecal administration of taurine induced the antinociceptive effects to inhibit the intensity of caudally-directed biting, scratching, and paw licking behaviors by chemical agent and by the hot-plate test at acute pain tests in mouse [36, 37]. It has been reported that dietary supplementation with taurine suppresses hyperalgesia in streptozotocin-induced diabetic rats and autotomy behavior in genetically selected Sabra strain rats [38].…”

Section: Introductionmentioning

confidence: 99%

Activation of Glycine and Extrasynaptic GABA_AReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

et al. 2013

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The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) has been known for the processing and transmission of orofacial nociceptive information. Taurine, one of the most plentiful free amino-acids in humans, has proved to be involved in pain modulation. In this study, using whole-cell patch clamp technique, we investigated the direct membrane effects of taurine and the action mechanism behind taurine-mediated responses on the SG neurons of the Vc. Taurine showed non-desensitizing and repeatable membrane depolarizations and inward currents which remained in the presence of amino-acid receptors blocking cocktail (AARBC) with tetrodotoxin, indicating that taurine acts directly on the postsynaptic SG neurons. Further, application of taurine at different doses (10 μM to 3 mM) showed a concentration dependent depolarizations and inward currents with the EC50 of 84.3 μM and 723 μM, respectively. Taurine-mediated responses were partially blocked by picrotoxin (50 μM) and almost completely blocked by strychnine (2 μM), suggesting that taurine-mediated responses are via glycine receptor (GlyR) activation. In addition, taurine (1 mM) activated extrasynaptic GABAA receptor (GABAAR)-mediated currents. Taken together, our results indicate that taurine can be a target molecule for orofacial pain modulation through the activation of GlyRs and/or extrasynaptic GABAARs on the SG neurons.

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Section: Introductionmentioning

confidence: 99%

Activation of Glycine and Extrasynaptic GABA_AReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

et al. 2013

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“…A large number of studies suggest that in spinal cord taurine may act as inhibiting neurotransmitter, such interpretation also see the possibility of its involvement in the anti-epileptic action in spinal cord (Kurachi et al, 1985 andKudo et al, 1998). Besides this, anti-nociceptive effect in the spinal cord has also been observed, and this effect is inhibited by naloxane (Serrano et al, 1990). In addition to this, taurine selectively inhibits substances P induced biting and scratching behavior, known to hyperpolarize cell membrane and inhibits firing, when it is iontophoretically applied to neurons in the cat spinal cord.…”

Section: Introductionmentioning

confidence: 91%

“…In addition to above taurine showed to hyperpolarize cell membrane and inhibit firing when iontophoretically applied to spinal cord neurons (Curtis et al, 1974), this further supports taurine's claim of neurotransmitter or neuro-modulatory role in this region. Taurine has also exhibited anti-nociceptive effect in the spinal cord but this effect is inhibited by naloxane (Serrano et al, 1990), along with this taurine also inhibits substance P induced biting and scratching behavior (Smullin et al, 1990). In addition to above, this group further observed that in spinal cord taurine also inhibits nociceptive related writhing behavior produced by acetic acid in mice.…”

Section: Pharmalogical and Physiological Action Of Taurinementioning

confidence: 96%

Role of Taurine in Spinal Cord Injury

Gupta¹,

Seki

Yosida

2006

CNR

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Taurine is a sulfur amino acid. It is found endogenously in human and several others tissues. It is significantly in high concentration in mammals. Human body contains about 0.1% of body weight as taurine. It has a number of physiological and pharmacological actions. It is also used in the therapy of important organs dysfunctions. In spinal cord it has inhibitory effects; like antiepileptic and anti-nociceptive. Taurine also inhibits substance p induced biting and scratching behavior. In spinal cord injury elevated level of taurine has been observed. Higher level of taurine has been also recorded in SCI therapy using, known clinical agent methyl prednisolone (MP). The increased taurine concentration seems to be involved in protection and regeneration of tissues following injury. In SCI along with physical injury secondary activities also takes place which are complex in nature. Secondary activity includes vascular events and activation of neutrophils, resulting endothelial damage. Activated neutrophils; release a variety of inflammatory mediators such as myeloperoxidase (MPO), reactive oxygen species (ROS), and some others. It is believed that taurine exert its protective action through scavenging of ROS and down regulating several other inflammatory mediators like tumor necrosis factors (TNFalpha). The inside of mechanism reveals toxic substance HOCl is produced by MPO is converted to less toxic substances through scavenging action of taurine. Amino acid therapy has its own limitations and to over come such situation there is a need to develop small, simple lipophilic analogs of taurine. Use of taurine analogs has provided better results; for example, N- chloro taurine (NCT) which is a taurine derivative has exhibited therapeutic advances over taurine. Taurine and its analogs with sound experimental and clinical support may constitute a new class of therapeutic agents for SCI., and perhaps this review may provide enough material to think of this.

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“…Studies on painful diabetic neuropathy have shown that taurine is important in the regulation of neuronal Ca 2+ signaling and deficiency of taurine may lead to nerve hyperexcitability and pain [44]. Taurine has also been shown to exhibit naloxone-sensitive antinociceptive effects when tested by hot-plate method in acetic acid and formalin acute pain models [45,46]. Thus the decrease in CSF taurine levels in the labor pain group may emphasize a potential role for this IAA in labor pain mechanism.…”

Section: Inhibitory Amino Acidsmentioning

confidence: 96%

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

et al. 2006

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This study analyzes the relationship between amino acids and pain perception during active labor. Cerebrospinal fluid (CSF) levels of the excitatory amino acids (EAAs)-glutamate, aspartate and their amide forms, inhibitory amino acids (IAAs)-glycine, gamma-amino butyric acid (GABA) and taurine and nitric oxide (NO) related compounds-arginine and citrulline (by-product of NO synthesis) were compared between pregnant women at term pregnancy with labor pain (n = 38) and without labor pain (Caesarian section; n = 30). The levels of aspartate, glycine, GABA and citrulline were significantly higher; whilst taurine was significantly lower in the labor pain group. These findings suggest that aspartate and NO are associated with labor pain. An inhibitory role for the IAA taurine and a pronociceptive role for glycine in labor pain are proposed.

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Antinociceptive effect of taurine and its inhibition by naxolone

Cited by 23 publications

References 16 publications

Activation of Glycine and Extrasynaptic GABA_AReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

Activation of Glycine and Extrasynaptic GABA_AReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

Role of Taurine in Spinal Cord Injury

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

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Antinociceptive effect of taurine and its inhibition by naxolone

Cited by 23 publications

References 16 publications

Activation of Glycine and Extrasynaptic GABAAReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

Activation of Glycine and Extrasynaptic GABAAReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

Role of Taurine in Spinal Cord Injury

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

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Product

Resources

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Activation of Glycine and Extrasynaptic GABA_AReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

Activation of Glycine and Extrasynaptic GABA_AReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis