Antinociceptive properties of dalargin used in anesthesiologic protection

Shloznikov, B. M.; Donich, S. G.; Гребенчиков, О. А.; Махмутов, Р. Ф.; Лихванцев, В. В.; Kuznetsov, A. Yu.; Peretrukhin, A I; Fomchenkov, E. P.

doi:10.1007/bf00839657

Cited by 2 publications

(1 citation statement)

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“…Фармакологические эффекты даларгина на µ и δ ОР послужили теоретической основой использования гексапепти да в качестве средства анестезиологической защиты сначала в эксперименте [32], а затем и в клинике [33]. Первоначально, некоторые авторы, в том числе и пишущие эти строки, рассма тривали даларгин, как возможную альтернативу наркотичес ким аналгетикам [34][35][36].…”

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Pharmacological Preconditioning: Role of Opioid Peptides

Лихванцев¹,

Гребенников²,

Шапошников³

et al. 2012

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Pharmacological Preconditioning: Role of Opioid Peptides

Лихванцев¹,

Гребенников²,

Шапошников³

et al. 2012

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Stress protection method for surgical treatment of patients with head and neck cancer

Vasiliev,

Kulbakin,

Choynzonov

et al. 2023

Opuholi golovy i šei

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Introduction. The surgical stage of treatment is the most important component of the combined method of treatment in cancer patients. However, it is associated with the development of a number of complications caused by stress. In this regard, the modern concept of an anesthesiological manual should also be aimed at protecting the body from surgical stress, which requires the search and development of new gentle methods of anesthesia.Aim. To provide an overview of modern stress protection methods in anesthesia and consider the role of dalargin with carbohydrate loading as a component of stress protection in oncological surgery.Materials and methods. Using the electronic resources of the PubMed and eLibrary search engines, a literary review of 147 scientific papers over the past 30 years has been conducted, which contain an evidence-based experimental and clinical base on the use of dalargin in medical practice.Results. A systematic review of stress protection methods in anesthesiology is presented. The role of dalargin in anesthesiological practice during surgical treatment in cancer patients, including when performing delayed reconstructions, is shown.Conclusion. The use of dalargin in combination with carbohydrate loading in cancer patients is justified and requires further detailed study. The ability to stimulate endogenous opioid receptors and modulate pain perception, its organoprotective and anti-inflammatory properties, as well as a favorable safety profile make dalargin a valuable addition to the tools for anesthesia in oncology.

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Antinociceptive properties of dalargin used in anesthesiologic protection

Cited by 2 publications

References 1 publication

Pharmacological Preconditioning: Role of Opioid Peptides

Pharmacological Preconditioning: Role of Opioid Peptides

Stress protection method for surgical treatment of patients with head and neck cancer

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