Antinociceptive effects of purified Curcuma longa in mice

Sharma, Ashish; Rauniar, Gajendra Prasad

doi:10.18203/2319-2003.ijbcp20160766

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Studies done by Neha et al [9] and Sharma et al [10] showed similar results. Furthermore, C. longa (400 mg/kg) and ibuprofen (30 mg/kg) almost have comparable anti-nociceptive activity.…”

Section: Phukan and Dassupporting

confidence: 70%

A Comparative Study of Anti-Nociceptive Activity of Curcuma Longa Linn. With That of Ibuprofen in Experimental Animals

Phukan¹,

Das²

2020

Asian J Pharm Clin Res

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Objective: The aim of the study is to evaluate and compare the analgesic activities of Curcuma longa Linn. in the experimental animals. Methods: The present study was conducted in the Department of Pharmacology, Gauhati Medical College and Hospital, after getting approval from the Institutional Animal Ethics Committee (No MC/68F/2009/MAR-19/02). Healthy rodents weighing between 150 and 200 g were selected and randomly divided into five groups, each group consisting of six animals. Tail-flick analgesiometer was used to assess the analgesic activity of C. longa Linn. and ibuprofen in the experimental animals. Appropriate statistical analyses like Student’s t-test were used to analyze the data. Results: The mean reaction time (s) was prolonged on gradually increasing the dose of C. longa Linn. from 200 to 400 mg/kg. At 400 mg/kg dose C. longa Linn. produced similar analgesic activity as compared to ibuprofen (30 mg/kg). Conclusion: From the study, it can be concluded that curcumin has the capacity to attenuate pain, and when administered in high doses, may produce similar activity as other conventional NSAID’s.

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“…Studies done by Neha et al [9] and Sharma et al [10] showed similar results. Furthermore, C. longa (400 mg/kg) and ibuprofen (30 mg/kg) almost have comparable anti-nociceptive activity.…”

Section: Phukan and Dassupporting

confidence: 70%

A Comparative Study of Anti-Nociceptive Activity of Curcuma Longa Linn. With That of Ibuprofen in Experimental Animals

Phukan¹,

Das²

2020

Asian J Pharm Clin Res

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“…An aqueous extract of Curcuma longa produced via soxhlet extraction in distilled water was given orally once daily to adult albino mice for 21 days in a study at the doses of 50, 100 or 200 mg/kg [ 23 ]. The study found that 100 and 200 mg/kg of the extract could delay the onset of pentylenetetrazol-induced seizures, though 50 mg/kg of the extract had no significant effect.…”

Section: Resultsmentioning

confidence: 99%

“…Using the United States Food and Drug Administration human equivalent dose recommendations [ 56 ], an 8.130 mg/kg dose of aqueous Curcuma longa extract delivered as a daily intraperitoneal injection into a 60 kg human for 21 days [ 23 ] could treat tonic-clonic (grand mal) type generalized seizures and a 16.26 mg/kg dose [ 23 ] primary generalized seizures.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Curcuma longa and Its Neuroactive Components for the Management of Epileptic Seizures: A Systematic Review

Choo

Shaikh

2021

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: Curcuma longa (Turmeric) is a tropical herbaceous perennial plant of the family Zingiberaceae and contains curcuminoids, sesquiterpenoids and monoterpenoids as its major components. Given the broad range of activities that Curcuma Longa possesses and also its use as a traditional epilepsy remedy, this review attempts to systematically review the experimentally proven activities of Curcuma longa and its bioactive components, which are related to the management of epileptic seizures. Using the PRISMA model, five databases (Google Scholar, PubMed, ScienceDirect, SCOPUS and SpringerLink) were searched using the keywords [“Curcuma longa” AND “Epilepsy”] and [“Curcuma longa” AND “Seizures”], leaving with 34 articles that met the inclusion criteria. The present systematic review elaborated on the experimentally proven potential of Curcuma longa components, such as an aqueous extract of Curcuma longa itself, Curcuma longa oil and active constituents like curcuminoids and bisabolene sesquiterpenoids found in Curcuma longa with anti-seizure potential. Using human equivalent dose calculations, human treatment parameters were suggested for each component by analysing various studies in this review. This review also determined that the principal components possibly exert their anti-seizure effect via the reduction of corticosterone, modulation of neurotransmitters signalling, modulation of sodium ion channels, reduction of oxidative DNA damage, reduction of lipid peroxidation, upgregulation of brain-derived neurotrophic factor (BDNF) and γ-aminobutyric acid (GABA) mediated inhibition. It is anticipated that this review will help pave the way for future research into the development of Curcuma longa and its neuroactive constituents as potential drug candidates for the management of epilepsy.

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Antinociceptive effects of purified Curcuma longa in mice

Cited by 2 publications

References 13 publications

A Comparative Study of Anti-Nociceptive Activity of Curcuma Longa Linn. With That of Ibuprofen in Experimental Animals

A Comparative Study of Anti-Nociceptive Activity of Curcuma Longa Linn. With That of Ibuprofen in Experimental Animals

Mechanism of Curcuma longa and Its Neuroactive Components for the Management of Epileptic Seizures: A Systematic Review

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