Antinociceptive effects of galanin in the nucleus accumbens of rats

Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain

“…Previous studies reported that galanin and its receptors might be involved in the transmission and modulation of nociceptive information in the central nervous system (Yu et al, 2001;Liu and Hökfelt, 2002;Hua et al, 2004;Wiesenfeld-Hallin et al, 2005;Xu et al, 2008;Jin et al, 2010). Our previous study showed that intra-nucleus accumbens (NAc) injection of galanin increased the hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulation in intact rats, indicating that galanin might play an antinociceptive role in the NAc (Xu et al, 2012a).…”

“…Although a multitude of studies have proved that the NAc is an important limbic structure of the brain with roles in pain modulation Jin et al, 2010;Li et al, 2010;Xu et al, 2012a), the underlying antinociceptive mechanism of galanin and especially galanin receptors in NAc remain largely unclear. Therefore, the present study investigated whether galanin and its receptors were involved in the modulation of nociceptive information in the NAc of rats with inflammatory pain.…”

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

“…Similarly, administration of high doses of galanin into the ARC decreases nociception by a PKC-and opioiddependent mechanism, probably by influencing the PAG Sun et al, 2003Sun et al, , 2007Sun and Yu, 2005). Administration of galanin into the central nucleus of the amygdala (possibly by a GAL 1 -and opioid-dependent mechanism) (Jin et al, 2010), the tuberomammillary nucleus (Sun et al, 2004), and the nucleus accumbens (Xu et al, 2012a) decreases painrelated behaviors. These effects are inhibited by the putative galanin receptor antagonist galantide, which blocks all galanin receptors.…”

Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathy

“…Many studies have reported that galanin and its receptors are involved in many physiological functions and pathological processions4678. Previous studies have demonstrated that galanin and galanin receptors play important roles in the transmission and/or modulation of nociception of the central nervous system, at spinal cord levels79, as well as in the brain, such as hypothalamic arcuate nucleus, nucleus accumbens, periaqueductal grey, and the central nucleus of amygdala10111213141516171819. Wang and her colleagues demonstrated that administration of galanin into periaqueductal grey induced significant antinociceptive effects in intact rats and rats with mononeuropathy1620.…”