Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats

Liu, Yue; Ni, Yuan; Zhang, Wei; Sun, Yue; Ma, Zhengliang; Gu, Xiaoping

doi:10.1038/s41598-017-01909-8

Cited by 21 publications

(16 citation statements)

References 48 publications

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“…In another rat study using the paw incision model, caloric restriction further reduced the magnitude of mechanical hypersensitivity compared to normal low-fat chow feeding (Liu et al, 2017), complementing the findings of the high-fat diet studies.…”

mentioning

confidence: 64%

High-fat diet and post-operative pain: Why the hospital cafeteria may matter

Strong

2018

Brain, Behavior, and Immunity

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mentioning

confidence: 64%

High-fat diet and post-operative pain: Why the hospital cafeteria may matter

Strong

2018

Brain, Behavior, and Immunity

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“…Additionally, with LitLab™, we found strong associations between the genes that comprised our organ network and pain signaling and physiological response to pain. In line with this, fasting and calorie restriction have an analgesic effect in murine models [ [77] , [78] , [79] ], and intermittent fasting was proposed as a non-invasive, inexpensive, and implementable strategy to chronic pain treatment (reviewed in [ 80 ]). Key underlying mechanisms in fasting-enhanced neuroplasticity include a short-term corticosterone increase, a reduction in GABAergic inhibition, and an increase in protein chaperons and neurotrophic growth factors such as brain-derived neurotrophic factor (BDNF), which exerts positive effects on neuronal survival and synaptogenesis [ [81] , [82] , [83] ].…”

Section: Discussionmentioning

confidence: 99%

Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting

Huang

Makhlouf

AbouMoussa

et al. 2020

Molecular Metabolism

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Objective Fasting regimens can promote health, mitigate chronic immunological disorders, and improve age-related pathophysiological parameters in animals and humans. Several ongoing clinical trials are using fasting as a potential therapy for various conditions. Fasting alters metabolism by acting as a reset for energy homeostasis, but the molecular mechanisms underlying the beneficial effects of short-term fasting (STF) are not well understood, particularly at the systems or multiorgan level. Methods We performed RNA-sequencing in nine organs from mice fed ad libitum (0 h) or subjected to fasting five times (2–22 h). We applied a combination of multivariate analysis, differential expression analysis, gene ontology, and network analysis for an in-depth understanding of the multiorgan transcriptome. We used literature mining solutions, LitLab™ and Gene Retriever™, to identify the biological and biochemical terms significantly associated with our experimental gene set, which provided additional support and meaning to the experimentally derived gene and inferred protein data. Results We cataloged the transcriptional dynamics within and between organs during STF and discovered differential temporal effects of STF among organs. Using gene ontology enrichment analysis, we identified an organ network sharing 37 common biological pathways perturbed by STF. This network incorporates the brain, liver, interscapular brown adipose tissue, and posterior-subcutaneous white adipose tissue; hence, we named it the brain-liver-fats organ network. Using Reactome pathways analysis, we identified the immune system, dominated by T cell regulation processes, as a central and prominent target of systemic modulations during STF in this organ network. The changes we identified in specific immune components point to the priming of adaptive immunity and parallel the fine-tuning of innate immune signaling. Conclusions Our study provides a comprehensive multiorgan transcriptomic profiling of mice subjected to multiple periods of STF and provides new insights into the molecular modulators involved in the systemic immunotranscriptomic changes that occur during short-term energy loss.

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“…To date, there are few reports regarding pathological pain hypersensitivity relevant to oral mucosal injury, although previous studies have shown that post-traumatic pain hypersensitivity was induced in a traumatic injury model (Kumar, Sarumathi, Veerabahu, & Raman, 2013;Liu et al, 2017;Mamet et al, 2017). Clinically, it has long been known that the oral mucosa is unique in its mechanical and thermal sensitivity compared with that of the skin, suggesting that the mechanical and thermal sensory mechanisms in the oral mucosa are different from those of the body's surface (Green & Gelhard, 1987;Komiyama & De Laat, 2005).…”

Section: Discussionmentioning

confidence: 99%