Antinuclear Antibodies With a Nucleolar Pattern Are Associated With a Significant Reduction in the Overall Survival of Patients With Leukemia: A Retrospective Cohort Study

Wang, Rong; Zhao, Huijuan; Liu, Yang; Kang, Bing; Cai, Jin

doi:10.3389/fonc.2021.631038

Cited by 7 publications

(10 citation statements)

References 41 publications

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“…This staining pattern has consistently shown an association with the presence of malignancy and a poor prognosis if malignancy is identified. Moreover, in a recent study published by the University Hospital of Geneva, it was reported that the relative risk of associated malignancy in the context of ANA stained in a nucleolar pattern was 1.5 [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Scleroderma: A Case Report of Systemic Sclerosis in the Setting of Pulmonary Adenocarcinoma

Marsalisi¹,

Agrawal²,

Karan³

et al. 2023

Cureus

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A 42-year-old female with a past medical history significant for scleroderma and extensive tobacco use presented with a dry cough and pleuritic chest pain. Further workup was significant for leukocytosis, macrocytic anemia, left lower lung mass, bilateral supraclavicular, hilar, and mediastinal lymphadenopathy. After a comprehensive rheumatologic workup was completed, the patient was found to have strongly positive antinuclear antibody (ANA) and negative scleroderma-specific antibodies with fluorescent ANA indicating a nucleolar pattern. We present a case of paraneoplastic scleroderma in the setting of lung adenocarcinoma which emphasizes the bidirectional relationship that exists between malignancy and rheumatic diseases.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic Scleroderma: A Case Report of Systemic Sclerosis in the Setting of Pulmonary Adenocarcinoma

Marsalisi¹,

Agrawal²,

Karan³

et al. 2023

Cureus

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“…The unpaired Student's t ‐test or Mann–Whitney U ‐test was used to analyse the differences between two groups (DC/LF and non‐DC/LF) in demographic and clinical features analysis, according to the normality of the distribution for continuous variables. The chi‐square test was used for categorical variables 26 …”

Section: Methodsmentioning

confidence: 99%

“…The likelihood ratio test was used to evaluate the interaction across subgroups. The abovementioned statistical methods were similar to those used in our previous report 26 …”

Section: Methodsmentioning

confidence: 99%

Viral hepatitis is associated with increased risk of decompensated cirrhosis or liver failure in patients positive for liver cytosol antibody type 1

et al. 2023

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Liver cytosol antibody type 1 (anti‐LC1) is reported to be a marker of type 2 autoimmune hepatitis (AIH), a type of autoimmune liver disease (AILD). However, anti‐LC1 is not entirely disease‐specific, and its clinical value in other hepatic diseases has not been well elucidated. Our study aimed to explore the associations between the diagnoses and outcome of decompensated cirrhosis or liver failure (DC/LF) in patients positive for anti‐LC1. A total of 157 patients positive for anti‐LC1 were included in our final analysis. DC/LF was defined as the outcome of patients positive for anti‐LC1. The risk of DC/LF according to diagnosis was estimated using multivariable Cox proportional hazards models, while stratified Cox regression models were used in the subgroup analyses. The diagnoses of patients positive for anti‐LC1 were found to be comprised of various liver disorders. Versus other diagnoses, viral hepatitis was associated with a 2.25‐fold increased risk of DC/LF in these patients, independent of sex, age, disease course, treatment and drinking history. Additionally, the associations were more significant by subgroup analysis in male patients, younger patients, non‐newly diagnosed patients, patients without treatment and patients without drinking history. Anti‐LC1 is not a disease‐specific antibody, as it was found in multiple types of hepatic disease. Furthermore, viral hepatitis rather than AILD was associated with an increased risk of DC/LF in patients positive for anti‐LC1. These findings emphasize the important role of viral hepatitis in the progression of DC/LF in patients positive for anti‐LC1.

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“…Antinuclear antibodies (ANAs) are autoantibodies that react with various nuclear and cytoplasmic components in human cells and are considered as serological markers of autoimmune diseases (AIDs). 1,2 As more and more disease-specific autoantibodies against certain AIDs are identified and studied, ANAs detection has become an important screening method for the diagnosis of various systemic autoimmune rheumatic diseases (SARDs). 3,4 The indirect immunofluorescence assay (IIFA) is recommended as the gold-standard method for ANA detection by the American College of Rheumatology, 5 and it is also recommended by the European Association for the Promotion of Autoimmune Standardization as a reference method for ANA detection.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical characteristics of the dense fine speckled pattern: Indirect immunofluorescence‐antinuclear antibody screening in the Chinese population

et al. 2022

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To investigate the prevalence and clinical significance of the dense fine speckled (DFS) pattern in a large‐scale cohort of Chinese patients. Data on the antinuclear antibody (ANA) and extractable nuclear antigen (ENA) autoantibody obtained from 165 498 patients who attended Peking Union Medical College Hospital from January 2019 to December 2021 were retrospectively analysed. The prevalence of the DFS pattern was 1.14%, and it mainly appeared in young patients (≤24 years old). A higher positive rate of the DFS pattern was observed in patients with dermatosis (18.12%) and systemic autoimmune rheumatic diseases (SARDs) (13.53%). The DFS pattern titre was mostly low or medium (≤1:160). A higher titre was associated with an increased risk of SARDs (p < .001), dermatosis (p = .015) and pulmonary disease (p = .016). In 37 patients with ENA autoantibody positivity, anti‐SSA antibody was the most common (2.55%). If the low titre (<1:160) or the DFS pattern with negative ENA autoantibody were to be used as exclusion criteria for SARDs, the diagnosis would have been missed in 42 or 77 patients, respectively. The prevalence of the DFS pattern was low in ANA test samples and was more common in patients with dermatosis and SARDs, but the titre was usually higher in patients with SARDs. There was no evidence that the DFS pattern could be used as an exclusion criterion for SARDs diagnosis. The DFS pattern was associated with certain pathological states, which may inform the clinical significance of the DFS pattern.

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Antinuclear Antibodies With a Nucleolar Pattern Are Associated With a Significant Reduction in the Overall Survival of Patients With Leukemia: A Retrospective Cohort Study

Cited by 7 publications

References 41 publications

Paraneoplastic Scleroderma: A Case Report of Systemic Sclerosis in the Setting of Pulmonary Adenocarcinoma

Paraneoplastic Scleroderma: A Case Report of Systemic Sclerosis in the Setting of Pulmonary Adenocarcinoma

Viral hepatitis is associated with increased risk of decompensated cirrhosis or liver failure in patients positive for liver cytosol antibody type 1

Prevalence and clinical characteristics of the dense fine speckled pattern: Indirect immunofluorescence‐antinuclear antibody screening in the Chinese population

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