Antinociceptive Effects of Oxymorphone‐Butorphanol‐Acepromazine Combination in Cats

Briggs, Shannon; Sneed, Kristi; Sawyer, Donald C.

doi:10.1111/j.1532-950x.1998.tb00158.x

Cited by 39 publications

(32 citation statements)

References 16 publications

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“…(i) additive analgesia in somatic pain assays and supra-additive analgesia in visceral pain paradigms, along with a reduction in adverse side effects such as respiratory depression, and tolerance, dependence and hyperalgesia from chronic MOR agonist treatment was attenuated by pretreatment with a KOR agonist ([14, 15, 17–19, 50, 53, 55–58], see also [67]);…”

Section: Discussionmentioning

confidence: 99%

“…In a later study, Dr. Briggs et al, as a graduate student, examined the interactions of butorphanol combined with oxymorphone in the cat [14]. The combined drugs exhibited synergistic antinociception in the CRD over the response to each drug administered separately, but without the initial phase of excitement seen with oxymorphone alone.…”

Section: Initial Studies With Mixed Opioid Agonistsmentioning

confidence: 99%

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Effects of Combined Opioids on Pain and Mood in Mammals

Rech

Mokler

Briggs

2012

Pain Research and Treatment

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The authors review the opioid literature for evidence of increased analgesia and reduced adverse side effects by combining mu-opioid-receptor (MOR) agonists, kappa-opioid-receptor (KOR) agonists, and nonselective low-dose-opioid antagonists (LD-Ant). We tested fentanyl (MOR agonist) and spiradoline (KOR agonist), singly and combined, against somatic and visceral pain models. Combined agonists induced additive analgesia in somatic pain and synergistic analgesia in visceral pain. Other investigators report similar effects and reduced tolerance and dependence with combined MOR agonist and KOR agonist. LD-Ant added to either a MOR agonist or KOR agonist markedly enhanced analgesia of either agonist. In accordance with other place-conditioning (PC) studies, our PC investigations showed fentanyl-induced place preference (CPP) and spiradoline-induced place aversion (CPA). We reduced fentanyl CPP with a low dose of spiradoline and reduced spiradoline CPA with a low dose of fentanyl. We propose combined MOR agonist, KOR agonist, and LD-Ant to produce superior analgesia with reduced adverse side effects, particularly for visceral pain.

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Section: Discussionmentioning

confidence: 99%

Section: Initial Studies With Mixed Opioid Agonistsmentioning

confidence: 99%

Effects of Combined Opioids on Pain and Mood in Mammals

Rech

Mokler

Briggs

2012

Pain Research and Treatment

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“…In the Introduction we reviewed our studies of mu-opioid-receptor (MOR) agonist and kappa-opioid-receptor (KOR) agonist antinociceptions (ANC) in the colorectal distension test (CRD), alone or combined, in cats and rats [7,9,10,12,16]. The purpose for that review was to describe incidental observations of drug-induced behavioral effects that were observed during those experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning antinociceptive effects (ANC), both agonists were active when administered singly. With combined agonists, additive ANC was usually observed in somatic pain test models [7,8], whereas synergistic (supra-additive) ANC responses occurred in visceral pain tests on pairing the agonists [9,10,11] (see below for more details).…”

Section: Introductionmentioning

confidence: 99%

Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box

2010

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Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for preference or aversion. Group A always received saline SC before 15-minute sessions. Group B received fentanyl SC (0.003, 0.006, 0.012 mg/kg), Group C received low and medium doses of agonists SC, and Group D received spiradoline (0.3, 0.6, 1.2 mg/kg) SC during Training Sessions 1-4, rats being restricted to the drug-associated compartment. Rats received saline when restricted to the placebo-associate compartment and on test days with access to both shuttle-box compartments. In Phase 2 of the study, Training Session 5, Combinations of mu and kappa agonists were substituted in Groups B, C, and D. Dose-related preference to fentanyl and aversion to spiradoline occurred during Test Sessions 1-4. During Test Session 5, fentanyl preference in Group B was suppressed by spiradoline, rats in Group C had a saline-like response to combined agonists, and spiradoline aversion in Group D was attenuated by fentanyl. These findings suggest that combined doses of mu and kappa agonists, while additive for antinociception, offset the rewarding and punishing effects of each other.

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“…However, pharmacological profiles of butorphanol seem to depend on the species and conditions used in testing. In humans, the use of butorphanol as premedication did not change the interoperative fentanyl requirement for hysterectomy 34 and butorphanol has been reported to have a synergistic effect when used together with m-agonist in cats 35 and rats. 36 Butorphanol was also used in rabbits, 37 rats 38 and humans 39 to reverse the respiratory depression caused by fentanyl without compromising postoperative analgesia.…”

Section: Schö Ffmann Et Al Piglet Responses To Propofol/fentanyl Anamentioning

confidence: 99%

Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl

et al. 2009

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The purpose of the study was to assess the haemodynamic (blood pressure and heart rate) changes and stress responses (serum cortisol and serum amyloid A [SAA] concentrations) to surgery in piglets during total intravenous anaesthesia (TIVA) with propofol and fentanyl. After preanaesthetic medication with intramuscular midazolam (0.5 mg/kg body mass), ketamine (10 mg/kg) and butorphanol (0.5 mg/kg) anaesthesia was induced in five piglets, with intravenous propofol (1 mg/kg) followed by tracheal intubation and mechanical lung ventilation. Soft tissue surgery was performed in the jugular and inguinal regions during TIVA with propofol (8 mg/kg/h) and fentanyl (35 mg/kg/h). Anaesthesia was maintained for 300 min after surgery as the piglets were the control group of a project involving extracorporeal membrane oxygenation. Mean plasma cortisol concentration decreased significantly (P , 0.05) from 59 + 39.9 nmol/L (mean + 1 SD) before surgery to 7.5 + 2.5 nmol/L 300 min after end of surgical procedure. The mean SAA concentrations increased over the same period from 1.6 + 2.3 mg/mL to 4.2 + 5.6 mg/mL without statistical significance. The baseline ( presurgery) mean arterial pressure (MAP) was 72 + 9 mmHg compared with 72 + 11 mmHg 300 min after end of surgery. Neither heart rate nor lactate concentrations changed significantly over the same time points: heart rate was 104 + 11 and 103 + 15 beats/min whereas mean lactate concentrations were reduced from 1.14 + 0.45 mmol/L to 0.90 + 0.22 mmol/L. Haemodynamic stability, a decrease in serum cortisol and a non-statistically significant rise in mean SAA concentrations suggest that the anaesthetic described suppresses the stress response of piglets to surgery without adverse cardiovascular effects. Therefore, it may prove useful in cardiovascular research.

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Antinociceptive Effects of Oxymorphone‐Butorphanol‐Acepromazine Combination in Cats

Cited by 39 publications

References 16 publications

Effects of Combined Opioids on Pain and Mood in Mammals

Effects of Combined Opioids on Pain and Mood in Mammals

Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box

Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl

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