Antinociceptive Effect of the Essential Oil of <i>Schinus terebinthifolius</i> (female) Leaves on Adult Zebrafish (<i>Danio rerio</i>)

Lima, Maria da Conceição L.; Araújo, José Ismael Feitosa de; Mota, Carolina Gonçalves; Magalhães, Francisco Ernani Alves; Campos, Adriana Rolim; Silva, Priscila T. da; Rodrigues, Tigressa Helena Soares; Matos, Maria Geysillene Castro; Sousa, Karolina Costa de; Sousa, Márcia Barbosa de; Saker-Sampaio, Silvana; Pereira, Anna Luísa; Teixeira, Edson Holanda; Santos, Hélcio Silva dos

doi:10.1089/zeb.2019.1809

Cited by 18 publications

(9 citation statements)

References 31 publications

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“…The use of adult zebrafish as an animal model of nociception has proven to be efficient as a tool for the study of new pharmacological targets [14][15][16][17][18][19] . The decrease in locomotor activity is one of the parameters of nociception in zebrafish 5 and was used here.…”

Section: Discussionmentioning

confidence: 99%

Impact of sex and environmental conditions on the responses to pain in zebrafish

Leite¹,

Santos²,

Ribeiro³

et al. 2021

Brazilian Journal of Pain

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BACKGROUND AND OBJECTIVES: Adult zebrafish (Danio rerio) has been proposed as a low-cost and simple alternative to the use of rodents in laboratory research on novel compounds with antinociceptive potential. This study aimed to assess whether there is an influence of animal sex and the test environment on the orofacial nociceptive behavior of the adult zebrafish. METHODS: First, cinnamaldehyde, menthol, capsaicin, acidic saline, or glutamate was applied into the lips of the adult male or female zebrafish. Naive groups were included as control. The orofacial nociception was quantified in terms of locomotor activity. In other series of experiments, it was evaluated whether the apparatus, acclimatization, period of test, temperature of the water and color of the open field would alter the nociceptive response to cinnamaldehyde. RESULTS: The nociceptive behavior did not depend on the sex of the animal, apparatus, time the test was performed or the color of the open field. However, acclimatization promoted nociceptive behavior in naive animals and did not alter the nociceptive response to cinnamaldehyde (p<0.01 vs acclimatized naive). The nociception behavior was presented only when the test was performed at a temperature of 26ºC (p<0.01 vs naive). CONCLUSION:The results suggest the need to control the environment and water temperature as an environmental sour- Impact of sex and environmental conditions on the responses to pain in zebrafishImpacto do sexo e das condições ambientais nas respostas do peixe-zebra à dor

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Section: Discussionmentioning

confidence: 99%

Impact of sex and environmental conditions on the responses to pain in zebrafish

Leite¹,

Santos²,

Ribeiro³

et al. 2021

Brazilian Journal of Pain

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“…During embryonic development, zebrafish will create melanin in their bodies; zebrafish exposed to EOs show a large decrease in this melanin, which might be indicative of an anti-melanogenic effect (Ho et al, 2023;Kim et al, 2023;Yan et al, 2023;Zhou et al, 2020). In addition, the anti-nociceptive effects of EOs on a zebrafish model of chemically induced pain were investigated (Batista et al, 2021;Lima et al, 2020). Moreover, the effects of EOs on anti-osteoporotic, anti-genotoxicity, and promotion of intestinal microbial homeostasis have been investigated in zebrafish models (Hasankhani et al, 2023;Khalil et al, 2011;Stephen, 2019).…”

Section: Zebrafish Models For the Evaluation Of Other Bioactivitiesmentioning

confidence: 99%

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Wang,

Yu,

Ding

et al. 2023

Qual. Assur. Saf. Crops Foods

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Essential oils (EOs) derived from crops, especially aromatic plants, have been well-acknowledged to provide several health benefits for humans. Zebrafish as an unprecedented tool has been widely used as an excellent vertebrate model in labs owing to its many useful characteristics. Its applications for rapidly and economically screening and identifying toxicity, safety, and bioactivity of EOs may serve to meet the rising demand for nutraceuticals, food supplements, and natural cosmetics. In this study, we summarized the research progress of zebrafish models in evaluating EOs. In addition, toxicity, safety, and various bioactivities of EOs were summarized using a wide variety of readily applicable zebrafish models covering antioxidant, anti-inflammatory, angiogenesis inhibition, neuromodulation, anesthesia, anti-melanogenesis, analgesic activities, etc. In conclusion, zebrafish is a valuable animal model for evaluating the bioactivity and safety of EOs, and using such a model may contribute to speeding up the identification of novel EOs with potential health functions and quality assessment, which in turn boosts the recognition of aromatic plants as important industrial crops and encourages a healthier way of life.

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“…In mammals, it exerts antifungal, healing, and anti-allergic effects [ 66 - 68 ], as well as anti-nociception in rats with chronic sciatic nerve injury-based model of neuropathic pain [ 69 ]. Paralleling its effects in rodents, the essential oil from leaves of this herb also evokes behavioral antinociceptive effects in the zebrafish formalin, cinnamaldehyde, capsaicin, glutamate, acidic and hypertonic saline models of pain [ 70 ].…”

Section: Effects Of American Traditional Medicine In Zebrafish Modelsmentioning

confidence: 99%

Exploring CNS Effects of American Traditional Medicines using Zebrafish Models

Abreu

Costa

Giacomini

et al. 2022

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: Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.

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Antinociceptive Effect of the Essential Oil of Schinus terebinthifolius (female) Leaves on Adult Zebrafish (Danio rerio)

Cited by 18 publications

References 31 publications

Impact of sex and environmental conditions on the responses to pain in zebrafish

Impact of sex and environmental conditions on the responses to pain in zebrafish

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Exploring CNS Effects of American Traditional Medicines using Zebrafish Models

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