Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents

Abstract

The results confirm the popular use of Zanthoxylum rhoifolium as an analgesic, and contribute to the pharmacological knowledge of this species because it was shown that EtOH and its less polar partition fractions (HEX, AcOEt) have an antinociceptive effect in models of chemical nociception, and that lupeol appears to be one of the constituents responsible for this effect.

Zanthoxylum Genus as Potential Source of Bioactive Compounds

“…The study carried out with Z. chilipirone shows that with doses of 100 and 200 mg/kg of each extract is possible to detect significantly inhibition in the paw lick, results that suggest that the extracts from Z. chiloperone possess constituents with antinociceptive activity (Villalba et al, 2007). Moreover, the study with extracts of Z. rhoifolium sought to confirm its popular use, and shows for the first time that ethanol extract of Z. rhoifolium stem bark, its fractions and one of the major constituents (lupeol) have antinociceptive activity when administered orally in different models of chemical nociception in mice (Pereira et al, 2010).…”

“…Z. tingoassuiba has been marketed since 1923 by Flora Medicinal J. Monteiro da Silva Laboratory, as part of herbal medicinal product called Uva do Mato®, which is prescribed for muscle cramps and spasms (Da Silva et al, 2008). Z. rhoifolium also has been commercialized in Brazil as a component of herbal tea mixtures sold in drugstores, supermarkets and popular markets (Pereira et al, 2010;Da Silva et al, 2007a). …”

Lemon Pepper Fruit Extract (<i>Zanthoxylum acanthopodium</i> DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages <i>In Vitro</i>

“…3c) as compared to LPS treatment alone. anti-vascular inflammatory, antiproliferative, antinociceptive and anticaries potentials (Guo et al, 2010;Li et al, 2010;Pereira et al, 2010;Chou et al, 2011;Rodriguez-Guzman et al, 2011). Unfortunately, the scientific evidence of LPFE (Z. acanthopodium DC.)…”

Aqueous Extracts of Dried Fruits of &lt;i&gt;Zanthoxylum armatum&lt;/i&gt; DC., (Rutaceae) Induce Cellular and Nuclear Damage Coupled with Inhibition of Mitotic Activity &lt;i&gt;in Vivo&lt;/i&gt;

“…Many species have been used in different parts of the world especially in Asia, Africa and America to treat a number of diseases in humans and animals [8][9][10][11]. Extracts of Z. nitidum exhibit antibacterial activity in vitro, as well as antioxidative properties [12,13].…”