Antinociceptive profile of the methanolic extract of Neorautanenia mitis root in rats and mice

Vongtau, H. O.; Abbah, J.; Mosugu, O.; Chindo, Ben A.; Ngazal, I.E.; Salawu, Adeola Oluwakanyinsola; Kwanashie, Helen O.; Gamaniel, K.

doi:10.1016/j.jep.2004.03.014

Cited by 56 publications

(29 citation statements)

References 17 publications

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“…The hot-plate and tail flick tests were useful in elucidating centrally mediated anti-nociceptive responses, which focuses mainly on changes above the spinal cord level 15,16 . The hot-plate method and tail flick test are considered to be selective to examine compounds acting through opioid receptor.…”

Section: Discussionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory and Anti-Ulcer Activity of Ethanol and Ethyl Acetate Extracts of Tecomaria Capensis Leaves

Jothi¹,

Devi²,

Krishna³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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In the present study ethyl acetate and ethanol extracts of leaves of Tecomaria capensis were screened for analgesic, anti-inflammatory and anti-ulcer activity. The analgesic activity was performed by two thermal models. One is hot plate method and another one is tail flick method. The two extracts of Tecomaria capensis leaves have showed analgesic activity in both methods. The anti-inflammatory activity was investigated by two methods. One is carrageenan induced paw edema method (in-vivo) and other is HRBC stabilization method (in-vitro). In both methods ethyl acetate and ethanol extracts showed anti-inflammatory activity. Anti-ulcer activity was done by aspirin induced method. In this, various biochemical parameters like ulcer index, gastric juice, pH, free acidity, total acidity and percentage protection has been investigated. Further, histopathological studies have also been examined. Ethyl acetate and ethanol extracts have showed anti-ulcer activity. In all the activities ethyl acetate showed a comparable activity to that of standard.

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Section: Discussionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory and Anti-Ulcer Activity of Ethanol and Ethyl Acetate Extracts of Tecomaria Capensis Leaves

Jothi¹,

Devi²,

Krishna³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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“…The tuber of Neorautanena mts is widely used as fish poison in most parts of Africa (Vongtau et al, 2000(Vongtau et al, , 2004Joseph et al, 2004). N. mts contains pachyrrhizine, rotenone, 12-hydroxyrotenone, neorotenone, neorautanone, neoduline, nepseudin, 4-methoxyneoduline, rautandiol A and rautandiol B.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants

Malebo¹,

Tanja²,

Cal³

et al. 2010

Tanzania J Hlth Res

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The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Anncka (Enanta) kummerae (Annonaceae), Artemsa annua (Asteraceae), Pseudospondas mcrocarpa (Anacardiaceae), Drypetes natalenss (Euphorbiaceae), Acrdocarpus chloropterus (Malpighiaceae), Maytenus senegalenss (Celastraceae) and Neurautanena mts (Papilonaceae), were evaluated n vtro against Plasmodum falcparum K1, Trypanosoma bruce rhodesense STIB 900 and axenic Leshmana donovan MHOM-ET-67/82. Out of the 25 extracts tested, 17 showed good antiplasmodial activity (IC 50 0.04-5.0 µg/ml), 7 exhibited moderate anti-trypanosomal activity (IC 50 2.3-2.8 µg/ml), while 5 displayed mild anti-leishmanial activity (IC 50 8.8-9.79 µg/ml). A. kummerae, A. annua, P. mcrocarpa, D. natalenss, M. senegalenss and N. mts extracts had good antiplasmodial activity (IC 50 0.04-2.1 µg/ml) and selectivity indices (29.2-2,250 µg/ml). The high antiplasmodial, moderate anti-trypanosomal and mild anti-leishmanial activity make these plants good candidates for bioassay-guided isolation of anti-protozoal compounds which could serve as new lead structures for drug development.

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“…Pain is centrally controlled via a number of complex processes including opiate, dopaminergic, descending noradrenergic and serotonergic systems. [22][23][24][25][26] The analgesic effect produced by the EEMM may be through central mechanisms involving these receptor systems or via peripheral mechanisms involved in the inhibition of PGs, LTs, and other endogenous substances that plays fundamental role in inflammation and pain.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Pyretic and Analgesic Activity of Marsilea Minuta Linn.

Sudan¹,

Velmurugan²,

Gunasekaran³

et al. 2015

Int. Res. J. Pharm.

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Pyrexia and analgesia are associated with several pathological conditions. Synthetic drugs available for the treatment of these conditions cause multiple unwanted effects. The main objective of the present work is to find out the good pharmacological activities in herbal source. The current study was aimed to investigate the antipyretic and analgesic properties of ethanolic leaf extract of Marsilea minuta Linn (EEMM) in rats. EEMM was employed to assess antipyretic activity in Brewer's yeast-induced pyrexia in rats and the analgesic activity was studied using tail-immersion method and Eddy's hot-plate device maintained at 55°C in rats. Dried powder plant materials were subjected to successive solvent extraction taking Petroleum ether, Benzene, Chloroform, Ethanol and triple distilled water. EEMM at a dose of 200 mg/kg and 400 mg/kg p.o were subjected to antipyretic and analgesic activity. The EEMM had significant dose dependent antipyretic and analgesic properties at 200 and 400 mg/kg p.o. The results obtained revealed significant (p < 0.05) antipyretic activity at 400 mg/kg dose tested as compared with standard. Analgesic activity was evaluated using tail-immersion method and Eddy's hot plate method. The analgesic activity was observed maximum at 400 mg/kg (significance p < 0.001). Paracetamol (150 mg/kg p.o) and Diclofenac sodium (9 mg/kg i.p) was taken as standard drug. The results of the present study demonstrate that EEMM possess significant antipyretic and analgesic activity. This study provides evidences for the antipyretic and analgesic activity of Marsilea minuta Linn which could partly contribute to its ethno medical use.

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Antinociceptive profile of the methanolic extract of Neorautanenia mitis root in rats and mice

Cited by 56 publications

References 17 publications

Analgesic, Anti-Inflammatory and Anti-Ulcer Activity of Ethanol and Ethyl Acetate Extracts of Tecomaria Capensis Leaves

Analgesic, Anti-Inflammatory and Anti-Ulcer Activity of Ethanol and Ethyl Acetate Extracts of Tecomaria Capensis Leaves

Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants

Evaluation of Anti-Pyretic and Analgesic Activity of Marsilea Minuta Linn.

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