Antinuclear antibodies: A marker associated with steroid dependence in patients with ulcerative colitis

Barahona-Garrido, Josué; Camacho-Escobedo, Jesús; García-Martínez, Carlos I; Tocay, H.; Cabiedes, Javier; Yamamoto-Furusho, Jesús K.

doi:10.1002/ibd.20852

Cited by 19 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnostic findings are summarized in Table 1 . Taken together, the immunological alterations were compatible with the previously known ulcerative colitis ( 11 ). The electrophysiological findings (Figure 1 ) would be compatible with primary (idiopathic) generalized epilepsy; however, the history for epileptic seizures including absences and myoclonic jerks was negative.…”

Section: Case Presentationsupporting

confidence: 85%

Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam

et al. 2017

View full text Add to dashboard Cite

BackgroundSchizophrenia-like disorders can be divided into endogenic or primary, idiopathic, polygenetic forms, and different secondary, organic subgroups [e.g., (para)epileptic, immunological, degenerative]. Epileptic and paraepileptic explanatory approaches have a long tradition due to the high rate of electroencephalography (EEG) alterations in patients with schizophrenia.Case presentationWe present the case of a 23-year-old female patient suffering, since the age of 14 years, from a fluctuating paranoid-hallucinatory syndrome with formal thought disorder, fear, delusions of persecution, auditory, visual, and tactile hallucinations, as well as negative and cognitive symptoms. Laboratory measurements showed increased titers of antinuclear antibodies (ANAs) in the context of ulcerative colitis. While there was no clear history or evidence of epileptic seizures, the EEG showed generalized 3 Hz polyspike wave complexes. Under treatment with levetiracetam, the symptoms disappeared and the patient was able to complete vocational training.ConclusionThe schizophrenia-like symptoms associated with epileptiform discharges but not overt seizures and the good response to antiepileptic treatment could be interpreted in the context of a (para)epileptic pathomechanism. The EEG alterations might be due to a polygenetic effect due to different genes. Mild immunological mechanisms in the framework of ulcerative colitis and increased ANA titers might have supported the network instability. This case report illustrates (1) the importance of EEG screenings in schizophrenia, (2) a potential pathogenetic role of epileptiform discharges in a subgroup of patients with schizophrenia-like symptoms, and (3) that antiepileptic medication with levetiracetam could be a successful treatment alternative in schizophrenia-like disorders with EEG alterations.

show abstract

Section: Case Presentationsupporting

confidence: 85%

Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam

et al. 2017

View full text Add to dashboard Cite

show abstract

“…One report listed antinuclear antibodies as a possible predictive factor of steroid dependency in patients with UC. 37 This report did not mention a direct association between Mayo score as a measurement tool of disease severity and steroid dependency. In our study, a higher Mayo score was shown to be associated with steroid dependency.…”

Section: Corticosteroid In Ulcerative Colitismentioning

confidence: 89%

Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis

Yoon

Cheon

Park

et al. 2011

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Several studies have identified several indicators that confer a poor prognosis associated with UC. Examples include: the presence of antinuclear antibodies in DM patients 28 which are associated with uveitis, steroid dependency 29 , and paradoxical rheumatological manifestations resulting from treatment involving anti- tumour necrosis factor agents 30 . Additionally, the presence of mucocutaneous manifestations occurring in DM were also associated with primary sclerosing cholangitis in UC patients 31 .…”

Section: Discussionmentioning

confidence: 99%

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Tseng

Chang

Liao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

On a molecular level, two autoimmune diseases: ulcerative colitis (UC) and dermatomyositis share common genetic determinants. On a clinical level, case reports evidenced the co-occurrence of these two diseases. We therefore hypothesize that UC is potentially associated with increased cumulative incidence of dermatomyositis. The goals of this retrospective cohort study were to evaluate whether UC is associated with increased cumulative incidence of dermatomyositis independent of sex and age. For comparison, we also assessed the cumulative incidence of polymyositis in UC and control subjects. The study enrolled 3,133 UC subjects and 14,726 control subjects. The cumulative incidence of dermatomyositis was significantly higher in UC than that of control subjects (p = 0.026), but the cumulative incidence of polymyositis was comparable between UC and control subjects (p = 0.596). UC was independently associated with the increased incident dermatomyositis (hazard ratio: 6.19, 95% confidence interval = 1.77–21.59, p = 0.004) after adjusting for sex, age, and concomitant rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Similar trends of increased dermatomyositis in UC were observed when patients were stratified based on sex and age. In conclusion, our findings suggest that UC is probably associated with increased cumulative incidence of dermatomyositis, independent of sex, age, and concomitant autoimmune diseases.

show abstract

Antinuclear antibodies: A marker associated with steroid dependence in patients with ulcerative colitis

Abstract: ANAs are associated with steroid dependence in UC patients. Further studies are required to determine the role of ANAs as serological markers for prediction of steroid dependence in order to perform early therapeutic interventions with biological agents.

Cited by 19 publications

References 25 publications

Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam

Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam

Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Contact Info

Product

Resources

About